Molecules, 2023 Despite the fact that the self-disproportionation of enantiomers (SDE) has been found for several decades and has been widely used in crystallization, sublimation and chromatography for the purification or separation of nonracemic compounds, the ...
Shaoqiang Hu
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The separation of specific enantiomers of anticancer reagent cytarabine using HPLC. [PDF]
During the research and development stage of any drug candidate, there is a growing need to investigate the properties of existing enantiomers, if the drug possesses chirality.
Kamble, Shweta Ashok
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Application of Natural and Modified Biomacromolecules in Miniaturised Separative Analytical Techniques [PDF]
In pharmaceutical R & D, drug stereochemistry, and consequently the rotation of enantiomers, is very important. Because they act as chiral selectors in vivo, biomacromolecules have been extensively used as chiral selectors for the liquid chromatographic (
Salmon, Andrew B
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MODULATION OF CALCIUM CHANNELS IN ARTERIAL SMOOTH-MUSCLE CELLS BY DIHYDROPYRIDINE ENANTIOMERS [PDF]
, 1993 The actions of the optical enantiomers of BAY K 8644 and Sandoz 202,791 were studied on barium inward currents recorded using the whole-cell configuration of the patch clamp technique from enzymatically isolated smooth muscle cells from the rabbit ear ...
S Hering +7 more
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Frontiers in Marine Science, 2015 Amino acid (AA) compositions were determined for bacteria-sized particles and particulate organic matter (POM) collected in offshore regions of the western North Pacific.
Hiroyuki eTakasu, Toshi eNagata
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Ecotoxicology and Environmental Safety, 2021 Enantiomers of chiral fungicides usually display different toxic effects on nontarget organisms in the surrounding environment, although there are rare reports on the enantioselective toxicity of metconazole (MEZ) to aquatic organisms, such as ...
Ling Li, Peiling Huang, Junjie Li
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Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements [PDF]
, 2012 Starting from a mixture of enantiomers in solution, crystallization can generate different types of crystals. In order to determine which type of crystal is obtained in the case of acetylleucine, an active pharmaceutical ingredient (API), analytical ...
B. Biscans +9 more
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On the Separation of Enantiomers by Drift Tube Ion Mobility Spectrometry [PDF]
, 2022 Racemic mixtures of twelve common α-amino acids and three chiral drugs were tested for the separation of their enantiomers by drift tube ion mobility spectrometry (IMS)-quadrupole mass spectrometry (QMS) by introducing chiral selectors into the buffer ...
Markus, Doerr +1 more
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Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients [PDF]
, 2016 Praziquantel (PZQ) is the treatment of choice for infections with the liver fluke Opisthorchis viverrini, a major health problem in Southeast Asia. However, pharmacokinetic (PK) studies investigating the disposition of PZQ enantiomers (R- and S-PZQ) and ...
Jennifer Keiser +15 more
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Separation of Enantiomers through Local Vorticity: A Screw Model Mechanism [PDF]
, 2021 We present a model to explain the mechanism behind enantiomeric separation under either shear flow or local rotational motion in a fluid. Local vorticity of the fluid imparts molecular rotation that couples to translational motion, sending enantiomers in
J. Daniel, Gezelter, Anderson, Duraes
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