Results 11 to 20 of about 5,412 (216)

Enantioselective Properties of Neglected Drug Nifurtimox on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases by Green HPLC Separation Methods. [PDF]

J Sep Sci
ABSTRACT Nifurtimox (NFX) is a chiral drug used for the treatment of Chagas Disease. Little attention has been paid to the enantioselective properties of chiral drugs used for neglected tropical diseases, highlighting the need for further studies in this area.
Mohr A, Segala É, Machado das Neves G, Eifler-Lima VL, Steppe M.   +4 more
europepmc   +2 more sources

Evolution of Circularly Polarized Luminescence in Atomically Precise Silver Nanoclusters with Intrinsic Chirality. [PDF]

Angew Chem Int Ed Engl
The rich excited‐state dynamics of intrinsically chiral silver nanoclusters tethering cationic species on the surface demonstrates the excited‐state dependent circularly polarized luminescence (CPL), suggesting the temporal evolution of exciton distribution.
Ishii W, Shiraogawa T, Ehara M, Sotome H, Miyasaka H, Kawai T, Nakashima T.   +6 more
europepmc   +3 more sources

Quantum Chemistry Based Simulation of Enantioseparation on Cyclodextrin- and Polysaccharide-Based Chiral Stationary Phases. [PDF]

Chemistry
We employed a systematic quantum chemistry‐based computational approach for simulating chiral HPLC, incorporating high‐level DFT methods. For the popular polysaccharide‐based CSPs, 90%$\%$ of determined elution orders were computed correctly. Abstract We assess the capability of modern quantum chemical methods to simulate enantioseparation on chiral ...
Nelles-Ziegler L, Plett C, Grimme S.
europepmc   +2 more sources

Retention time prediction for chromatographic enantioseparation by quantile geometry-enhanced graph neural network

Nature Communications, 2023
The enantioseparation of chiral molecules is a crucial and challenging task in the field of experimental chemistry, often requiring extensive trial and error with different experimental settings.
Hao Xu, Jinglong Lin, Dongxiao Zhang, Fanyang Mo   +3 more
doaj   +1 more source

Bound States in the Continuum in All‐Dielectric Metasurface: Separation of Sub‐10 nm Enantiomers

Advanced Photonics Research, 2022
Enantioseparation is crucial in pharmaceutics and agrochemicals. Compared to the current chemical technique, the optical enantioseparation is more effective means yet hampered by the weak chiral optical force. Recently, plasmonic nanostructures have been
Libang Mao, Kuan Liu, Meng Lian, Jingyuan Jia, Ying Su, Haonan Ren, Lei-Ming Zhou, Tun Cao   +7 more
doaj   +1 more source

Stationary phases based on the nanoparticles for pharmaceutical and biomolecule separations [PDF]

Nanochemistry Research, 2021
Because of impossibility to achieve a general column for separation purposes, columns must be amended in order to acquire specific chemical characteristics such as hydrophobic, hydrophilic or ionic interactions.
Forough Karami, Somayeh Karami
doaj   +1 more source

Enantioseparation of new axially chiral carboxylic acids on polysaccharide-based chiral stationary phases under normal phase elution conditions

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
In the last decade, the availability of new and versatile synthetic strategies for the preparation of substituted 4,4’-bipyridyl derivatives based on chemo- and regioselective functionalization of the 4,4’-bipyridine core has encouraged studies for ...
Barbara Sechi, Victor Mamane, Roberto Dallocchio, Alessandro Dessì, Sergio Cossu, Giorgi Jibuti, Paola Peluso   +6 more
doaj   +1 more source

Comparative Chiral Separation of Thalidomide Class of Drugs Using Polysaccharide-Type Stationary Phases with Emphasis on Elution Order and Hysteresis in Polar Organic Mode

Molecules, 2021
The enantioseparation of four phthalimide derivatives (thalidomide, pomalidomide, lenalidomide and apremilast) was investigated on five different polysaccharide-type stationary phases (Chiralpak AD, Chiralpak AS, Lux Amylose-2, Chiralcel OD and Chiralcel
Mohammadhassan Foroughbakhshfasaei, Máté Dobó, Francisc Boda, Zoltán-István Szabó, Gergő Tóth   +4 more
doaj   +1 more source

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity. [PDF]

Drug Dev Res
ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Koçak Aslan E, Lam K, Huang S, Coşkun GP, Karagüzel A, Denzinger K, Birgül K, Ülgen M, Nafie JW, Şahin O, Armstrong DW, Zamponi GW, Wolber G, Gündüz MG.   +13 more
europepmc   +2 more sources

Enantioseparation of 3-Hydroxycarboxylic Acids via Diastereomeric Salt Formation by 2-Amino-1,2-diphenylethanol (ADPE) and Cinchonidine

Molecules, 2022
Enantioseparation of 3-hydroxycarboxylic acids via diastereomeric salt formation was demonstrated using 2-amino-1,2-diphenylethanol (ADPE) and cinchonidine as the resolving agents.
Srinivas Chandrasekaran, Masaki Tambo, Yuta Yamazaki, Tatsuro Muramatsu, Yusuke Kanda, Takuji Hirose, Koichi Kodama   +6 more
doaj   +1 more source