Results 31 to 40 of about 55,056 (232)

Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction

Molecules, 2021
This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds.
Mufarreh Asmari, Xiaoyu Wang, Natalia Casado, Marjan Piponski, Sergiy Kovalenko, Liliya Logoyda, Rasha Sayed Hanafi, Sami El Deeb   +7 more
doaj   +1 more source

Diastereoisomer-Specific Biotransformation of Hexabromocyclododecanes by a Mixed Culture Containing Dehalococcoides mccartyi Strain 195

Frontiers in Microbiology, 2018
Hexabromocyclododecane (HBCD) stereoisomers may exhibit substantial differences in physicochemical, biological, and toxicological properties. However, there remains a lack of knowledge about stereoisomer-specific toxicity, metabolism, and environmental ...
Yin Zhong, Heli Wang, Heli Wang, Zhiqiang Yu, Xinhua Geng, Chengyu Chen, Dan Li, Dan Li, Xifen Zhu, Xifen Zhu, Huajun Zhen, Weilin Huang, Donna E. Fennell, Lily Y. Young, Ping’an Peng, Ping’an Peng   +15 more
doaj   +1 more source

Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held together ...
I. Caroline Vaaland, Óscar López, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck   +7 more
doaj   +1 more source

Enhanced mechanical and thermal strength in mixed enantiomers based supramolecular gel [PDF]

, 2018
Mixing supramolecular gels based on enantiomers leads to re-arrangement of gel fibers at the molecular level, which results in more favorable packing and tuneable properties.
António A. Vicente (5855534), Vicente, A. A., Dipankar Ghosh (5855525), Martin, Adam D., Daníel Arnar Tómasson (5855522), Adam D. Martin (831175), Damodaran, Krishna Kumar, Tómasson, Daníel Arnar, Fasolin, Luiz H., Ghosh, Dipankar, Thordarson, Pall, Krishna K. Damodaran (5855537), Luiz Henrique Fasolin (5855531), Zala Kržišnik (5855528), Krinik, Zala, Pall Thordarson (651624)   +15 more
core   +1 more source

Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells

Pharmaceuticals, 2022
Pentedrone and methylone can express stereoselectivity in toxicokinetic and toxicodynamic processes. Similarly, their chiral discrimination in metabolism, which was not yet evaluated, can result in different metabolic profiles and subsequent hepatotoxic ...
Bárbara Silva, Joana Saraiva Rodrigues, Ana Sofia Almeida, Ana Rita Lima, Carla Fernandes, Paula Guedes de Pinho, Joana Paiva Miranda, Fernando Remião   +7 more
doaj   +1 more source

Enantiomeric separation of four pairs of alkaloids by using a C18 column tandem polysaccharide-based chiral column

Reviews in Analytical Chemistry
Alkaloid enantiomers have different physiological and pharmacological effects, and different chiral compositions have a large impact on cigarette sensory and use safety.
Si Xiaoxi, Tian Yu, Xu Shufang, Liu Chunbo, Li Zhenjie, Yang Ji, Guan Ying, Xie Yangzhou, Shi Xiaoqing, Xu Zhigang, Liu Zhihua   +10 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Isolation of enantiomers via diastereomer crystallisation [PDF]

, 2010
Enantiomer separation remains an important technique for obtaining optically active materials. Even though the enantiomers have identical physical properties, the difference in their biological activities make it important to separate them, in order ...
Anandamanoharan, P.
core  

Development of novel chiral capillary electrophoresis methods for the serotonin receptor (5-HT2A) antagonist MDL 100,907 (volinanserin) and for its key intermediate compound [PDF]

, 2014
Enantioselective capillary electrophoretic methods were elaborated for the determination of the enantiomeric purity of (R)-MDL 100,907 and its preparatively resolved key intermediate compound during the synthesis route. The pKa values of the intermediate
Palkó, Roberta, Németh, Krisztina, Benéné Visy, Júlia, Kovács, Péter   +3 more
core   +1 more source

Donor‐Engineered Chiral Indium–Salen Complexes for Tunable Circularly Polarized Luminescence

Advanced Functional Materials, EarlyView.
Chiral indium–salen complexes bearing electronically and structurally diverse donor substituents are presented as modular main‐group luminophores exhibiting tunable blue‐to‐green circularly polarized luminescence. Donor engineering systematically controls frontier‐orbital distribution, intraligand charge transfer, and excited‐state relaxation ...
Haein Kim, Minseo Ji, Khuslen Bazarragchaa, Yubin Choi, Gahyeon Baek, Ji Hye Lee, Heekyung Park, Houng Kang, Hyonseok Hwang, Huiyeong Ju, Jun Hui Park, Youngjo Kim, Min Kim, Youngmin You, Myung Hwan Park   +14 more
wiley   +1 more source