Results 11 to 20 of about 11,784,011 (316)

Mars, a molecule archive suite for reproducible analysis and reporting of single-molecule properties from bioimages

eLife, 2022
The rapid development of new imaging approaches is generating larger and more complex datasets, revealing the time evolution of individual cells and biomolecules. Single-molecule techniques, in particular, provide access to rare intermediates in complex,
Nadia M Huisjes, Thomas M Retzer, Matthias J Scherr, Rohit Agarwal, Lional Rajappa, Barbara Safaric, Anita Minnen, Karl E Duderstadt   +7 more
doaj   +1 more source

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity

Nature Communications, 2022
TRIM E3 ligases are key regulators of numerous cellular functions, yet their mechanism of action remains poorly understood. Here, the authors show that paralogous TRIM2 and TRIM3 adopt different self-association and activity profiles but interact in ...
Diego Esposito, Jane Dudley-Fraser, Acely Garza-Garcia, Katrin Rittinger   +3 more
doaj   +1 more source

Synthesis and molecular modeling of metap2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-naproxen as possible breast cancer agents

, 2022
New thiosemicarbazides (3, 5-6), 1,2,4-triazoles (14-15) and thioethers (22-68) from derived (S)-Naproxen were synthesized in this study. The structure of these compounds were elucidated by spectral (FT-IR, 1H NMR, 13C NMR) methods, besides elemental ...
A. I., Uba, Küçükgüzel, Güniz, S.K., Sevinç, O., Orun, Yılmaz, Ö., Yelekçi, K., S., Tiryaki, Telçi, D., P. M., Timer, O., Çuhadar   +9 more
core   +1 more source

Benchmarking tomographic acquisition schemes for high-resolution structural biology

Nature Communications, 2020
Here the authors systematically benchmark cryo-electron tomography acquisition schemes to optimize the attainable resolution for subtomogram averaging, and find that dose-symmetric acquisition with even angular sampling provides a better outcome than ...
Beata Turoňová, Wim J. H. Hagen, Martin Obr, Shyamal Mosalaganti, J. Wouter Beugelink, Christian E. Zimmerli, Hans-Georg Kräusslich, Martin Beck   +7 more
doaj   +1 more source

Influence of the haloaryl moiety over the molecular packing in N-phenacylbenzimidazoles crystallizing in the same space group

, 2021
In this study, a family of N -phenacylbenzimidazoles 1–3 synthesized in high yields (90–93%) by the N - phenacylation reaction of NH -benzimidazole ( 4 ) under ultrasonic conditions was recrystallized from the mixture EtOH:AcOEt (1:1 V/V).
Vargas Oviedo, Diana, Macías, Mario A., Portilla, Jaime   +2 more
core   +1 more source

The antitumor activity of cannabidiol on lung cancer cell lines A549 and H1299: the role of apoptosis

Biotechnology & Biotechnological Equipment, 2021
In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova, Lazar I. Lazarov, Maria Petrova, Alexander Tzintzarov, Iva Ugrinova   +4 more
doaj   +1 more source

Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition [PDF]

, 2019
A series of symmetrical imidazolinium chloride salts bearing secondary N-alkyl substituents were synthesized in good yield by the reaction of N,N'-dialkylethane-1,2-diamines and HC(OEt)(3) in the presence of NH4Cl.
Karaman, Muhammet, Kaya, Ruya, Özdemir, İsmail, Taslimi, Parham, Gülçin, İlhami, Isik, Yilmaz, Işık, Yılmaz, Yiğit, Beyhan, Yiğit, Murat   +8 more
core   +1 more source

Structure of the human marker of self 5-transmembrane receptor CD47

Nature Communications, 2021
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan   +15 more
doaj   +1 more source

Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes

Nature Communications, 2022
Thermogenic adipocytes maintain body temperature in response to cold, but how this is tuned during cold and re-warming is unclear. Here, the authors show HIF2α inhibits beige adipocyte retention, regulating PKA catalysis to control dynamic adipocyte ...
Ji Seul Han, Yong Geun Jeon, Minsik Oh, Gung Lee, Hahn Nahmgoong, Sang Mun Han, Jeehye Choi, Ye Young Kim, Kyung Cheul Shin, Jiwon Kim, Kyuri Jo, Sung Sik Choe, Eun Jung Park, Sun Kim, Jae Bum Kim   +14 more
doaj   +1 more source

Molecular Structure of Galactokinase [PDF]

Journal of Biological Chemistry, 2003
Galactokinase plays a key role in normal galactose metabolism by catalyzing the ATP-dependent phosphorylation of alpha-D-galactose to galactose 1-phosphate. In humans, mutations in the galactokinase gene can lead to the diseased state referred to as Type II galactosemia. Here we describe the three-dimensional structure of galactokinase from Lactococcus
James B, Thoden, Hazel M, Holden
openaire   +2 more sources