Results 1 to 10 of about 13,329 (110)

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects [PDF]

Frontiers in Chemistry
Dihydroquercetin (DHQ) is a representative of flavonoids that is available on the market as a food supplement and registered as an active pharmaceutical ingredient.
Roman Terekhov, Sergey Zavadskiy, Irina Selivanova   +2 more
exaly   +4 more sources

Stereoisomerism of multi-functional electrolyte additives for initially anodeless aqueous zinc metal batteries [PDF]

Nature Communications
Stereoisomerism, arising from the distinctive spatial arrangements of atoms despite identical molecular formulae, often displays different chemical reactivities.
Shengyang Huang, Hao Fu, Hyun Min Kwon, Min Sung Kim, Jun-Dong Zhang, Jun Lu, Jun Su Kim, Gun Jang, Dong Hyun Min, Won Il Kim, Guanyao Wang, Wenwu Li, Rui Zhang, Sae Byeok Jo, Xiang Chen, Qiang Zhang, Kang Xu, Michel Armand, Ho Seok Park   +18 more
doaj   +2 more sources

Stereochemically-aware bioactivity descriptors for uncharacterized chemical compounds [PDF]

Journal of Cheminformatics
Stereochemistry plays a fundamental role in pharmacology. Here, we systematically investigate the relationship between stereoisomerism and bioactivity on over 1 M compounds, finding that a very significant fraction (~ 40%) of spatial isomer pairs show ...
Arnau Comajuncosa-Creus, Aksel Lenes, Miguel Sánchez-Palomino, Dylan Dalton, Patrick Aloy   +4 more
doaj   +2 more sources

Efficacy of Different Doses of Cisatracurium for Intubation during Surgeries under General Anaesthesia- A Randomised Clinical Study [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Cisatracurium is a new non depolarising, Neuromuscular Blocking Drug (NMBD) with fast onset and short duration of action. It is a stereoisomer of atracurium with a potency of approximately three to four times greater than that of atracurium.
Sana Ahmed Shaikh, Arati Bhaskar Jadhav, Archita Rajaram Patil, Anupama Deepak Sahasrabudhe   +3 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)

Pharmaceuticals, 2022
Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic amino moiety (2-aza-bicyclo[2.2.1]heptane) were designed using molecular modelling methods, synthesised, and found to be potent DPP-4 (dipeptidyl ...
Ivan O. Maslov, Tatiana V. Zinevich, Olga G. Kirichenko, Mikhail V. Trukhan, Sergey V. Shorshnev, Natalya O. Tuaeva, Maxim A. Gureev, Amelia D. Dahlén, Yuri B. Porozov, Helgi B. Schiöth, Vladimir M. Trukhan   +10 more
doaj   +1 more source

Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment

Pharmaceutics, 2023
This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard, Frédéric Marçon   +4 more
doaj   +1 more source

First Trifluoromethylated Phenanthrolinediamides: Synthesis, Structure, Stereodynamics and Complexation with Ln(III)

Molecules, 2022
The first examples of 1,10-phenanthroline-2,9-diamides bearing CF3-groups on the side amide substituents were synthesized. Due to stereoisomerism and amide rotation, such complexes have complicated behavior in solutions. Using advanced NMR techniques and
Yuri A. Ustynyuk, Pavel S. Lemport, Vitaly A. Roznyatovsky, Konstantin A. Lyssenko, Alexey O. Gudovannyy, Petr I. Matveev, Ennie K. Khult, Mariia V. Evsiunina, Vladimir G. Petrov, Igor P. Gloriozov, Anton S. Pozdeev, Valentine S. Petrov, Nane A. Avagyan, Alexander S. Aldoshin, Stepan N. Kalmykov, Valentine G. Nenajdenko   +15 more
doaj   +1 more source

Stereoselectivity in spontaneous assembly of rolled incommensurate carbon bilayers

Nature Communications, 2021
Incommensurate pairing is a type of stereoisomerism, observed in carbon bilayers, that arises from the twisted orientations of the graphitic layers. Here, the authors create a finite molecular version of an incommensurate carbon bilayer in the form of ...
Taisuke Matsuno, Yutaro Ohtomo, Maki Someya, Hiroyuki Isobe   +3 more
doaj   +1 more source

“Polytopal Rearrangement Model of Stereoisomerization” and Its Potential as the Basis for a Systematic Model of All Stereoisomerism [PDF]

ACS Organic & Inorganic Au
Peter J. Canfield, Jeffrey R. Reimers, Maxwell J. Crossley   +2 more
doaj   +2 more sources

Development of an open-source software for isomer enumeration

Journal of Cheminformatics, 2023
This article documents enu, a freely-downloadable, open-source and stand-alone program written in C++ for the enumeration of the constitutional isomers and stereoisomers of a molecular formula.
Salomé R. Rieder, Marina P. Oliveira, Sereina Riniker, Philippe H. Hünenberger   +3 more
doaj   +1 more source