Results 71 to 80 of about 4,508,859 (303)

Preoperative assessment of cardiovascular risk in patients undergoing noncardiac surgery: the Orion study

Monaldi Archives for Chest Disease, 2020
In patients undergoing noncardiac surgery risk indices can estimate patients’ perioperative risk of major cardiovascular complications. The indexes currently in use were derived from observational studies that are now outdated with respect to the current
Giampaolo Scorcu, Annarita Pilleri, Paolo Contu, Pompilio Faggiano, Roberto Floris, Alessandra Mereu, Luisella Pistis, Roberto Sessego, Luigi Valentino, Claudia Sardu   +9 more
doaj   +1 more source

High carrier mobility and strong fluorescence emission: Toward highly sensitive single‐crystal organic phototransistors

Aggregate, 2023
Organic single crystals (OSCs) offer a unique combination of both individual and collective properties of the employed molecules, but it remains highly challenging to achieve OSCs with both high mobilities and strong fluorescence emissions for their ...
Jingwei Tao, Zhaoyang Liu, Dan Liu, Huanli Dong, Jiangbo Jing, Jiaxing Song, Leijing Liu, Bin Xu, Wenjing Tian   +8 more
doaj   +1 more source

The Equilibrium Structure of Prolate Magnetized Molecular Cores

, 2009
The structure of molecular cloud cores supported by thermal pressure and a poloidal magnetic field is reinvestigated in the magnetohydrostatic and axisymmetric approximation.
Basu, Bonnor, Ciolek, Curry, Ebert, Evans, Fiege, Gammie, Jijina, Jones, Li, Nakano, Offner, Ryden, Schnee, Shu, Stutz, Tassis, Troland   +18 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Differentiation between enamines and tautomerizable imines in the oxidation reaction with TEMPO

Nature Communications, 2018
Tautomerization of imines into enamines is the basis of their similar reactivity; however, minor structural changes may lead to different outcomes. Here, the authors show that the reaction of cyclohexanone and amines in presence of TEMPO affords either α-
Xiaoming Jie, Yaping Shang, Zhe-Ning Chen, Xiaofeng Zhang, Wei Zhuang, Weiping Su   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions

Scientific Reports
Phosphorylation plays a crucial role in the regulation of many fundamental cellular processes. Phosphorylation levels are increased in many cancer cells where they may promote changes in mitochondrial homeostasis.
Nina Kunová, Gabriela Ondrovičová, Jacob A. Bauer, Veronika Krajčovičová, Matyáš Pinkas, Barbora Stojkovičová, Henrieta Havalová, Veronika Lukáčová, Lenka Kohútová, Július Košťan, Lucia Martináková, Peter Baráth, Jiří Nováček, Sebastian Zoll, Sami Kereïche, Eva Kutejová, Vladimír Pevala   +16 more
doaj   +1 more source

Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

eLife, 2020
Abundant APOBEC3 (A3) deaminase-mediated mutations can dominate the mutational landscape (‘mutator phenotype’) of some cancers, however, the basis of this sporadic vulnerability is unknown.
Birong Shen, Joseph H Chapman, Michael F Custance, Gianna M Tricola, Charles E Jones, Anthony V Furano   +5 more
doaj   +1 more source

Inter-molecular structure factors of macromolecules in solution: integral equation results

, 1999
The inter-molecular structure of semidilute polymer solutions is studied theoretically. The low density limit of a generalized Ornstein-Zernicke integral equation approach to polymeric liquids is considered.
A. Johner, A. P. Chatterjee, C. F. Schmidt, D. Chandler, D. Chandler, G. Jannink, G. T. Pickett, H. Benoit, H. P. Deutsch, I. Carmesin, J. D. Cloizeaux, J. P. Hansen, K. S. Schweizer, K. S. Schweizer, K. S. Schweizer, K. S. Schweizer, K. S. Schweizer, L. Onsager, M. Daoud, M. Fuchs, M. Fuchs, M. Fuchs, M. Müller, P. G. de Gennes, P. J. Flory, R. J. Baxter, R. Ullman, S. Müller, T. Shimada, V. Yamakov   +29 more
core   +1 more source