Results 21 to 30 of about 5,412 (216)

Macrocyclic glycopeptide‐based chiral selectors for enantioseparation in sub/supercritical fluid chromatography

Analytical Science Advances, 2021
Increasing number of reported works dealing with macrocyclic glycopeptide‐based columns in sub/supercritical fluid chromatography (SFC) points to the growing interest in this area.
Denisa Folprechtová, Květa Kalíková
doaj   +1 more source

Polydopamine-Assisted Rapid One-Step Immobilization of L-Arginine in Capillary as Immobilized Chiral Ligands for Enantioseparation of Dansyl Amino Acids by Chiral Ligand Exchange Capillary Electrochromatography

Molecules, 2021
Herein, a novel L-arginine (L-Arg)-modified polydopamine (PDA)-coated capillary (PDA/L-Arg@capillary) was firstly fabricated via the basic amino-acid-induced PDA co-deposition strategy and employed to constitute a new chiral ligand exchange capillary ...
Yuanqi Gui, Baian Ji, Gaoyi Yi, Xiuju Li, Kailian Zhang, Qifeng Fu   +5 more
doaj   +1 more source

Enantioseparation of P-Stereogenic 1-Adamantyl Arylthiophosphonates and Their Stereospecific Transformation to 1-Adamantyl Aryl-H-phosphinates

Molecules, 2023
A focused library of 1-adamantyl arylthiophosphonates was prepared in racemic form. An enantioseparation method was developed for P-stereogenic thiophosphonates using (S)-1-phenylethylamine as the resolving agent. Under optimized conditions, three out of
Bence Varga, Levente Buna, Daniella Vincze, Tamás Holczbauer, Béla Mátravölgyi, Elemér Fogassy, György Keglevich, Péter Bagi   +7 more
doaj   +1 more source

Molecular Docking Observations on Enantiomeric Retention Trends and Selection of Chiral Stationary Phase. [PDF]

Chirality
Enantioseparation of chiral molecules by supercritical fluid chromatography, a combined computational and experimental approach was used to evaluate separation efficiency. Molecular docking provided insights into retention trend. ABSTRACT This study explores molecular docking as a predictive tool for enantiomeric separations in supercritical fluid ...
Dascălu AE, Ghinet A, Boulanger E, Shova S, Lipka E.   +4 more
europepmc   +2 more sources

Chiral Separation of Oxazolidinone Analogs by Capillary Electrophoresis Using Anionic Cyclodextrins as Chiral Selectors: Emphasis on Enantiomer Migration Order

Molecules, 2023
Comparative chiral separations of enantiomeric pairs of four oxazolidinone and two related thio-derivatives were performed by capillary electrophoresis, using cyclodextrins (CDs) as chiral selectors.
Zoltán-István Szabó, Francisc Boda, Béla Fiser, Máté Dobó, Levente Szőcs, Gergő Tóth   +5 more
doaj   +1 more source

A Look at the Importance of Chirality in Drug Activity: Some Significative Examples

Applied Sciences, 2022
Chirality plays an important role in the development of many pharmaceuticals, being a general property of ‘handedness’; nevertheless, a large number of pharmaceuticals are still marketed and administered as racemates.
Jessica Ceramella, Domenico Iacopetta, Angelica Franchini, Michele De Luca, Carmela Saturnino, Inmaculada Andreu, Maria Stefania Sinicropi, Alessia Catalano   +7 more
doaj   +1 more source

Photografted methacrylate-based monolithic columns coated with cellulose tris(3,5-dimethylphenylcarbamate) for chiral separation in CEC [PDF]

, 2018
A chiral capillary monolithic column for enantiomer separation in capillary electrochromatography was prepared by coating cellulose tris(3,5-dimethylphenylcarbamate) on porous glycidyl methacrylate-co-ethylene dimethacrylate monolith in capillary format ...
Al-Othman, Carrasco-Correa, Carrasco-Correa, Carrasco-Correa, Castells, Chankvetadze, Chankvetadze, Chen, Connolly, Connolly, Currivan, Dixit, Dong, Eeltink, Fanali, Fanali, Girod, Guerrouache, He, Hernández-Borges, Hilder, Huang, Hödl, Ling, Lv, Lämmerhofer, Meyring, Ou, Peters, Peters, Preinerstorfer, Preinerstorfer, Pucci, Qin, Qin, Rohr, Schmid, Stachowiak, Stachowiak, Tian, Vonk, Wu, Zheng   +42 more
core   +1 more source

Enantioselective Monitoring of Biodegradation of Ketamine and Its Metabolite Norketamine by Liquid Chromatography

Chemosensors, 2021
Ketamine (K) and its main metabolite, norketamine (NK), are chiral compounds that have been found in effluents from wastewater treatment plants (WWTPs) and aquatic environments.
Ariana Pérez-Pereira, Alexandra Maia, Virgínia Gonçalves, Cláudia Ribeiro, Maria Elizabeth Tiritan   +4 more
doaj   +1 more source

A Design of Experiments-Based Chiral HPLC Method for the Quantification of Talazoparib and Enantiomeric Purity Determination in Pharmaceutical Formulations. [PDF]

Chirality
A design of experiments–based chiral HPLC method was developed for the enantiomeric separation and quantification of talazoparib in pharmaceutical formulations. Efficient resolution of the enantiomers (RS > 7) was achieved within 12 min. The method was validated and successfully applied to tablet analysis, and its environmental sustainability was ...
Atila Karaca S, Aliyeva S, Yeniceli D.
europepmc   +2 more sources

Use of capillary electrophoresis as a method development tool for classical gel electrophoresis [PDF]

, 1998
Capillary electrophoresis (CE) was used to optimize the buffer pH, ionic strength and sulfated cyclodextrin concentrations for enantiomeric separation of piperoxan.
Gratz, Samuel R., Stalcup, Apryll, Sutton, Richard M. C.   +2 more
core   +1 more source