Results 51 to 60 of about 4,508,859 (303)
Structure and mechanism of the HECT ligase HECTD3
Nature CommunicationsHECT E3 ligases regulate many cellular processes, yet how they recognise their substrates and synthesise specific types of poly-ubiquitin chains is still incompletely understood.
Jessica Huber +5 more
doaj +1 more source
Frontiers in Immunology, 2022 The emergence of SARS-CoV-2 variants that escape from immune neutralization are challenging vaccines and antibodies developed to stop the COVID-19 pandemic.
José M. Casasnovas +13 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
, 2010 We aim to study the properties of the dense molecular gas towards the inner few 100 pc of four nearby starburst galaxies dominated both by photo dissociation regions (M82) and large-scale shocks (NGC253, IC342 and Maffei2), and to relate the chemical and
Aladro, Rebeca +4 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition
Nature Communications, 2018 NS1 of influenza A virus inhibits TRIM25 activity, which is an E3 ligase important for induction of the interferon response. Here, Koliopoulos et al. present structures of TRIM25 and NS1 and show how NS1 binding interferes with substrate recognition of ...
Marios G. Koliopoulos +10 more
doaj +1 more source
Molecular and electronic structure investigation of encapsulated polytiophenes [PDF]
, 2017 Insulated molecular wires (IMWs) are expected to be applied to various optoelectronic applications due to their unique photophysical, electronic, and mechanical properties which originate from the absence of -stacking.[1] Kazunori et al have succeeded in
Brambilla, Luigi +9 more
core
Tight binding description of the electronic response of a molecular device to an applied voltage
, 2011 We analyze the effect of an external electric field on the electronic structure of molecules which have been recently studied as molecular wires or diodes.
Allan, Guy +2 more
core +2 more sources
Can Sgr A* flares reveal the molecular gas density PDF? [PDF]
, 2017 Illumination of dense gas in the Central Molecular Zone (CMZ) by powerful X-ray flares from Sgr A* leads to prominent structures in the reflected emission that can be observed long after the end of the flare. By studying this emission we learn about past
Churazov, E. +3 more
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source