Results 51 to 60 of about 370,384 (214)

Antileishmanial and Antitoxoplasmal Activities of 1,4-dihydropyridines

ACS Omega
Abstract: We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reac-tion and evaluated their in vitro activities against Toxoplasma gondii and Leishmania major.
Thaís Oliveira, Yan Robles, Ibrahim Al Nasr, Waleed Koko, Tariq Khan, Ismail Daoud, Seyfeddine Rahali, Noureddine Amdouni, Ridha Ben Said, Antônio Crotti   +9 more
openaire   +3 more sources

Recent Advances in Site‐ and Stereocontrolled Selective Light‐Mediated Functionalizations of Monosaccharide Derivatives

ChemPhotoChem, Volume 10, Issue 10, October 2026.
Once regarded as highly reactive and difficult‐to‐control intermediates, monosaccharide‐derived radicals have emerged as powerful tools for selective synthesis. This review highlights how modern photocatalytic strategies enable the controlled generation of these radicals and their highly regio‐ and stereoselective transformation into structurally ...
Corentin Lefebvre, Norbert Hoffmann
wiley   +1 more source

Synthesis of USP Grade [2,3,7‐13C3]‐Nicotinamide for Human Pharmacokinetic Studies

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 12, October 2026.
We prepared a 17.8‐g quantity of [2,3,7‐13C3]‐nicotinamide in five synthetic steps, with a 42% overall yield, and purified it to > 99% homogeneity, meeting USP standards for oral pharmaceutical dosing. This material is intended for tracking the movement and metabolism of nicotinamide through the human body.
Bruce G. Szczepankiewicz, Karsten J. Koppetsch, Michael P. Drolet, David Cao, Jonathan N. Kremsky, Eric E. Buck, George Rotsides, Greg Griffin, Siead Zegar, Alan Henderson, David J. Livingston   +10 more
wiley   +1 more source

Electrochemical and biological oxidation of 1,4-dihydropyridine derivatives

, 1981
Electrochemical oxidation of 1,4-dihydropyridines I-XII and electrochemical reduction of the nitro group of 4-(2-nitrophenyl)-1,4-dihydropyridines III, VI, IX and XII was studied using cyclic voltametry.
Jiří Ludvík, Miroslav Marek, Antonín Kurfürst, Pavel Rauch   +3 more
core   +1 more source

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1,4-DIHYDROPYRIDINE DERIVATIVE [PDF]

, 2017
A series of substituted 1,4-dihydopyridine derivatives (SC1-SC10) was synthesized via condensation of acetoacetanilide /4-chloro acetoacetanilide and substituted benzaldehyde in methanol with excess amount of ammonia.
Soni, Love Kumar, Chourey, Shikha, Narsinghani, Tamanna   +2 more
core   +1 more source

Smart cellulose‐based room temperature phosphorescent materials: From mechanisms to construction strategies and applications

Smart Molecules, Volume 4, Issue 3, September 2026.
This review elucidates the photophysical mechanisms of cellulose‐based room temperature phosphorescent materials and systematically outlines their construction strategies, such as cluster emission center engineering. This article demonstrates their applications in fields like information encryption and bioimaging, and looks ahead to the core challenges
Shasha Wu, Yifan Zhou, Wanjin Wu, Yan Tang, Mengfan Jing, Jianyu Zhang, Haoke Zhang, Zheng Zhao, Junwei Wang, Laurent Maron, Lijie Liu   +10 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Synthesis new fluorinated 4-phenyl-1,4-dihydropyridine derivatives, as perspective antiarrhythmic and antihypertensive drugs

Results in Chemistry, 2023
Derivatives of dihydropyridines are promising agents for research, as they have high biological activity. Their low toxicity and polytargeted properties make it possible to create new derivatives and identify new biological activity. As part of this work,
Arkadiy Bryzgalov, Tatiana Tolstikova, Borislav Koshcheev, Alexander Maksimov   +3 more
doaj   +1 more source

Synthesis and structural conformation studies of a potent unsymmetrical 1,4-dihydropyridine

, 2008
2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was characterized spectroscopically and confirmed by X-ray diffraction studies.
Naveen, S., Arun Mishra, Shashidhara Prasad, J., Dinesh Manvar, Anandalwar, S. M., Anamik Shah   +5 more
core   +1 more source

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

The Chemical Record, Volume 26, Issue 8, August 2026.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros, Livia C. L. Valente, Thiago Barcellos, Daniela Hartwig, Laura Abenante, Eder J. Lenardão   +5 more
wiley   +1 more source