Results 11 to 20 of about 2,821 (224)

Retention time prediction for chromatographic enantioseparation by quantile geometry-enhanced graph neural network

Nature Communications, 2023
The enantioseparation of chiral molecules is a crucial and challenging task in the field of experimental chemistry, often requiring extensive trial and error with different experimental settings.
Hao Xu, Jinglong Lin, Dongxiao Zhang, Fanyang Mo   +3 more
doaj   +2 more sources

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods [PDF]

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +2 more sources

HPLC Enantioseparation of Phenylcarbamic Acid Derivatives by Using Macrocyclic Chiral Stationary Phases

Nova Biotechnologica et Chimica, 2016
The HPLC by using chiral stationary phases based on macrocyclic antibiotics, dimethylphenyl carbamate cyklofructan 7 and β-cyclodextrin in terms of polar-organic separation mode (mobile phase methanol/acetonitrile/acetic acid/triethylamine) were used for
Hroboňová Katarína, Lehotay Jozef, Čižmárik Jozef   +2 more
doaj   +2 more sources

Enantioselective Properties of Neglected Drug Nifurtimox on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases by Green HPLC Separation Methods [PDF]

Journal of Separation Science, Volume 48, Issue 9, September 2025.
ABSTRACT Nifurtimox (NFX) is a chiral drug used for the treatment of Chagas Disease. Little attention has been paid to the enantioselective properties of chiral drugs used for neglected tropical diseases, highlighting the need for further studies in this area.
Amanda Mohr, Érika Segala, Gustavo Machado das Neves, Vera Lucia Eifler‐Lima, Martin Steppe   +4 more
wiley   +2 more sources

Evolution of Circularly Polarized Luminescence in Atomically Precise Silver Nanoclusters with Intrinsic Chirality [PDF]

Angewandte Chemie, Volume 137, Issue 45, November 3, 2025.
The rich excited‐state dynamics of intrinsically chiral silver nanoclusters tethering cationic species on the surface demonstrates the excited‐state dependent circularly polarized luminescence (CPL), suggesting the temporal evolution of exciton distribution.
Wataru Ishii, Takafumi Shiraogawa, Masahiro Ehara, Hikaru Sotome, Hiroshi Miyasaka, Tsuyoshi Kawai, Takuya Nakashima   +6 more
wiley   +3 more sources

Possible Enantioseparation of Racemic Ribose on Chiral Surface Formed by Adsorption of Nucleobases [PDF]

Life
The paper proposes a putative prebiotic scenario leading to homochirality in the RNA world. In this scenario, racemic ribose, the only chiral moiety in RNA, was enantioseparated (in its pyranose form) on a chiral surface formed by the adsorption of ...
Roman Bielski, Michal Tencer
doaj   +2 more sources

Unveiling the Power of Computational Tools in Chiral Liquid Chromatography [PDF]

Molecules
Chiral liquid chromatography (cLC) using chiral stationary phases (CSPs) has become a crucial technique for separating enantiomers. Understanding enantiomeric discrimination is essential for improving chromatographic conditions and elucidating chiral ...
Rita Lima, Rui P. P. Neves, Pedro A. Fernandes, Artur M. S. Silva, Carla Fernandes   +4 more
doaj   +2 more sources

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity [PDF]

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Ebru Koçak Aslan, Kevin Lam, Sun Huang, Göknil Pelin Coşkun, Ayşe Karagüzel, Katrin Denzinger, Kaan Birgül, Mert Ülgen, Jordan W. Nafie, Onur Şahin, Daniel W. Armstrong, Gerald W. Zamponi, Gerhard Wolber, Miyase Gözde Gündüz   +13 more
wiley   +2 more sources

Review of Applications of β-Cyclodextrin as a Chiral Selector for Effective Enantioseparation. [PDF]

Int J Mol Sci
The significance and necessity of separating enantiomers in food, pharmaceuticals, pesticides, and other samples remains constant and unrelenting. The successful chiral separation usually includes the application of a chiral auxiliary compound, known ...
Napiórkowska E, Szeleszczuk Ł.
europepmc   +2 more sources

Enantioseparation of 5,5′-Dibromo-2,2′-dichloro-3-selanyl-4,4′-bipyridines on Polysaccharide-Based Chiral Stationary Phases: Exploring Chalcogen Bonds in Liquid-Phase Chromatography

Molecules, 2021
The chalcogen bond (ChB) is a noncovalent interaction based on electrophilic features of regions of electron charge density depletion (σ-holes) located on bound atoms of group VI.
Paola Peluso, Alessandro Dessì, Roberto Dallocchio, Barbara Sechi, Carlo Gatti, Bezhan Chankvetadze, Victor Mamane, Robin Weiss, Patrick Pale, Emmanuel Aubert, Sergio Cossu   +10 more
doaj   +1 more source