Results 21 to 30 of about 11,784,011 (316)
Structure of human TRPM8 channel
Communications Biology, 2023 TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. It is a therapeutic target for anticancer drug development,
Sergii Palchevskyi +7 more
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Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4‐2 using proteome arrays
Molecular Systems Biology, 2009 Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain.
Avinash Persaud +8 more
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Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
Nature Communications, 2020 Single molecule force measurements have shed light on dynamic biological events, but rare events escape notice owing to low throughput of the methods. Here, the authors combine an array of magnetic tweezers with lateral flow to increase throughput 100 ...
Rohit Agarwal, Karl E. Duderstadt
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, 2023 © 2022 Elsevier B.V.Despite the great breakthroughs in the field of epilepsy studies, the present drugs are ineffective in one-third of the patients, as well as without providing a definite treatment. There is accumulating evidence suggesting the role of
Akkaya, Birnur +2 more
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Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling
Scientific Reports, 2022 Multidomain proteins composed of individual domains connected by flexible linkers pose a challenge for structural studies due to their intrinsic conformational dynamics.
Marius Kausas +3 more
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Molecular Structure, Spectroscopy and Photochemistry of Alprazolam
, 2022 In this article, a comprehensive study of the molecular structure, spectroscopy, and photochemistry of alprazolam (Xanax (R); 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine) is reported.
ILDIZ, GÜLCE ÖĞRÜÇ +6 more
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Metabolic reconstruction identifies strain‐specific regulation of virulence in Toxoplasma gondii
Molecular Systems Biology, 2013 Increasingly, metabolic potential is proving to be a critical determinant governing a pathogen's virulence as well as its capacity to expand its host range. To understand the potential contribution of metabolism to strain‐specific infectivity differences,
Carl Song +6 more
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Molecular Metabolism, 2014 Background/objectives: Fasting dyslipidemia is commonly observed in insulin resistant states and mechanistically linked to hepatic overproduction of very low density lipoprotein (VLDL).
Jennifer Taher +9 more
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Interplay of buried histidine protonation and protein stability in prion misfolding
Scientific Reports, 2017 Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear.
Anatoly Malevanets +10 more
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The Description of Molecular Structure [PDF]
Proceedings of the National Academy of Sciences, 1975 With the kind permission of the chair, I dedicate this lecture to the memory of my father, Leland W. Parr, who died in December of 1973. For many years Dr. Parr was Professor of Bacteriology and Public Health at George Washington University Medical School, here in Washington.
openaire +2 more sources