Results 21 to 30 of about 121,691 (212)
Chemoenzymatic Synthesis of Enantiopure 1,4-Dihydropyridine Derivates
ChemInform, 2004 1,4-Dihydropyridines possess a broad range of biological activities, such as the ability to control the influx of calcium into cells, as well as neuroprotective, antineuro-degenerative, cognition and memory enhancing, anti-inflammatory, antiviral and ...
Sobolev, A. +3 more
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Antischistosomal Activity of 1,4-Dihydropyridines
Drugs and Drug CandidatesBackground/Objectives: Recent reports have demonstrated the antiparasitic activity of 1,4-dihydropyridine (1,4-DHPs). This study aimed to assess the in vitro antischistosomal activity of 24 1,4-DHPs against Schistosoma mansoni adult worms.
Thaís A. S. Oliveira +5 more
doaj +2 more sources
1,4-Dihydropyridine activators in the tiamdipine series.
European Journal of Pharmacology, 1990 The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N ...
Triggle DJ +2 more
core +4 more sources
Conformation of 1,4-dihydropyridine — planar or boat-like? [PDF]
FEBS Letters, 1988 The geometry of the 1,4-dihydropyridine molecule was completely optimized employing three different ab initio basis sets (6–31 G*, 4–31 G, STO—3G).
Cimiraglia, R. +5 more
core +3 more sources
Anticancer Activity of 4-Aryl-1,4-Dihydropyridines
Future PharmacologyWe have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human ...
Thaís A. S. Oliveira +5 more
doaj +2 more sources
Cocrystals of diastereoisomers of 1,4-dihydropyridine derivatives
Acta Crystallographica Section C Crystal Structure Communications, 2006 A mixture of the RR/SS and RS/SR diastereoisomeric pairs of methyl 4-(2,4-dichlorophenyl)-2,7-dimethyl-5-oxo- 1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C19H19Cl2NO3, forms cocrystals in which there is one unique molecule in the asymmetric unit, but ...
Gunduz, MİYASE GÖZDE +3 more
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Antibacterial and antileishmanial activity of 1,4-dihydropyridine derivatives
Chemistry & BiodiversityWe have synthesized twenty-three 1,4-dihydropyridine derivatives (1,4-DHPs) by using a microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bacteria and their ...
Thaís, Oliveira +7 more
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Organocatalytic Enantioselective Synthesis of 1,4‐Dihydropyridines [PDF]
Advanced Synthesis & Catalysis, 2017 AbstractThis review aims to bring light upon a very interesting group of compounds, the 1,4‐dihydropyridines (1,4‐DHPs). These structures are well‐known pharmacophores, used for many years to treat cardiovascular diseases because of their activity as calcium channel blockers.
Auria-Luna, Fernando +2 more
openaire +2 more sources
Кубанский научный медицинский вестник, 2023 Background. In the majority of cases, contemporary pharmacological correction mainly focuses on the most effective analgesia. Therefore, the search for and research into new analgesic drugs are a priority in modern pharmacology.Objective — to establish ...
E. Yu. Bibik +5 more
doaj +1 more source
MODULATION OF CALCIUM CHANNELS IN ARTERIAL SMOOTH-MUSCLE CELLS BY DIHYDROPYRIDINE ENANTIOMERS [PDF]
, 1993 The actions of the optical enantiomers of BAY K 8644 and Sandoz 202,791 were studied on barium inward currents recorded using the whole-cell configuration of the patch clamp technique from enzymatically isolated smooth muscle cells from the rabbit ear ...
S Hering +7 more
core +1 more source