Results 61 to 70 of about 11,784,011 (316)

On the irregularity of some molecular structures [PDF]

Canadian Journal of Chemistry, 2017
Measures of the irregularity of chemical graphs could be helpful for QSAR/QSPR studies and for the descriptive purposes of biological and chemical properties such as melting and boiling points, toxicity, and resistance. Here, we consider the following four established irregularity measures: the irregularity index by Albertson, the total irregularity ...
Abdo, Hosam, Dimitrov, Darko, Gao, Wei
openaire   +2 more sources

Molecular footprints of the Holocene retreat of dwarf birch in Britain [PDF]

, 2014
© 2014 The Authors. Molecular Ecology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original ...
Bodles, WJA, Borrell, JS, Kuttapitiya, A, Richard A. Nichols, Wang, N, Nian Wang, William J A. Bodles, Anasuya Kuttapitiya, Richard J A. Buggs, Buggs, RJA, James S. Borrell, Nichols, RA   +11 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone

, 2023
New Schiff bases bearing 5-nitroisatin-thiocarbohydrazone (1-9) have been prepared. The chemical structures of these compounds have been clarified by spectroscopic methods (IR, 1H NMR, and 13C NMR), and elemental analysis.
Yakan H., Omer H.H.S., Buruk O., Çakmak Ş., Marah S., Veyisoğlu A., Muğlu H., Ozen T., Kütük H., Yakan, H, Omer, HHS, Buruk, O, Cakmak, S, Marah, S, Veyisoglu, A, Muglu, H, Ozen, T, Kutuk, H   +1 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structure and mechanism of the HECT ligase HECTD3

Nature Communications
HECT E3 ligases regulate many cellular processes, yet how they recognise their substrates and synthesise specific types of poly-ubiquitin chains is still incompletely understood.
Jessica Huber, Diego Esposito, Sarah Maslen, Dominic O. Chambers, J. Mark Skehel, Katrin Rittinger   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Molecular Structures of Polyglutamates

Kobunshi Kagaku, 1963
いままであまり取り上げられなかった合成ポリペプチドのポリグルタミン酸メチルの高重合体を合成し, 固体薄膜の赤外線吸収スペクトルを岩塩および臭化カリウム領城について測定した。特にα-Helix構造に基く特性吸収帯を調べるため, L型およびD型アミノ酸の各種共重合体を合成し, 吸収スペクトルを比較した。Helix構造に特有であると思われる1120, 800, 720, 620, 563cm-1の各吸収帯を見出し, これらの帰属について調べた。このうちで特に620cm-1の吸収帯はNH面外変角振動に基くアミドV吸収帯と確認され, ポリペプチド分子の空間構造の研究に有用であることがわかった。
openaire   +6 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

Nature Communications, 2018
NS1 of influenza A virus inhibits TRIM25 activity, which is an E3 ligase important for induction of the interferon response. Here, Koliopoulos et al. present structures of TRIM25 and NS1 and show how NS1 binding interferes with substrate recognition of ...
Marios G. Koliopoulos, Mathilde Lethier, Annemarthe G. van der Veen, Kevin Haubrich, Janosch Hennig, Eva Kowalinski, Rebecca V. Stevens, Stephen R. Martin, Caetano Reis e Sousa, Stephen Cusack, Katrin Rittinger   +10 more
doaj   +1 more source