Results 41 to 50 of about 12,307,698 (317)

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase

Nature Communications, 2017
The WD40 domain of the SCFCdc4ubiquitin ligase targets substrates via multiple phosphorylated degron motifs. The authors define a second degron-binding WD40 pocket that imparts a negative allosteric effect on binding to the primary pocket, and thereby ...
Veronika Csizmok, Stephen Orlicky, Jing Cheng, Jianhui Song, Alaji Bah, Neda Delgoshaie, Hong Lin, Tanja Mittag, Frank Sicheri, Hue Sun Chan, Mike Tyers, Julie D. Forman-Kay   +11 more
doaj   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Structure-Property Relationship Of 3-(N-Phthalimidomethyl)-4-Amino-1,2,4-Triazole-5-Thione: A Structural, Spectroscopic And Dft Study

, 2017
The title molecule, 3-(N-phthalimidomethyl)-4-amino-1,2,4-triazole-5-thione (C11H9N5O2S), was synthesized by the fusion of N-Phthaloylglycine and thiocarbohydrazide at 145 degrees C.
Avcı, Davut, Atalay, Yusuf, Rumana Quershi, Azra Yaqub, Tamer, Ömer, Moazzam H. Bhatti, Uzma Yunus, Muhammad Nadeem, Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Fizik Bölümü   +8 more
core   +1 more source

Ternary layered double hydroxide and its calcined product for Indigo Carmine removal: experimental investigation, DFT, and modelling

Scientific Reports
In response to the challenge of dye pollution in wastewater, a remediation approach was established based on the synthesis of ZnCdAl-layered double hydroxides (ZnCdAl-LDH) through a coprecipitation method.
Fatima Boucif, Nouria Mahrez, Gania Bessaha, Fatiha Bessaha, Amine Amar, Amine Khelifa, Stefano Bellucci   +6 more
doaj   +1 more source

FAN1 Activity on Asymmetric Repair Intermediates Is Mediated by an Atypical Monomeric Virus-type Replication-Repair Nuclease Domain

Cell Reports, 2014
FAN1 is a structure-selective DNA repair nuclease with 5′ flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair nuclease (“VRR-Nuc”) “module” that commonly
Simon Pennell, Anne-Cécile Déclais, Jiejin Li, Lesley F. Haire, Wioletta Berg, José W. Saldanha, Ian A. Taylor, John Rouse, David M.J. Lilley, Stephen J. Smerdon   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement

, 2008
SummaryWe report the solution NMR structure of a designed dimetal-binding protein, di-Zn(II) DFsc, along with a secondary refinement step employing molecular dynamics techniques.
Matteo Dal Peraro, Dal Peraro, M., Weixia Liu, Wand, A. J., Valentine, K. G., Liu, W., DeGrado, W. F., Katrin Spiegel, William F. DeGrado, Calhoun, J. R., Klein, M. L., Kathleen G. Valentine, Michael L. Klein, Spiegel, K., Jennifer R. Calhoun, A. Joshua Wand   +15 more
core   +1 more source

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications
TRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain.
Jane Dudley-Fraser, Diego Esposito, Katherine A. McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger   +5 more
doaj   +1 more source