Results 11 to 20 of about 4,508,859 (303)
Structure of human TRPM8 channel
Communications Biology, 2023 TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. It is a therapeutic target for anticancer drug development,
Sergii Palchevskyi +7 more
doaj +1 more source
Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
Nature Communications, 2020 Single molecule force measurements have shed light on dynamic biological events, but rare events escape notice owing to low throughput of the methods. Here, the authors combine an array of magnetic tweezers with lateral flow to increase throughput 100 ...
Rohit Agarwal, Karl E. Duderstadt
doaj +1 more source
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4‐2 using proteome arrays
Molecular Systems Biology, 2009 Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain.
Avinash Persaud +8 more
doaj +1 more source
Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling
Scientific Reports, 2022 Multidomain proteins composed of individual domains connected by flexible linkers pose a challenge for structural studies due to their intrinsic conformational dynamics.
Marius Kausas +3 more
doaj +1 more source
Encapsulation kinetics and dynamics of carbon monoxide in clathrate hydrate. [PDF]
, 2014 Carbon monoxide clathrate hydrate is a potentially important constituent in the solar system. In contrast to the well-established relation between the size of gaseous molecule and hydrate structure, previous work showed that carbon monoxide molecules ...
Du, Shiyu +12 more
core +4 more sources
Molecular Metabolism, 2014 Background/objectives: Fasting dyslipidemia is commonly observed in insulin resistant states and mechanistically linked to hepatic overproduction of very low density lipoprotein (VLDL).
Jennifer Taher +9 more
doaj +1 more source
Metabolic reconstruction identifies strain‐specific regulation of virulence in Toxoplasma gondii
Molecular Systems Biology, 2013 Increasingly, metabolic potential is proving to be a critical determinant governing a pathogen's virulence as well as its capacity to expand its host range. To understand the potential contribution of metabolism to strain‐specific infectivity differences,
Carl Song +6 more
doaj +1 more source
Jahn-Teller distortion in Cs4C60 studied by vibrational spectroscopy [PDF]
, 2002 We have measured the infrared spectra of Cs(4)C(60) in the temperature range 220 - 450 K. Two anomalies in the low-frequency modes at 270 K and 400 K point to changes in molecular or crystal structure.
Borondics, Ferenc +4 more
core +1 more source
Interplay of buried histidine protonation and protein stability in prion misfolding
Scientific Reports, 2017 Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear.
Anatoly Malevanets +10 more
doaj +1 more source
The infra-red spectrum and molecular structure of HNCS [PDF]
, 1950 From an examination of the microwave spectra of four isotopic species of isothiocyanic acid, Beard and Dailey (1) recently obtained the following values for the molecular parameters in the ground vibrational ...
Badger, Richard M., Jones, L. H.
core +1 more source