Results 1 to 10 of about 4,508,859 (303)
eLife, 2022 The rapid development of new imaging approaches is generating larger and more complex datasets, revealing the time evolution of individual cells and biomolecules. Single-molecule techniques, in particular, provide access to rare intermediates in complex,
Nadia M Huisjes +7 more
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Nature Communications, 2022 TRIM E3 ligases are key regulators of numerous cellular functions, yet their mechanism of action remains poorly understood. Here, the authors show that paralogous TRIM2 and TRIM3 adopt different self-association and activity profiles but interact in ...
Diego Esposito +3 more
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Benchmarking tomographic acquisition schemes for high-resolution structural biology
Nature Communications, 2020 Here the authors systematically benchmark cryo-electron tomography acquisition schemes to optimize the attainable resolution for subtomogram averaging, and find that dose-symmetric acquisition with even angular sampling provides a better outcome than ...
Beata Turoňová +7 more
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Biotechnology & Biotechnological Equipment, 2021 In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova +4 more
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Structure of the human marker of self 5-transmembrane receptor CD47
Nature Communications, 2021 CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti +15 more
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The simulation of molecular clouds formation in the Milky Way [PDF]
, 2012 Using 3D hydrodynamic calculations we simulate formation of molecular clouds in the Galaxy. The simulations take into account molecular hydrogen chemical kinetics, cooling and heating processes.
A. M. Sobolev +88 more
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Molecular ferroelectric contributions to anomalous hysteresis in hybrid perovskite solar cells [PDF]
, 2014 We report a model describing the molecular orientation disorder in CH3NH3PbI3, solving a classical Hamiltonian parametrised with electronic structure calculations, with the nature of the motions informed by ab-initio molecular dynamics.
Anderson P. W. +4 more
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Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes
Nature Communications, 2022 Thermogenic adipocytes maintain body temperature in response to cold, but how this is tuned during cold and re-warming is unclear. Here, the authors show HIF2α inhibits beige adipocyte retention, regulating PKA catalysis to control dynamic adipocyte ...
Ji Seul Han +14 more
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Ultrafast Molecular Imaging by Laser Induced Electron Diffraction [PDF]
, 2011 We address the feasibility of imaging geometric and orbital structure of a polyatomic molecule on an attosecond time-scale using the laser induced electron diffraction (LIED) technique.
A. Keller +7 more
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Fine- and hyperfine-structure effects in molecular photoionization: II. Resonance-enhanced multiphoton ionization and hyperfine-selective generation of molecular cations [PDF]
, 2016 Resonance-enhanced multiphoton ionization (REMPI) is a widely used technique for studying molecular photoionization and producing molecular cations for spectroscopy and dynamics studies. Here, we present a model for describing hyperfine-structure effects
Germann, Matthias, Willitsch, Stefan
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