Results 71 to 80 of about 8,139 (202)

Radical Retrosynthesis of Natural Products Enabled by Iron‐Based Reductive Olefin Coupling

Angewandte Chemie Novit, Volume 2, Issue 1, March 2026.
This review highlights iron‐catalyzed reductive olefin coupling (ROC)—a strategy for C─C bond formation driven by metal‐hydride hydrogen atom transfer (MHAT)—as a key tool in natural products synthesis. This review surveys dozens of total syntheses employing ROC‐based strategies, highlighting its power to forge strained rings, quaternary centers, and ...
Griffin L. Barnes, Alex L. Rerick, Phil S. Baran   +2 more
wiley   +1 more source

Preparation of indole alkaloids via 1,4-dihydropyridine stage or cyano-masked iminium intermediates [PDF]

, 2004
Methods to synthesise substituted pyridine derivatives utilising 1,4-dihydropyridines were studied. Addition of nucleophiles to N-alkyl pyridinium salts and application of the products to alkaloid synthesis were investigated.
Putkonen, Tiina
core  

Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes [PDF]

The prototype 1,4-dihydropyridine (1,4-DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of vasodilating action and a short half-life.
Baarnhielm, Beresford, Borchard, Kobayashi, Mahmoudian, Mahmoudian, Mohri, Moldeus, Ramsch, Roden, Scherling, Scherling, Scherling, Stopher, Teramura, Van Zwieten   +15 more
core   +1 more source

Transfer hydrosilylation [PDF]

, 2016
Transfer hydrogenation is without question a common technology in industry and academia. Unlike its countless varieties, conceptually related transfer hydrosilylations had essentially been unreported until the recent development of a radical and an ionic
Oestreich, Martin
core   +1 more source

Who Lives in a Tin Can Under the (Ultrasonic) Sea: Sponges Made From Perfluoropyridine‐Derived Thiol‐Ene Polymerizations

Journal of Polymer Science, Volume 64, Issue 4, Page 833-847, 15 February 2026.
Tandem mechanochemical‐sonochemical for the strategic synthesis for 2,4,6‐trisubstituted derivatives of perfluoropyridine as bio‐based prepolymer materials. ABSTRACT Substitution of perfluoropyridine (PFP) in the 4‐position through an SNAr reaction is facile through mechanochemical methods, with yields in excess of 99% and short reaction times on a ...
Jason Pulfer, Miriam Aldom, Maxime Colpaert, Andrea Kelley, Tim Storr, Chadron M. Friesen   +5 more
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis [PDF]

, 2018
Many infectious diseases disproportionately affect people in the developing world. Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the highest burden of disease in sub-Saharan Africa.
Afeltra, Bicanic, Butts, Byrnes, Catterall, Ceballos, Chatterji, Chong, Chrysant, Clinical and Laboratory Standards Institute (CLSI), Clinical and Laboratory Standards Institute (CLSI), Cruz, Cruz, Cumino, Dehdashti, Del Poeta, Dzoyem, Edlind, Espinel-Ingroff, Feldmeier, Gaggi, Hagen, Hong, Hong, Horton, Jarvis, Joffe, Kneale, Lai, Lassègue, Liu, Liu, Loyse, Meiring, Nixon, Oprea, Park, Peiter, Perfect, Prole, Rabjohns, Rajasingham, Rhein, Samantaray, Smith, Spagnuolo, Spitzer, Teng, Téllez-Girón, Zhai, Zhai   +50 more
core   +3 more sources

1,1′-[4-(2,4-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]diethanone

Acta Crystallographica Section E, 2011
In the title compound, C17H17Cl2NO2, the central 1,4-dihydropyridine ring adopts a flattened-boat conformation. The ethanone substituents of the dihydropyridine ring at positions 3 and 5 have synperiplanar (cis) or antiperiplanar (trans) conformations ...
J. Kalyana Sundar, B. Palakshi Reddy, V. Vijayakumar, S. Natarajan, J. Suresh, P. L. Nilantha Lakshman   +5 more
doaj   +1 more source

biobibliogrāfija II [PDF]

, 2015
Latvijas Zinātņu akadēmijas akadēmiķe profesore Vija Zaiga Kluša : biobibliogrāfija II / Latvijas Universitātes Akadēmiskā bibliotēka; sast. Dagnija Ivbule; korektore Gita Bērziņa; maketu veidojusi Baiba Lazdiņa.
Ivbule, Dagnija, LU Akadēmiskā bibliotēka   +1 more
core  

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source