Results 31 to 40 of about 48,807 (291)

Enantioselective Monitoring of Biodegradation of Ketamine and Its Metabolite Norketamine by Liquid Chromatography

Chemosensors, 2021
Ketamine (K) and its main metabolite, norketamine (NK), are chiral compounds that have been found in effluents from wastewater treatment plants (WWTPs) and aquatic environments.
Ariana Pérez-Pereira, Alexandra Maia, Virgínia Gonçalves, Cláudia Ribeiro, Maria Elizabeth Tiritan   +4 more
doaj   +1 more source

Development of novel chiral capillary electrophoresis methods for the serotonin receptor (5-HT2A) antagonist MDL 100,907 (volinanserin) and for its key intermediate compound [PDF]

, 2014
Enantioselective capillary electrophoretic methods were elaborated for the determination of the enantiomeric purity of (R)-MDL 100,907 and its preparatively resolved key intermediate compound during the synthesis route. The pKa values of the intermediate
Palkó, Roberta, Németh, Krisztina, Benéné Visy, Júlia, Kovács, Péter   +3 more
core   +1 more source

Enantioselectivity of chiral dihydromyricetin in multicomponent solid solutions regulated by subtle structural mutation

IUCrJ, 2023
Multicomponent crystals of a chiral drug with non-chiral components have attracted increasing attention in the application of enantiomer purification and regulation of the physicochemical properties of crystalline materials.
Jie Sun, Yaoguo Wang, Weiwei Tang, Junbo Gong   +3 more
doaj   +1 more source

AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volunteers

Acta Pharmaceutica, 2019
The relative contribution of CYP2C9 allelic variants to the pharmacokinetics (PK) of ibuprofen (IBP) enantiomers has been studied extensively, but the potential clinical benefit of pharmacogenetically guided IBP treatment is not evident yet.
Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar   +7 more
doaj   +1 more source

Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Molecules, 2017
Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers.
Kristyna Krasulova, Ondrej Holas, Pavel Anzenbacher   +2 more
doaj   +1 more source

Chiral Inversion of 2-Arylpropionic Acid Enantiomers under Anaerobic Conditions [PDF]

, 2022
This work examined the chiral inversion of 2-arylpropionic acids (2-APAs) under anaerobic conditions and the associated microbial community. The anaerobic condition was simulated by two identical anaerobic digesters.
Quynh Anh Nguyen, Vu, Hang P, Nguyen, Luong N, Hang P. Vu, McDonald, James A, Long D. Nghiem, Peta A. Neale, James A. McDonald, Khan, Stuart J, Nguyen, QA, Nghiem, Long D, Luong N. Nguyen, Nghiem, LD, Neale, Peta A, Neale, PA, Leusch, FDL, Leusch, Frederic DL, Frederic D.L. Leusch, Stuart J. Khan, McDonald, JA, Nguyen, LN, Vu, HP, Khan, SJ, Quynh, Anh Nguyen   +23 more
core   +1 more source

Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction

Molecules, 2021
This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds.
Mufarreh Asmari, Xiaoyu Wang, Natalia Casado, Marjan Piponski, Sergiy Kovalenko, Liliya Logoyda, Rasha Sayed Hanafi, Sami El Deeb   +7 more
doaj   +1 more source

Cytotoxicity evaluation of three pairs of hexabromocyclododecane (HBCD) enantiomers on Hep G2 cell [PDF]

, 2008
Hexabromocyclododecanes (HBCDs) are additive brominated flame retardants mainly used in plastics and textiles. At the present time, these compounds are found in almost all environmental and human samples. In order to evaluate the environmental safety and
Wen, Sheng, Zhang, Xiaoling, Liu, Weiping, Xu, Y, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, 7 Donghu S Rd, Wuhan 430072, Peoples R China, Xu, Ying, Xu, Chao, Yang, Fangxing   +6 more
core   +1 more source

Diastereoisomer-Specific Biotransformation of Hexabromocyclododecanes by a Mixed Culture Containing Dehalococcoides mccartyi Strain 195

Frontiers in Microbiology, 2018
Hexabromocyclododecane (HBCD) stereoisomers may exhibit substantial differences in physicochemical, biological, and toxicological properties. However, there remains a lack of knowledge about stereoisomer-specific toxicity, metabolism, and environmental ...
Yin Zhong, Heli Wang, Heli Wang, Zhiqiang Yu, Xinhua Geng, Chengyu Chen, Dan Li, Dan Li, Xifen Zhu, Xifen Zhu, Huajun Zhen, Weilin Huang, Donna E. Fennell, Lily Y. Young, Ping’an Peng, Ping’an Peng   +15 more
doaj   +1 more source

Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held together ...
I. Caroline Vaaland, Óscar López, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck   +7 more
doaj   +1 more source