Results 21 to 30 of about 4,494 (179)

Organocatalytic Enantioselective Synthesis of 1,4‐Dihydropyridines [PDF]

Advanced Synthesis & Catalysis, 2017
AbstractThis review aims to bring light upon a very interesting group of compounds, the 1,4‐dihydropyridines (1,4‐DHPs). These structures are well‐known pharmacophores, used for many years to treat cardiovascular diseases because of their activity as calcium channel blockers.
Auria-Luna, Fernando, Marqués-López, Eugenia, Herrera, Raquel P.   +2 more
openaire   +2 more sources

Hantzsch Synthesis of 2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-methoxyphenyl)-1,4-dihydropyridine; a Novel Cyclisation Leading to an Unusual Formation of 1-Amino-2-methoxycarbonyl-3,5-bis(o-methoxyphenyl)-4-oxa-cyclohexan-1-ene

Molecules, 2007
Hantzsch condensation of two equivalents of methyl-3-aminocrotonate with (m-and p)-methoxybenzaldehyde afforded the expected products 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(m-methoxyphenyl)-1,4-dihydropyridine and 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(p ...
Vladimir Vinković, Ivica Cepanec, Mladen Litvić, Mirela Filipan-Litvić   +3 more
doaj   +1 more source

1,1′-{[3,5-Bis(dodecyloxycarbonyl)-4-(naphthalen-2-yl)-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis{4-[(E)-2-(naphthalen-2-yl)vinyl]pyridin-1-ium}dibromide

Molbank, 2022
Synthesis of a double-charged cationic amphiphilic 1,4-dihydropyridine derivative with dodecyl ester groups at positions 3 and 5 of the 1,4-DHP ring was performed starting from Hantzsch type cyclization of dodecyl acetoacetate, 2-naphthaldehyde and ...
Martins Rucins, Martins Kaukulis, Aiva Plotniece, Karlis Pajuste, Nadiia Pikun, Arkadij Sobolev   +5 more
doaj   +1 more source

Synthesis and biological evaluation of 1,2,4-triazoles and 1,3,4-oxadiazoles derivatives linked to 1,4-dihydropyridines scaffold

Acta Chimica Slovenica, 2017
A series of diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivative coupled to 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones moieties at C2,C6 positions of 1,4-dihydropyridine ring system was prepared.
Maghsoud Ziaie, Karim Akbaridilmaghani, Amir Tukmechi   +2 more
doaj   +1 more source

Contraction force versus action potential duration of cardiomyocytes: which methodology is more informative for selection of effective 1,4-dihydropyridine compounds in experimental research?

Acta Medica Lituanica, 2015
Background. Identification of activity properties of new synthesized compounds is important to help choose the adequate research methodology. The goal of this experimental research was to determine the relationship between the chemical structure of 25 ...
Vygantas Barsys, Vida Garalienė, Gediminas Urbonas   +2 more
doaj   +1 more source

Synthesis of novel 1,4-Dihydropyridine derivative labeled with Carbon-14 [PDF]

مجله علوم و فنون هسته‌ای, 2019
Synthesis of 14C-labeled organic compounds is being required by the medical, pharmaceutical, agricultural, industrial, and research centers. The Carbon-14 is essential for the tracking and recognizing the mechanism and performance of the synthesized ...
M.A Ahmadi Faghih, M.H Mosslemin, G Shirvani, M Javaheri   +3 more
doaj   +1 more source

Dimethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2010
In the title compound, C19H23NO6, the 1,4-dihydropyridine ring is twisted slightly from planarity, with a maximum deviation of 0.101 (1) Å, and adopts a very flattened boat conformation.
Tara Shahani, Hoong-Kun Fun, B. Palakshi Reddy, V. Vijayakumar, S. Sarveswari   +4 more
doaj   +1 more source

Dimethyl 2,6-dimethyl-4-(3-phenyl-1H-pyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2012
In the title compound, C20H21N3O4, the 1,4-dihydropyridine ring adopts a boat conformation. An intramolecular C—H...O hydrogen bond generates an S(6) ring motif. The pyrazole ring makes dihedral angles of 87.81 (7) and 45.09 
Hoong-Kun Fun, Suhana Arshad, Shridhar Malladi, Kammasandra Nanjunda Shivananda, Arun M. Isloor   +4 more
doaj   +1 more source

Anticancer Activity of 4-Aryl-1,4-Dihydropyridines

Future Pharmacology
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human ...
Thaís A. S. Oliveira, Jackson B. A. Silva, Tábata R. Esperandim, Nathália O. Acésio, Denise C. Tavares, Antônio E. M. Crotti   +5 more
doaj   +1 more source

Sodium N-(3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carbonyl)-l-methioninate

Molbank, 2020
The development of the methods for amide bond formation is important for various uses in the laboratory and industrial applications. The compounds combined in their structures 1,4-dihydroisonicotinic acids and amino acids linked with an amide bond can be
Egils Bisenieks, Janis Poikans, Aiva Plotniece, Eiva Bernotiene, Wei-Bor Tsai, Arkadij Sobolev   +5 more
doaj   +1 more source