Results 21 to 30 of about 55,056 (232)

Enantioseparation and stereoselective dissipation of the novel chiral fungicide pydiflumetofen by ultra-high-performance liquid chromatography tandem mass spectrometry

Ecotoxicology and Environmental Safety, 2021
Pydiflumetofen is a novel and efficient broad-spectrum chiral fungicide consisting of a pair of enantiomers. A simple and sensitive chiral analytical method was established to determine the enantiomers of this chiral fungicide in food and environmental ...
Zhen Wang, Shiling Liu, Xuejun Zhao, Baohua Tian, Xiaofang Sun, Jing Zhang, Yingying Gao, Haiyan Shi, Minghua Wang   +8 more
doaj   +1 more source

Cromatografia gasosa quiral na resolução de enantiômeros envolvidos em flavours de frutas

Química Nova, 2014
This work addresses the use of chiral gas chromatography in resolving optically active stereoisomers and racemates found in fruit flavours. It presents the types of chiral selectors applied to terpene-derived metal coordination compounds, polysiloxane ...
Alexandre Porte, Luciana H. Maia Porte, Luciana M. de Oliveira   +2 more
doaj   +1 more source

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Frontiers in Pharmacology, 2022
Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders.
Asher L. Brandt, Sumanta Garai, Ayat Zagzoog, Dow P. Hurst, Lesley A. Stevenson, Roger G. Pertwee, Gregory H. Imler, Patricia H. Reggio, Ganesh A. Thakur, Robert B. Laprairie, Robert B. Laprairie   +10 more
doaj   +1 more source

Effect of Cd/Cu on the toxicity and stereoselective environmental behavior of dinotefuran in earthworms Eisenia foetida

Ecotoxicology and Environmental Safety, 2023
Pesticides and heavy metals commonly coexist in soil. In this study, the influence of Cd and Cu on the toxicity of rac-dinotefuran and the enantioselective behavior of dinotefuran enantiomers in soil-earthworm microcosms were investigated.
Yirong Zhang, Zhenchao Tan, Kaikai Qin, Chenglan Liu   +3 more
doaj   +1 more source

(±)-Peniorthoesters A and B, Two Pairs of Novel Spiro-Orthoester en-antiomers With an Unusual 1,4,6-Trioxaspi-ro[4.5]decane-7-One Unit From Penicillium minioluteum

Frontiers in Chemistry, 2018
(±)-Peniorthoesters A and B (±1 and ±2), two pairs of unprecedented spiro-orthoester enantiomers with a 1,4,6-trioxaspiro[4. 5]decane-7-one unit, were obtained from Penicillium minioluteum. Their structures were determined by spectroscopic methods, X-ray
Xiaorui Liu, Chunmei Chen, Yinyu Zheng, Mi Zhang, Qingyi Tong, Junjun Liu, Qun Zhou, Jianping Wang, Zengwei Luo, Hucheng Zhu, Yonghui Zhang   +10 more
doaj   +1 more source

Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor. [PDF]

PLoS ONE, 2014
Azole antifungal ketoconazole (KET) was demonstrated to activate aryl hydrocarbon receptor (AhR). Since clinically used KET is a racemic mixture of two cis-enantiomers (2R,4S)-(+)-KET and (2S,4R)-(-)-KET, we examined the effects of KET enantiomers on AhR
Aneta Novotna, Martina Korhonova, Iveta Bartonkova, Anatoly A Soshilov, Michael S Denison, Katerina Bogdanova, Milan Kolar, Petr Bednar, Zdenek Dvorak   +8 more
doaj   +1 more source

Enantioselective Monitoring of Biodegradation of Ketamine and Its Metabolite Norketamine by Liquid Chromatography

Chemosensors, 2021
Ketamine (K) and its main metabolite, norketamine (NK), are chiral compounds that have been found in effluents from wastewater treatment plants (WWTPs) and aquatic environments.
Ariana Pérez-Pereira, Alexandra Maia, Virgínia Gonçalves, Cláudia Ribeiro, Maria Elizabeth Tiritan   +4 more
doaj   +1 more source

Enantioselectivity of chiral dihydromyricetin in multicomponent solid solutions regulated by subtle structural mutation

IUCrJ, 2023
Multicomponent crystals of a chiral drug with non-chiral components have attracted increasing attention in the application of enantiomer purification and regulation of the physicochemical properties of crystalline materials.
Jie Sun, Yaoguo Wang, Weiwei Tang, Junbo Gong   +3 more
doaj   +1 more source

AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volunteers

Acta Pharmaceutica, 2019
The relative contribution of CYP2C9 allelic variants to the pharmacokinetics (PK) of ibuprofen (IBP) enantiomers has been studied extensively, but the potential clinical benefit of pharmacogenetically guided IBP treatment is not evident yet.
Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar   +7 more
doaj   +1 more source

Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Molecules, 2017
Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers.
Kristyna Krasulova, Ondrej Holas, Pavel Anzenbacher   +2 more
doaj   +1 more source