Results 61 to 70 of about 4,508,859 (303)

Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA

Nature Communications
Nucleotide excision repair is a DNA repair pathway which detects and fixes various DNA lesions that distort the structure of DNA. In bacteria, the pathway starts with the UvrA protein which has two adenosine triphosphatase modules and forms dimers.
Shivlee Nirwal, Mariusz Czarnocki-Cieciura, Weronika Zajko, Krzysztof Skowronek, Roman H. Szczepanowski, Marcin Nowotny   +5 more
doaj   +1 more source

Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit

Nature Communications, 2023
Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu, Philipp F. Popp, Mònica Santiveri, Aritz Roa-Eguiara, Yumeng Yan, Freddie J. O. Martin, Zheyi Liu, Navish Wadhwa, Yong Wang, Marc Erhardt, Nicholas M. I. Taylor   +10 more
doaj   +1 more source

Competitive Solvation of the Imidazolium Cation by Water and Methanol

, 2014
Imidazolium-based ionic liquids are widely used in conjunction with molecular liquids for various applications. Solvation, miscibility and similar properties are of fundamental importance for successful implementation of theoretical schemes.
Chaban, Vitaly
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Direct imaging of the induced‐fit effect in molecular self‐assembly [PDF]

, 2019
Molecular recognition is a crucial driving force for molecular self‐assembly. In many cases molecules arrange in the lowest energy configuration following a lock‐and‐key principle.
Baum, Sebastian, Corso, Martina, Franke, Katharina J., Lotze, Christian, Pascual, José I., Yang, Zechao   +5 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Observation of a shape resonance of the positronium negative ion

Nature Communications, 2016
The Positronium negative ion is formed by two electrons bound to a positron, and experimental investigations of its states and energy levels are difficult due to its short lifetime.
Koji Michishio, Tsuneto Kanai, Susumu Kuma, Toshiyuki Azuma, Ken Wada, Izumi Mochizuki, Toshio Hyodo, Akira Yagishita, Yasuyuki Nagashima   +8 more
doaj   +1 more source

The local structure of molecular reaction intermediates at surfaces [PDF]

, 2008
A critical review is presented of the results of (experimental) quantitative structural studies of molecular reaction intermediates at surfaces; i.e. molecular species that do not exist naturally in the gas phase and, in most cases, are implicated in ...
(erratum), Afsin, Afsin, Bader, Bader, Bao, Bao, Baumgärtel, Bengió, Benner, Besenthal, Bittencourt, Bjrkqvist, Blackman, Bondino, Bondino, Booth, Booth, Booth, Brown, Burch, Caldwell, Caldwell, Carley, Chambers, Chen, Churchill, Colaianni, Corrigan, Crapper, D. P. Woodruff, Daum, Demuth, Dietrich, Franco, Franco, Guo, Guo, Gutiérrez-Sosa, Haase, Harrison, Harrison, Hayden, Heinz, Hirschmugl, Hofmann, Holub-Krappe, Huerta, Jackson, Jackson, Jakob, Johnston, Johnston, Kang, Kerkar, Kesmodel, Kittel, Knight, Koestner, Kordesch, Kordesch, Kröger, Kunimatsu, Käckell, Lehwald, Lindner, Madix, Miners, Mullins, Nakahashi, Ormerod, Outka, Outka, Pascal, Puschmann, Robinson, Sapína, Sayago, Sayago, Schaff, Schindler, Schindler, Schreiber, Sotiropoulos, Starke, Stöhr, Stöhr, Takayanagi, Thevuthasan, Uekusa, Ulman, Wander, Wander, Weiss, Wienberg, Woodruff, Woodruff, Woodruff, Woodruff, Woodruff, Yamanaka, Yawney, Zheng, Öström   +103 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

Nature Communications, 2019
Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination which are removed by nucleases such as RuvC. Here the authors provide structural and biochemical details on the steps required for the completion of
Karolina Maria Górecka, Miroslav Krepl, Aleksandra Szlachcic, Jarosław Poznański, Jiří Šponer, Marcin Nowotny   +5 more
doaj   +1 more source