Results 31 to 40 of about 56,768 (286)

Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Molecules, 2017
Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers.
Kristyna Krasulova, Ondrej Holas, Pavel Anzenbacher   +2 more
doaj   +1 more source

Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients [PDF]

, 2016
Praziquantel (PZQ) is the treatment of choice for infections with the liver fluke Opisthorchis viverrini, a major health problem in Southeast Asia. However, pharmacokinetic (PK) studies investigating the disposition of PZQ enantiomers (R- and S-PZQ) and ...
Jennifer Keiser, Urs Duthaler, Jörg Huwyler, Meister, Isabel, Jana Kovac, Odermatt, Peter, Kovac, Jana, Vanobberghen, Fiona, Peter Odermatt, Somphou Sayasone, Fiona Vanobberghen, Huwyler, Jörg, Sayasone, Somphou, Keiser, Jennifer, Isabel Meister, Duthaler, Urs, Meister I, Keiser J, Sayasone S, Odermatt Peter, Vanobberghen F, Kovac Jana, Huwyler J, Duthaler Urs, Keiser Jennifer, Odermatt P, Huwyler Jörg, Sayasone Somphou, Duthaler U, Vanobberghen Fiona, Kovac J, Meister Isabel   +31 more
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Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction

Molecules, 2021
This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds.
Mufarreh Asmari, Xiaoyu Wang, Natalia Casado, Marjan Piponski, Sergiy Kovalenko, Liliya Logoyda, Rasha Sayed Hanafi, Sami El Deeb   +7 more
doaj   +1 more source

Application of Natural and Modified Biomacromolecules in Miniaturised Separative Analytical Techniques [PDF]

In pharmaceutical R & D, drug stereochemistry, and consequently the rotation of enantiomers, is very important. Because they act as chiral selectors in vivo, biomacromolecules have been extensively used as chiral selectors for the liquid chromatographic (
Salmon, Andrew B
core   +5 more sources

Diastereoisomer-Specific Biotransformation of Hexabromocyclododecanes by a Mixed Culture Containing Dehalococcoides mccartyi Strain 195

Frontiers in Microbiology, 2018
Hexabromocyclododecane (HBCD) stereoisomers may exhibit substantial differences in physicochemical, biological, and toxicological properties. However, there remains a lack of knowledge about stereoisomer-specific toxicity, metabolism, and environmental ...
Yin Zhong, Heli Wang, Heli Wang, Zhiqiang Yu, Xinhua Geng, Chengyu Chen, Dan Li, Dan Li, Xifen Zhu, Xifen Zhu, Huajun Zhen, Weilin Huang, Donna E. Fennell, Lily Y. Young, Ping’an Peng, Ping’an Peng   +15 more
doaj   +1 more source

Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held together ...
I. Caroline Vaaland, Óscar López, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck   +7 more
doaj   +1 more source

enantiomer [PDF]

, 2014
Citation: 'enantiomer' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.E02069 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Nicotine enantiomers and their pharmacological properties.

, 2022
Nicotine enantiomers and their pharmacological properties.
Susan Plunkett (12419128), Bonnie G. Coffa (12419137), Jacob Hilldrup (12419134), Steve Eckard (12419143), Andrew G. Cheetham (1309746), Preston Campbell (12419131), Stan Gilliland III (12419140)   +6 more
core   +1 more source

Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells

Pharmaceuticals, 2022
Pentedrone and methylone can express stereoselectivity in toxicokinetic and toxicodynamic processes. Similarly, their chiral discrimination in metabolism, which was not yet evaluated, can result in different metabolic profiles and subsequent hepatotoxic ...
Bárbara Silva, Joana Saraiva Rodrigues, Ana Sofia Almeida, Ana Rita Lima, Carla Fernandes, Paula Guedes de Pinho, Joana Paiva Miranda, Fernando Remião   +7 more
doaj   +1 more source

Cytotoxicity of enantiomers of gossypol [PDF]

British Journal of Cancer, 1986
The effect of gossypol on cell proliferation was studied using 24-well multiwell dishes. Cells were added to each well and incubated for 24 hours before the addition of different concentration of gossypol which was dissolved in dimethyl sulfoxide immediately prior to use.
A E, Joseph, S A, Matlin, P, Knox
openaire   +2 more sources