Results 31 to 40 of about 8,139 (202)

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study [PDF]

, 2017
Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C-4 ...
Edraki, N., Firuzi, O., Khoshneviszadeh, M., Miri, R., Ranjbar, S., Saso, L., Shahraki, O., Zargari, F.   +7 more
core   +1 more source

MODULATION OF CALCIUM CHANNELS IN ARTERIAL SMOOTH-MUSCLE CELLS BY DIHYDROPYRIDINE ENANTIOMERS [PDF]

, 1993
The actions of the optical enantiomers of BAY K 8644 and Sandoz 202,791 were studied on barium inward currents recorded using the whole-cell configuration of the patch clamp technique from enzymatically isolated smooth muscle cells from the rabbit ear ...
Bolton, TB, Hering, S, Hughes, AD, Timin, EN   +3 more
core   +1 more source

Synthesis, crystal structure and Hirshfeld surface analysis of diethyl 2,6-dimethyl-4-(thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2019
In the title compound, C17H21NO4S, the 1,4-dihydropyridine ring has an envelope conformation with the Csp3 atom at the flap. The thiophene ring is nearly perpendicular to the best plane through the 1,4-dihydropyridine ring, the dihedral angle being 82.19 
Trung Vu Quoc, Duong Tran Thi Thuy, Thanh Phung Ngoc, Manh Vu Quoc, Hien Nguyen, Linh Duong Khanh, Anh Tu Quang, Luc Van Meervelt   +7 more
doaj   +1 more source

Synthesis and chromatographic-separation of the stereoisomers of furnidipine [PDF]

, 1993
The four stereoisomers of methyl tetrahydrofuran-2-ylmethyl 2,6-dimethyl-4-(o-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxilate (furnidipine), have been synthesized and separated by chiral chromatography using D-phenylglycine as chiral stationary phase.
Alajarín Ferrández, Ramón, Casa-Juana Muñoz, Miguel Fau de, Sanz-Aparicio, Julia, Statkow, Peter R., Sunkel Letelier, Carlos, Vaquero López, Juan José, Álvarez-Builla Gómez, Julio   +6 more
core   +3 more sources

Data for characterisation of nanoformulations formed by cationic 1,4-dihydopyridine and calix[4]arene compositions

Data in Brief, 2022
In this data file the characterisation of nanoformulations obtained from calix[4]arene/1,4-dihydropyridine (1,4-DHP) compositions in the various component ratio in an aqueous medium was performed by dynamic light scattering (DLS) technique.
Martins Rucins, Roman Rodik, Aiva Plotniece, Nadiia Pikun, Mara Plotniece, Arkadij Sobolev, Vitaly Kalchenko, Karlis Pajuste   +7 more
doaj   +1 more source

3-Methyl 5-[(S)-2-methylbutyl] 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate [PDF]

, 2002
The solvatochromic acid-base indicator 1-hexadecyl-4-[(oxocyclohexadienylidene)ethylene]-1,4-dihydropyridine (HOED) was used to determine surface potentials (Y) of micelles formed from methyldiallyl-ndodecylammonium salts containing different counterions
Franssen, M.C.R., Jongejan, H., Kooijman, H., Sobolev, A., Spek, A.L.   +4 more
core   +6 more sources

1,1′-{[3,5-Bis((dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis[4-(anthracen-9-yl)pyridin-1-ium] Dibromide

Molbank, 2022
A synthesis of a cationic moiety and fluorescent moieties containing amphiphilic 1,4-dihydropyridine (1,4-DHP) derivatives was performed starting with the Hantzsch-type cyclization of dodecyl acetoacetate, phenylaldehyde and ammonium acetate. Bromination
Reinis Ozolins, Mara Plotniece, Karlis Pajuste, Reinis Putralis, Nadiia Pikun, Arkadij Sobolev, Aiva Plotniece, Martins Rucins   +7 more
doaj   +1 more source

Synthesis of bioorganometallic nanomolar-potent CB2agonists containing a ferrocene unit [PDF]

, 2016
A small library of ferrocene-containing amides has been synthesized using standard amide coupling chemistry with ferrocenylamine. Ferrocene analogues of known bioactive adamantylamides were shown to be effective cannabinoid receptor (CB1 and CB2 ...
Ahmedi R., Amélie Barczyk, Aurélien Tourteau, Felder C. C., Frédérique Klupsch, Graham J. Tizzard, John Spencer, Lucas Lemaire, Natascha Leleu-Chavain, Portier M., Rhee M. H., Rinaldi-Carmona M., Régis Millet, Simon J. Coles, Supojjanee Sansook, Wei Tuo, Xavier Dezitter, Zanoozi M.   +17 more
core   +3 more sources

Diethyl 4-(1H-indol-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

IUCrData, 2019
In the title compound, C21H24N2O4, the 1,4-dihydropyridine ring adopts a very flattened boat conformation, with the 3-pyridine substituent in an axial orientation.
Ji Hye Lee, Dongsoo Koh
doaj   +1 more source

Fast microwave-assisted oxidation of 1,4-dihydropyridines with FeCl 3.SiO 2 [PDF]

, 2005
Pyridine derivatives are easily obtained in high yields by microwave-promoted rapid oxidation of the corresponding 1,4-dihydropyridines with ferric chloride hexahydrate and silica gel under solvent-free ...
Alaee, E., Halvagar, M.R., Hosseini, A., Khalilzadeh, M.A., Tajbakhsh, M.   +4 more
core   +1 more source