Results 41 to 50 of about 362,486 (169)

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Conformation of 1,4‐dihydropyridine — planar or boat‐like? [PDF]

FEBS Letters, 1988
The geometry of the 1,4‐dihydropyridine molecule was completely optimized employing three different ab initio basis sets (6–31 G*, 4–31 G, STO—3G). The most reliable 6–31G* basis set provides a very flat boat conformation which may easily undergo defolding to a planar ring arrangement.
H. Hofmann, CIMIRAGLIA, Renzo
openaire   +2 more sources

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Recent Advances in Site‐ and Stereocontrolled Selective Light‐Mediated Functionalizations of Monosaccharide Derivatives

ChemPhotoChem, Volume 10, Issue 10, October 2026.
Once regarded as highly reactive and difficult‐to‐control intermediates, monosaccharide‐derived radicals have emerged as powerful tools for selective synthesis. This review highlights how modern photocatalytic strategies enable the controlled generation of these radicals and their highly regio‐ and stereoselective transformation into structurally ...
Corentin Lefebvre, Norbert Hoffmann
wiley   +1 more source

Synthesis of USP Grade [2,3,7‐13C3]‐Nicotinamide for Human Pharmacokinetic Studies

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 12, October 2026.
We prepared a 17.8‐g quantity of [2,3,7‐13C3]‐nicotinamide in five synthetic steps, with a 42% overall yield, and purified it to > 99% homogeneity, meeting USP standards for oral pharmaceutical dosing. This material is intended for tracking the movement and metabolism of nicotinamide through the human body.
Bruce G. Szczepankiewicz, Karsten J. Koppetsch, Michael P. Drolet, David Cao, Jonathan N. Kremsky, Eric E. Buck, George Rotsides, Greg Griffin, Siead Zegar, Alan Henderson, David J. Livingston   +10 more
wiley   +1 more source

Oxidation of Hantzsch 1,4- Dihydropyridines to Pyridines with Thallium Triacetate [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2003
Hantzsch 1, 4-dihydropyridines (1,4-DHPs) can be oxidized to the corresponding pyridine derivatives by thallium triacetate in high yields.
Mohammad Mahmoodi Hashemi, Mohammad Sadegh Zakeri, Saeed Arianfar   +2 more
doaj  

Smart cellulose‐based room temperature phosphorescent materials: From mechanisms to construction strategies and applications

Smart Molecules, Volume 4, Issue 3, September 2026.
This review elucidates the photophysical mechanisms of cellulose‐based room temperature phosphorescent materials and systematically outlines their construction strategies, such as cluster emission center engineering. This article demonstrates their applications in fields like information encryption and bioimaging, and looks ahead to the core challenges
Shasha Wu, Yifan Zhou, Wanjin Wu, Yan Tang, Mengfan Jing, Jianyu Zhang, Haoke Zhang, Zheng Zhao, Junwei Wang, Laurent Maron, Lijie Liu   +10 more
wiley   +1 more source

Regio and enantioselective synthesis of 4-carbomethoxymethyl-1,4 dihydropyridines

, 1994
Regio and enantioselective 1,4 addition of ethoxyvinyl copper reagent on a pyridine bearing in position 3 a chiral aminal is described.
Raussou, Sabine, Alexakis, Alexandre, Sabine Raussou, Alexandre Alexakis, Gosmini, Romain, Romain Gosmini, Pierre Mangeney, Mangeney, Pierre, Monique Commerçon, Commerçon, Monique   +9 more
core   +1 more source

Benign synthesis of therapeutic agents: domino synthesis of unsymmetrical 1,4-diaryl-1,4-dihydropyridines in the ball-mill

Green Chemistry Letters and Reviews, 2022
The solvent-free preparation of unsymmetrical N-aryl-5,6-unsubstituted-1,4-dihydropyridines (DHPs) by ball-milling was investigated. Three different mechanochemical domino reactions (one-pot/one step or stepwise) were studied, the process parameters ...
Cristina Blazquez-Barbadillo, Juan Francisco González, Andrea Porcheddu, David Virieux, José Carlos Menéndez, Evelina Colacino   +5 more
doaj   +1 more source