Results 81 to 90 of about 11,784,011 (316)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Differentiation between enamines and tautomerizable imines in the oxidation reaction with TEMPO

Nature Communications, 2018
Tautomerization of imines into enamines is the basis of their similar reactivity; however, minor structural changes may lead to different outcomes. Here, the authors show that the reaction of cyclohexanone and amines in presence of TEMPO affords either α-
Xiaoming Jie, Yaping Shang, Zhe-Ning Chen, Xiaofeng Zhang, Wei Zhuang, Weiping Su   +5 more
doaj   +1 more source

Preoperative assessment of cardiovascular risk in patients undergoing noncardiac surgery: the Orion study

Monaldi Archives for Chest Disease, 2020
In patients undergoing noncardiac surgery risk indices can estimate patients’ perioperative risk of major cardiovascular complications. The indexes currently in use were derived from observational studies that are now outdated with respect to the current
Giampaolo Scorcu, Annarita Pilleri, Paolo Contu, Pompilio Faggiano, Roberto Floris, Alessandra Mereu, Luisella Pistis, Roberto Sessego, Luigi Valentino, Claudia Sardu   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Synthesis, characterization, crystal and molecular structure and theoretical study of N-(naphthalen-1-yl)-2-(piperidin-1-yl) acetamide, a selective butyrylcholinesterase inhibitor

, 2022
In this study, we reported for the first time the crystalline and molecular structure of the compound N-(naphthalen-1-yl) -2- (piperidin-1-yl) acetamide.
Polo-Cuadrado, Efraín, González, Wendy, Brito, Iván, Gutiérrez, Margarita, Prent-Peñaloza, Luis, Cisterna, Jonathan, Osorio, Edison, Camargo-Ayala, Lorena   +7 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The University of Chicago Department of Physics Laboratory of Molecular Structure and Spectra Technical Report, 1955

, 1955
Report containing articles, manuscripts, and tabulations of recorded spectra created by the Spectroscopic Laboratory of the University of ...
University of Chicago. Laboratory of Molecular Structure and Spectra.
core  

Semiempirical molecular dynamics studies of C60/C70 fullerence oxides : C60O, C60O2 and C70O

, 2009
The spectral analysis indicates that all isomers of C60O, C70O and C60O2 have an epoxide-like structure (an oxygen atom bridging across a C–C bond). According to the geometrical structure analysis, there are two isomers of fullerene monoxide C60O (the 5 ...
Chen, Likely; Lee, Kuei-jen; 王伯昌; Wang, Bo-cheng
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions

Scientific Reports
Phosphorylation plays a crucial role in the regulation of many fundamental cellular processes. Phosphorylation levels are increased in many cancer cells where they may promote changes in mitochondrial homeostasis.
Nina Kunová, Gabriela Ondrovičová, Jacob A. Bauer, Veronika Krajčovičová, Matyáš Pinkas, Barbora Stojkovičová, Henrieta Havalová, Veronika Lukáčová, Lenka Kohútová, Július Košťan, Lucia Martináková, Peter Baráth, Jiří Nováček, Sebastian Zoll, Sami Kereïche, Eva Kutejová, Vladimír Pevala   +16 more
doaj   +1 more source