Results 1 to 10 of about 3,249 (212)

Application of threo-2-amino-1,2-diphenylethanol as a Resolving Agent for Racemic Carboxylic Acids via Diastereomeric Salt Formation. [PDF]

Chirality
The ability of threo‐2‐amino‐1,2‐diphenylethanol as a resolving agent for carboxylic acids via diastereomeric salt formation was investigated. It exhibited complementary performance to its erythro‐isomer and ortho‐halogenated mandelic acids were efficiently separated.
Kodama K, Katayama K, Hirose T.
europepmc   +2 more sources

Protein-Based High-Performance Liquid Chromatography and Cyclodextrin-Capillary Electrokinetic Chromatography for the Chiral Separation of Azoles. [PDF]

Electrophoresis
Human serum albumin‐based high‐performance liquid chromatography and cyclodextrin‐based capillary electrokinetic chromatography were used for the chiral separation of azoles. Although only two of the five tested azoles could be enantioseparated by liquid chromatography, all of them were separated by capillary electrokinetic chromatography using single ...
Moreau S, Dillon A, Russo G, Wiedmer SK.
europepmc   +2 more sources

Green Chiral HPLC Method for Lumefantrine Analysis: Method Development, Greenness Assessment, and Computational Studies. [PDF]

Chirality
A green chiral HPLC method was developed and validated for the determination of lumefantrine enantiomers. The method employs ethanol as a mobile phase as a sustainable and efficient alternative to hexane. The chiral recognition mechanism and elution order of the enantiomers were investigated using electronic circular dichroism and molecular docking ...
Mohr A, das Neves GM, Segala É, Eifler-Lima VL, Steppe M.   +4 more
europepmc   +2 more sources

Determination of Enantiomers of Deschloroketamine and Its Metabolites in Wistar Rat Brains. [PDF]

J Sep Sci
Although supercritical fluid chromatography coupled to mass spectrometry efficiently resolved deschlorketamine and its metabolites, the parent drug must have been quantified by capillary zone electrophoresis. ABSTRACT Deschloroketamine (DXE) is a dissociative new psychoactive substance whose enantiomers and metabolites may exhibit distinct ...
Paškanová N, Hrubá V, Frühauf P, Jurásek B, Kuchař M, Řezanka P, Kohout M.   +6 more
europepmc   +2 more sources

Chiral HPLC Separation of Phosphonothrixin and Phosphonate Derivatives and Electronic Circular Dichroism Characterization of the Isolated Enantiomers. [PDF]

Electrophoresis
Natural compound phosphonothrixin's herbicidal activity resides exclusively in its (S)‐enantiomer, yet existing enantioselective syntheses are cumbersome, and direct chiral LC separation is hampered by the compound's high polarity, lack of aromatic groups, and metal chelation–induced peak tailing.
Maalouf M, Knab M, Gessner L, Engelhardt M, Friedrich S, Gross H, Boeckler F, Hughes CC, Lämmerhofer M.   +8 more
europepmc   +2 more sources

Probing Chiral Recognition on Amylose Tris(3,5-Dimethylphenylcarbamate) Using Cinnamyl 2-Aminoanilides: The Subtle Impact of Aliphatic Substituents. [PDF]

Electrophoresis
This study investigates how subtle aliphatic substituent differences in racemic cinnamyl 2‐aminoanilides affect chiral recognition on amylose tris(3,5‐dimethylphenylcarbamate). Pronounced enantioselectivity changes arose from minimal structural variations. Mobile phase effects were examined, with 2‐propanol improving resolution.
Kaya SG, Raucci A, Zwergel C, Mai A, Valente S, Cirilli R.   +5 more
europepmc   +2 more sources

Cyclodextrins as Chiral Selectors in Capillary Electrophoresis-Recent Developments in Understanding Analyte Complexation and Applications in Pharmaceutical Analysis. [PDF]

Electrophoresis
Cyclodextrins are the most often applied chiral selectors in CE enantioseparations. In combination with NMR spectroscopy and molecular modeling, studies for an understanding of chiral recognition underlying enantioseparations have been performed.
Scriba GKE.
europepmc   +2 more sources

Progress in the Enantioseparation of β-Blockers by Chromatographic Methods

Molecules, 2021
β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g.,
Yiwen Yang, Qilong Ren, Qiwei Yang
exaly   +3 more sources

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods. [PDF]

Chirality
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Karayavuz B, Kirmizioglu CK.
europepmc   +2 more sources

Enantioselective Determination of Upadacitinib in Pharmaceutical Formulations Using Reversed‐Phase Chiral Liquid Chromatography [PDF]

J Sep Sci
A reversed‐phase chiral HPLC method was developed for the enantioselective separation and quantification of upadacitinib using a Box‐Behnken design. The validated method was successfully applied to the quantification of upadacitinib in a commercial tablet formulation, and its environmental impact and practicality were evaluated using various assessment
Atila Karaca S, Aliyeva S, Yeniceli D.
europepmc   +2 more sources