Results 31 to 40 of about 3,397 (210)
A Look at the Importance of Chirality in Drug Activity: Some Significative Examples
Applied Sciences, 2022 Chirality plays an important role in the development of many pharmaceuticals, being a general property of ‘handedness’; nevertheless, a large number of pharmaceuticals are still marketed and administered as racemates.
Jessica Ceramella +7 more
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Chemosensors, 2021 Ketamine (K) and its main metabolite, norketamine (NK), are chiral compounds that have been found in effluents from wastewater treatment plants (WWTPs) and aquatic environments.
Ariana Pérez-Pereira +4 more
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Progress in the Enantioseparation of β-Blockers by Chromatographic Methods
Molecules, 2021 β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g.,
Yiwen Yang +5 more
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Arhiv za Higijenu Rada i Toksikologiju, 2020 Beta-blockers are chiral compounds with enantiomers that have different bioactivity, which means that while one is active, the other can be inactive or even harmful.
Pocrnić Marijana +5 more
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Pharmaceuticals, 2022 Analytical-method development based on design of experiment has been applied for optimizing the enantioseparation of amlodipine by chiral capillary electrokinetic chromatography using maltodextrin as the chiral selector.
Ratih Ratih +3 more
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Molecules, 2013 Enantioseparation is largely based on the formation of transitional complexes, the solvation species, the stationary phase configurations or the diastereomeric complexes formed by analytes and the chiral stationary phase.
Hong-Xun Guo, Steven Wu, Jingshun Sun
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Chemosensors, 2022 Metal–organic frameworks (MOFs), as high-surface-area materials, have shown promise in various areas of application, such as chiral sensing and separation, due to their flexibility in design and organized porous cages.
Soodabeh Hassanpour +2 more
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Enantioseparation of chiral phytocannabinoids in medicinal cannabis
Journal of Chromatography B, 2023 The evaluation of the chiral composition of phytocannabinoids in the cannabis plant is particularly important as the pharmacological effects of the (+) and (-) enantiomers of these compounds are completely different. Chromatographic attempts to assess the presence of the minor (+) enantiomers of the main phytocannabinoids, cannabidiolic acid (CBDA) and
Russo, Fabiana +13 more
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Pharmaceuticals, 2021 Chondroitin sulfate A was covalently immobilized onto a monolithic silica epoxy column involving a Schiff base formation in the presence of ethylenediamine as a spacer and evaluated in terms of its selectivity in enantioseparation.
Ratih Ratih +5 more
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Effect of molecular rotation on enantioseparation [PDF]
The Journal of Chemical Physics, 2012 Recently, several laser schemes have been proposed to separate racemic mixtures of enantiomers by splitting a molecular beam into subbeams consisting of molecules of definite chirality [Y. Li, C. Bruder, and C. P. Sun, Phys. Rev. Lett. 99, 130403 (2007)10.1103/PhysRevLett.99.130403; X. Li and M. Shapiro, J. Chem. Phys.
Jacob, Andreas, Hornberger, Klaus
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