Results 1 to 10 of about 3,397 (210)

Retention time prediction for chromatographic enantioseparation by quantile geometry-enhanced graph neural network

Nature Communications, 2023
The enantioseparation of chiral molecules is a crucial and challenging task in the field of experimental chemistry, often requiring extensive trial and error with different experimental settings.
Hao Xu, Jinglong Lin, Dongxiao Zhang, Fanyang Mo   +3 more
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Capillary Electrophoretic Enantioseparation of Profens: Advances in Chiral Selectors, Separation Strategies, and Analytical Applications [PDF]

Molecules
Profens are chiral nonsteroidal anti-inflammatory drugs (NSAIDs) whose enantiomers may differ in pharmacokinetics, pharmacological activity and pharmacotoxicological profile, making enantioselective analysis relevant for pharmaceutical quality control ...
Gabriel Hancu, Maria Matean, Anca Gabriela Cârje   +2 more
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Isolation, Characterization, and Stability Assessment of Pure Enantiomers of Cathinone Derivatives via Semi-Preparative HPLC-UV Using a Phenomenex Lux^® 5 Column [PDF]

Molecules
In addition to well-known traditional synthetic illicit drugs like cocaine, amphetamines, and heroin, an increasing number of new psychoactive substances (NPS) are appearing on the global drug market.
Stefanie Handl, Katrin Stelzeneder, Annaluna Ravelli, Martin G. Schmid   +3 more
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Possible Enantioseparation of Racemic Ribose on Chiral Surface Formed by Adsorption of Nucleobases [PDF]

Life
The paper proposes a putative prebiotic scenario leading to homochirality in the RNA world. In this scenario, racemic ribose, the only chiral moiety in RNA, was enantioseparated (in its pyranose form) on a chiral surface formed by the adsorption of ...
Roman Bielski, Michal Tencer
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Unveiling the Power of Computational Tools in Chiral Liquid Chromatography [PDF]

Molecules
Chiral liquid chromatography (cLC) using chiral stationary phases (CSPs) has become a crucial technique for separating enantiomers. Understanding enantiomeric discrimination is essential for improving chromatographic conditions and elucidating chiral ...
Rita Lima, Rui P. P. Neves, Pedro A. Fernandes, Artur M. S. Silva, Carla Fernandes   +4 more
doaj   +2 more sources

Enantioseparation of 5,5′-Dibromo-2,2′-dichloro-3-selanyl-4,4′-bipyridines on Polysaccharide-Based Chiral Stationary Phases: Exploring Chalcogen Bonds in Liquid-Phase Chromatography

Molecules, 2021
The chalcogen bond (ChB) is a noncovalent interaction based on electrophilic features of regions of electron charge density depletion (σ-holes) located on bound atoms of group VI.
Paola Peluso, Alessandro Dessì, Roberto Dallocchio, Barbara Sechi, Carlo Gatti, Bezhan Chankvetadze, Victor Mamane, Robin Weiss, Patrick Pale, Emmanuel Aubert, Sergio Cossu   +10 more
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Enantioseparation of syn- and anti-3,5-Disubstituted Hydantoins by HPLC and SFC on Immobilized Polysaccharides-Based Chiral Stationary Phases

Separations, 2022
The enantioseparation of syn- and anti-3,5-disubstituted hydantoins 5a–i was investigated on three immobilized polysaccharide-based columns (CHIRAL ART Amylose-SA, CHIRAL ART Cellulose-SB, CHIRAL ART Cellulose-SC) by high performance liquid ...
Mladenka Jurin, Darko Kontrec, Tonko Dražić, Marin Roje   +3 more
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Bound States in the Continuum in All‐Dielectric Metasurface: Separation of Sub‐10 nm Enantiomers

Advanced Photonics Research, 2022
Enantioseparation is crucial in pharmaceutics and agrochemicals. Compared to the current chemical technique, the optical enantioseparation is more effective means yet hampered by the weak chiral optical force. Recently, plasmonic nanostructures have been
Libang Mao, Kuan Liu, Meng Lian, Jingyuan Jia, Ying Su, Haonan Ren, Lei-Ming Zhou, Tun Cao   +7 more
doaj   +1 more source

Stationary phases based on the nanoparticles for pharmaceutical and biomolecule separations [PDF]

Nanochemistry Research, 2021
Because of impossibility to achieve a general column for separation purposes, columns must be amended in order to acquire specific chemical characteristics such as hydrophobic, hydrophilic or ionic interactions.
Forough Karami, Somayeh Karami
doaj   +1 more source

Enantioseparation of new axially chiral carboxylic acids on polysaccharide-based chiral stationary phases under normal phase elution conditions

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
In the last decade, the availability of new and versatile synthetic strategies for the preparation of substituted 4,4’-bipyridyl derivatives based on chemo- and regioselective functionalization of the 4,4’-bipyridine core has encouraged studies for ...
Barbara Sechi, Victor Mamane, Roberto Dallocchio, Alessandro Dessì, Sergio Cossu, Giorgi Jibuti, Paola Peluso   +6 more
doaj   +1 more source