Results 21 to 30 of about 8,139 (202)

Synthesis and Characterisation of 1,1′-{[3,5-Bis(dodecyloxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) Dibromide

Molbank, 2021
In the present work, construction of double-charged cationic amphiphilic 1,1′-{[3,5-bis(dodecyl¬oxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) dibromide (7) was performed in four steps.
Martins Rucins, Karlis Pajuste, Aiva Plotniece, Nadiia Pikun, Roman Rodik, Sergiy Vyshnevskiy, Arkadij Sobolev   +6 more
doaj   +1 more source

Organocatalytic Enantioselective Synthesis of 1,4‐Dihydropyridines [PDF]

Advanced Synthesis & Catalysis, 2017
AbstractThis review aims to bring light upon a very interesting group of compounds, the 1,4‐dihydropyridines (1,4‐DHPs). These structures are well‐known pharmacophores, used for many years to treat cardiovascular diseases because of their activity as calcium channel blockers.
Auria-Luna, Fernando, Marqués-López, Eugenia, Herrera, Raquel P.   +2 more
openaire   +3 more sources

Data for the synthesis and characterisation of 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines as important intermediates for synthesis of amphiphilic 1,4-dihydropyridines

Data in Brief, 2020
This data file describes the synthetic protocol for preparation of the original 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines. In total, 6 unpublished compounds were obtained and characterised.
Martins Rucins, Klavs Pajuste, Arkadij Sobolev, Mara Plotniece, Nadiia Pikun, Karlis Pajuste, Aiva Plotniece   +6 more
doaj   +1 more source

Study of novel 1,4-dihydropyridine derivatives as prospective anti-inflammatory remedies: a randomised controlled trial

Кубанский научный медицинский вестник, 2022
Background. Over the past decades, scientific community is motivated on finding new anti-inflammatory agents with a safe and high-effective profile to manage pathology.Objectives. A study of the anti-inflammatory action of novel compounds, 1,4-dihydropyridine
E. Yu. Bibik, D. S. Krivokolysko, G. A. Batishcheva, A. A. Samokish, Yu. S. Venidiktova, A. V. Myazina, A. A. Pankov, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko   +9 more
doaj   +1 more source

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines

Data in Brief, 2020
In this data file the synthetic procedures for preparation of the original 4-pyridinium-1,4-dihydropyridines (4-Py-1,4-DHP) and their parent compounds – dialkyl 2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylates were described. In total, 5
Klavs Pajuste, Martins Rucins, Ilona Domracheva, Arkadij Sobolev, Nadiia Pikun, Mara Plotniece, Gunars Duburs, Karlis Pajuste, Aiva Plotniece   +8 more
doaj   +1 more source

Novel 1,4-Dihydropyridine Derivatives as Potential Agents with Analgesic Activity IN Orofacial Trigeminal Pain Test: Experimental Preclinical Randomized Trial

Кубанский научный медицинский вестник, 2023
Background. In the majority of cases, contemporary pharmacological correction mainly focuses on the most effective analgesia. Therefore, the search for and research into new analgesic drugs are a priority in modern pharmacology.Objective — to establish ...
E. Yu. Bibik, I. S. Oleynik, A. A. Pankov, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko   +5 more
doaj   +1 more source

Dimethyl 4-(4-formylphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2008
The title compound, C18H19NO5, is a product of the Hantzsch reaction of p-phthalaldehyde, methyl acetoacetate, and ammonium acetate. The 1,4-dihydropyridine ring of the molecule adopts a flattened boat conformation.
Fei Teng, Fanpeng Kong, Qingjian Liu
doaj   +1 more source

Photodegradation of nimodipine and felodipine in microheterogeneous systems [PDF]

, 2012
Indexación: Web of Science; ScieloThe photochemical behavior of nimodipine (NIMO) and felodipine (FELO), photolabile drugs widely used as antihypertensive calcium channel blockers, is studied in constrained media.
Brito, Julio, García, Cristóbal, Günther, Germán, Morales, Javier, Núñez-Vergara, Luis J., Pizarro, Nancy, Pozo, Andrés   +6 more
core   +1 more source

Diisopropyl 1-(4-methoxyphenyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2011
In the title compound, C28H32N2O7, the 1,4-dihydropyridine ring adopts a flattened boat conformation. The two benzene rings are approximately perpendicular to the dihydropyridine ring, forming dihedral angles of 84.29 (9) and 82.96 (9)
Kamini Kapoor, Vivek K. Gupta, Rajni Kant, Milind P. Pawar, Hitendra S. Joshi   +4 more
doaj   +1 more source

Development of Self-Assembling bis-1,4-Dihydropyridines: Detailed Studies of Bromination of Four Methyl Groups and Bromine Nucleophilic Substitution

Molecules, 2023
One of the most important steps in the synthesis of 1,4-dihydropyridine (1,4-DHP) amphiphiles is the bromination of methyl groups in positions 2 and 6 of the entire ring.
Martins Kaukulis, Martins Rucins, Davis Lacis, Aiva Plotniece, Arkadij Sobolev   +4 more
doaj   +1 more source