Results 1 to 10 of about 29,843 (119)

Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Molecules, 2022
The knowledge that natural products (NPs) are potent and selective modulators of important biomacromolecules (e.g., DNA and proteins) has inspired some of the world’s most successful pharmaceuticals and agrochemicals.
Hua Zhang, Hua Zhang, Rob Capon
exaly   +3 more sources

Chiral drugs - a standard or a challenge for modern pharmacy? Considerations on selected derivatives of 2-arylpropionic acid. [PDF]

Farmacja Polska, 2022
: The US Food and Drug Administration (FDA) stated in 1992, which drew attention to the importance of chiral drugs. Enantiomers, which are optical isomers of a molecule with a stereogenic center, most often have different pharmacological and ...
Natalia Kocot, Rafał Mastalerz, Jacek Dulęba, Tomasz Siódmiak, Michał Piotr Marszałł   +4 more
doaj   +1 more source

Asymmetric Total Syntheses of Both Enantiomers of Plymuthipyranone B and Its Unnatural Analogues: Evaluation of anti-MRSA Activity and Its Chiral Discrimination

Pharmaceuticals, 2021
Chiral total syntheses of both enantiomers of the anti-MRSA active plymuthipyranone B and all of the both enantiomers of three unnatural and synthetic analogues were performed.
Mizuki Moriyama, Xiaoxi Liu, Yuki Enoki, Kazuaki Matsumoto, Yoo Tanabe   +4 more
doaj   +1 more source

Enantioselective Interactions of Anti-Infective 8-Aminoquinoline Therapeutics with Human Monoamine Oxidases A and B

Pharmaceuticals, 2021
8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been ...
Narayan D. Chaurasiya, Haining Liu, Robert J. Doerksen, N. P. Dhammika Nanayakkara, Larry A. Walker, Babu L. Tekwani   +5 more
doaj   +1 more source

Enantioselectivity in Drug Pharmacokinetics and Toxicity: Pharmacological Relevance and Analytical Methods

Molecules, 2021
Enzymes, receptors, and other binding molecules in biological processes can recognize enantiomers as different molecular entities, due to their different dissociation constants, leading to diverse responses in biological processes. Enantioselectivity can
Maria Miguel Coelho, Carla Fernandes, Fernando Remião, Maria Elizabeth Tiritan   +3 more
doaj   +1 more source

Chiral Flavonoids as Antitumor Agents

Pharmaceuticals, 2021
Flavonoids are a group of natural products with a great structural diversity, widely distributed in plant kingdom. They play an important role in plant growth, development and defense against aggressors.
Cláudia Pinto, Honorina Cidade, Madalena Pinto, Maria Elizabeth Tiritan   +3 more
doaj   +1 more source

Bioactive Indolyl Diketopiperazines from the Marine Derived Endophytic Aspergillus versicolor DY180635

Marine Drugs, 2020
Four new indolyl diketopiperazines, aspamides A–E (1–4) and two new diketopiperazines, aspamides F–G (5–6), along with 11 known diketopiperazines and intermediates were isolated from the solid culture of Aspergillus versicolor, which is an endophyte with
Yi Ding, Xiaojing Zhu, Liling Hao, Mengyao Zhao, Qiang Hua, Faliang An   +5 more
doaj   +1 more source

Metabolism of Cathinones in Functional Hepatocyte-like Cells Derived from Human Neonatal Mesenchymal Stem Cells: An Enantioselectivity Approach

Medical Sciences Forum, 2022
Liver damage is a common issue associated with synthetic cathinones abuse. Indeed, human stem cell-derived hepatocyte-like cells (HLCs) have been used as alternative in vitro models for hepatotoxicity studies, due to their ability to maintain a stable ...
Barbara Silva, Joana Saraiva Rodrigues, Joana Paiva Miranda, Ana Sofia Almeida, Carla Fernandes, Paula Guedes de Pinho, Fernando Remião   +6 more
doaj   +1 more source

Profiling the Nematicidal Activity of Linear and Cyclic Compounds on the Pinewood Nematode

Chemistry Proceedings, 2021
The pinewood nematode (PWN), Bursaphelenchus xylophilus, has become one of the most damaging pests to forest health in Asia and Europe. In the screening for sustainable biopesticides, research has focused on highly active secondary metabolites.
Jorge M. S. Faria, Pedro Barbosa, Cristina Moiteiro, Manuel Mota, Maria L. Inácio   +4 more
doaj   +1 more source

The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
About half of the drugs currently produced are chiral compounds, and about 90 % of these compounds are sold as racemates, consisting of an equimolar mixture of two enantiomers.
Ye. O. Karpun, S. O. Borsuk, L. I. Kucherenko, V. V. Parchenko   +3 more
doaj   +1 more source