Results 31 to 40 of about 2,182,736 (268)

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications
TRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain.
Jane Dudley-Fraser, Diego Esposito, Katherine A. McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger   +5 more
doaj   +1 more source

Engineering a Pseudo-26-kDa Schistosoma Glutathione Transferase from bovis/haematobium for Structure, Kinetics, and Ligandin Studies

Biomolecules, 2021
Glutathione transferases (GSTs) are the main detoxification enzymes in schistosomes. These parasitic enzymes tend to be upregulated during drug treatment, with Schistosoma haematobium being one of the species that mainly affect humans. There is a lack of
Neo Padi, Blessing Oluebube Akumadu, Olga Faerch, Chinyere Aloke, Vanessa Meyer, Ikechukwu Achilonu   +5 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

On the irregularity of some molecular structures [PDF]

Canadian Journal of Chemistry, 2017
Measures of the irregularity of chemical graphs could be helpful for QSAR/QSPR studies and for the descriptive purposes of biological and chemical properties such as melting and boiling points, toxicity, and resistance. Here, we consider the following four established irregularity measures: the irregularity index by Albertson, the total irregularity ...
Abdo, Hosam, Dimitrov, Darko, Gao, Wei
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A machine learning model for site-specific classification of N-glycoprotein fucosylation using tandem mass spectrometry and deep neural network

Journal of Analytical Science and Technology
Protein fucosylation is a biologically significant post-translational modification that modulates protein stability, receptor signaling, and immune function.
Mina Park, Catia Mota, Heeyoun Hwang
doaj   +1 more source

A new cellular model to follow Friedreich's ataxia development in a time-resolved way

Disease Models & Mechanisms, 2015
Friedreich's ataxia (FRDA) is a recessive autosomal ataxia caused by reduced levels of frataxin (FXN), an essential mitochondrial protein that is highly conserved from bacteria to primates.
Tommaso Vannocci, Nathalie Faggianelli, Silvia Zaccagnino, Ilaria della Rosa, Salvatore Adinolfi, Annalisa Pastore   +5 more
doaj   +1 more source

Molecular Structures of Polyglutamates

Kobunshi Kagaku, 1963
いままであまり取り上げられなかった合成ポリペプチドのポリグルタミン酸メチルの高重合体を合成し, 固体薄膜の赤外線吸収スペクトルを岩塩および臭化カリウム領城について測定した。特にα-Helix構造に基く特性吸収帯を調べるため, L型およびD型アミノ酸の各種共重合体を合成し, 吸収スペクトルを比較した。Helix構造に特有であると思われる1120, 800, 720, 620, 563cm-1の各吸収帯を見出し, これらの帰属について調べた。このうちで特に620cm-1の吸収帯はNH面外変角振動に基くアミドV吸収帯と確認され, ポリペプチド分子の空間構造の研究に有用であることがわかった。
openaire   +6 more sources