Results 31 to 40 of about 12,307,698 (317)

GLP-1 receptor agonism ameliorates hepatic VLDL overproduction and de novo lipogenesis in insulin resistance

Molecular Metabolism, 2014
Background/objectives: Fasting dyslipidemia is commonly observed in insulin resistant states and mechanistically linked to hepatic overproduction of very low density lipoprotein (VLDL).
Jennifer Taher, Christopher L. Baker, Carmelle Cuizon, Hassan Masoudpour, Rianna Zhang, Sarah Farr, Mark Naples, Celine Bourdon, Zdenka Pausova, Khosrow Adeli   +9 more
doaj   +1 more source

Metabolic reconstruction identifies strain‐specific regulation of virulence in Toxoplasma gondii

Molecular Systems Biology, 2013
Increasingly, metabolic potential is proving to be a critical determinant governing a pathogen's virulence as well as its capacity to expand its host range. To understand the potential contribution of metabolism to strain‐specific infectivity differences,
Carl Song, Melissa A Chiasson, Nirvana Nursimulu, Stacy S Hung, James Wasmuth, Michael E Grigg, John Parkinson   +6 more
doaj   +1 more source

Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling

Scientific Reports, 2022
Multidomain proteins composed of individual domains connected by flexible linkers pose a challenge for structural studies due to their intrinsic conformational dynamics.
Marius Kausas, Diego Esposito, Katrin Rittinger, Franca Fraternali   +3 more
doaj   +1 more source

Interplay of buried histidine protonation and protein stability in prion misfolding

Scientific Reports, 2017
Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear.
Anatoly Malevanets, P. Andrew Chong, D. Flemming Hansen, Paul Rizk, Yulong Sun, Hong Lin, Ranjith Muhandiram, Avi Chakrabartty, Lewis E. Kay, Julie D. Forman-Kay, Shoshana J. Wodak   +10 more
doaj   +1 more source

The Description of Molecular Structure [PDF]

Proceedings of the National Academy of Sciences, 1975
With the kind permission of the chair, I dedicate this lecture to the memory of my father, Leland W. Parr, who died in December of 1973. For many years Dr. Parr was Professor of Bacteriology and Public Health at George Washington University Medical School, here in Washington.
openaire   +2 more sources

Potassium trihydrogen dioxalate dihydrate (KTO) nonlinear optical (NLO) single crystal for optical limiting application

Results in Physics, 2023
In nonlinear optics, optical power limiting (OPL) compounds are known to be an important class of materials because it has the ability to protect the optical sensor components as well as human eyes from the abrupt intense laser power. Here, we have grown
Ramki Chakaravarthy, Jiang Tao, Chang Liu, Yu Liu, Wei Ren, R Ezhil Vizhi   +5 more
doaj   +1 more source

Acid Red 114 Removal Using a Low-Cost Material: Experimental Study and Statistical Physics Modeling [PDF]

Iranian Journal of Chemistry & Chemical Engineering
An eco-friendly and cost-effective biosorbent has been developed for the efficient elimination of acid red 114 dye from aqueous media. Batch studies were carried out to determine the effects of various operating parameters, namely the effect of ...
Fatiha Bessaha, Gania Bessaha, Fatima Boucif, Samira Ziane, Nouria Mahrez, Ali Çoruh, Amine Khelifa   +6 more
doaj   +1 more source

Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control

Nature Communications, 2021
In Saccharomyces cerevisiae, unchecked proliferation of Ty1 retrotransposons is controlled by the process of copy number control (CNC), which requires the p22/p18 protein, translated from an internal transcript within the Ty1 GAG gene.
Matthew A. Cottee, Sean L. Beckwith, Suzanne C. Letham, Sarah J. Kim, George R. Young, Jonathan P. Stoye, David J. Garfinkel, Ian A. Taylor   +7 more
doaj   +1 more source

NLRP10 engages oxidized DNA through a Schiff-base mechanism and dissociates from NLRP3 upon inflammasome activation

Communications Biology
Mitochondrial DNA release into the cytosol is a critical event in innate immune activation, often acting as a damage-associated molecular pattern (DAMP) that triggers inflammasome assembly.
Julia Elise Cabral, Angela Lackner, Wenjin Jiang, Sophia Lin, Haitian Zhou, Anna Wu, Courtney Demos, Minh Anh Pham, Reginald McNulty   +8 more
doaj   +1 more source

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling

Journal of Lipid Research, 2009
Glucosamine impairs hepatic apolipoprotein B100 (apoB100) production by inducing endoplasmic reticulum (ER) stress and enhancing cotranslational and posttranslational apoB100 degradation (Qiu, W., R. K. Avramoglu, A. C. Rutledge, J. Tsai, and K.
Wei Qiu, Qiaozhu Su, Angela C. Rutledge, Jing Zhang, Khosrow Adeli   +4 more
doaj   +1 more source