Results 1 to 10 of about 35,698 (262)

Antifreeze glycopeptide diastereomers [PDF]

Beilstein Journal of Organic Chemistry, 2012
Antifreeze glycopeptides (AFGPs) are a special class of biological antifreeze agents, which possess the property to inhibit ice growth in the body fluids of arctic and antarctic fish and, thus, enable life under these harsh conditions. AFGPs are composed
Lilly Nagel, Carsten Budke, Axel Dreyer, Thomas Koop, Norbert Sewald   +4 more
doaj   +3 more sources

Field-induced diastereomers for chiral separation [PDF]

Physical Review Letters, 2019
A novel approach for the state-specific enantiomeric enrichment and the spatial separation of enantiomers is presented. Our scheme utilizes techniques from strong-field laser physics, specifically an optical centrifuge in conjunction with a static ...
Küpper, Jochen, Onvlee, Jolijn, Owens, Alec, Yachmenev, Andrey, Zak, Emil   +4 more
core   +8 more sources

Biodegradability and toxicity of monorhamnolipid biosurfactant diastereomers [PDF]

Journal of Hazardous Materials, 2019
Synthetic monorhamnolipids differ from biologically produced material because they are produced as single congeners, depending on the β-hydroxyalkanoic acid used during synthesis. Each congener is produced as one of four possible diastereomers resulting from two chiral centers at the carbinols of the lipid tails [(R,R), (R,S), (S,R) and (S,S)].
David E Hogan, Christopher I Olivares, Ricardo Palos Pacheco   +2 more
exaly   +3 more sources

Mass–Energy Profiles Obtained by Quantum Chemical Computing Applied in Mass Spectrometry: A Case Study with Identification of a Group of Acetalized Monosaccharide Isomers

Applied Sciences, 2023
Accurate modeling of small molecules substantially reduces the logistical effort and time consumption to discover and then obtain chemicals with various applications.
Carolina Cojocariu, Nicolae Dinca, Marius Georgescu, Eugen Sisu, Alina Serb, Mihai-Cosmin Pascariu   +5 more
doaj   +1 more source

Structure–Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of rac-5β-Hydroxy-d-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action

Molecules, 2021
An efficient synthesis of rac-6-desmethyl-5β–hydroxy-d-secoartemisinin 2, a tricyclic analog of R-(+)-artemisinin 1, was accomplished and the racemate was resolved into the (+)-2b and (−)-2a enantiomers via their Mosher Ester diastereomers.
Mohamed Jahan, Francisco Leon, Frank R. Fronczek, Khaled M. Elokely, John Rimoldi, Shabana I. Khan, Mitchell A. Avery   +6 more
doaj   +1 more source

Screening of Novel Antimicrobial Diastereomers of Azithromycin–Thiosemicarbazone Conjugates: A Combined LC-SPE/Cryo NMR, MS/MS and Molecular Modeling Approach

Antibiotics, 2022
A well-known class of antibacterials, 14- and 15-membered macrolides are widely prescribed to treat upper and lower respiratory tract infections. Azithromycin is a 15-membered macrolide antibiotic possessing a broad spectrum of antibacterial potency and ...
Iva Habinovec, Ivana Mikulandra, Paula Pranjić, Saša Kazazić, Hana Čipčić Paljetak, Antun Barišić, Branimir Bertoša, Mirjana Bukvić, Predrag Novak   +8 more
doaj   +1 more source

The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review

Frontiers in Pharmacology, 2022
Mitragynine, is a naturally occurring indole alkaloid that can be isolated from the leaves of a psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to possess promising analgesic effects on mediating the opioid receptors such
Thiruventhan Karunakaran, Thiruventhan Karunakaran, Kok Zhuo Ngew, Kok Zhuo Ngew, Ahmad Alif Danial Zailan, Vivien Yi Mian Jong, Mohamad Hafizi Abu Bakar   +6 more
doaj   +1 more source

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

Molecules, 2023
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists.
Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice   +12 more
doaj   +1 more source

Stereochemistry of the peroxisomal branched-chain fatty acid α- and β-oxidation systems in patients suffering from different peroxisomal disorders

Journal of Lipid Research, 2002
Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid derived from dietary sources and broken down in the peroxisome to pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) via α-oxidation.
S. Ferdinandusse, H. Rusch, A.E.M. van Lint, G. Dacremont, R.J.A. Wanders, P. Vreken   +5 more
doaj   +1 more source

A High-Affinity ⁶⁴Cu-Labeled Ligand for PET Imaging of Hepsin: Design, Synthesis, and Characterization

Pharmaceuticals, 2022
Hepsin, a cell surface serine protease, is a potential biomarker for the detection of prostate cancer due to its high expression in prostate cancer but not in normal prostate.
Ji-Hun Park, Xuran Zhang, Hyunsoo Ha, Jung Young Kim, Joon Young Choi, Kyung-Han Lee, Youngjoo Byun, Yearn Seong Choe   +7 more
doaj   +1 more source