Results 41 to 50 of about 48,679 (293)

AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volunteers

Acta Pharmaceutica, 2019
The relative contribution of CYP2C9 allelic variants to the pharmacokinetics (PK) of ibuprofen (IBP) enantiomers has been studied extensively, but the potential clinical benefit of pharmacogenetically guided IBP treatment is not evident yet.
Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar   +7 more
doaj   +1 more source

Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Molecules, 2017
Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers.
Kristyna Krasulova, Ondrej Holas, Pavel Anzenbacher   +2 more
doaj   +1 more source

A Direct Analysis of β-N-methylamino-l-alanine Enantiomers and Isomers and Its Application to Cyanobacteria and Marine Mollusks

Toxins, 2023
Of the wide variety of toxic compounds produced by cyanobacteria, the neurotoxic amino acid β-N-methylamino-l-alanine (BMAA) has attracted attention as a result of its association with chronic human neurodegenerative diseases such as ALS and Alzheimer’s.
James S. Metcalf, Sandra Anne Banack, Peter B. Wyatt, Peter B. Nunn, Paul A. Cox   +4 more
doaj   +1 more source

Chiral inversion of 2-arylpropionoic acid (2-APA) enantiomers during simulated biological wastewater treatment

, 2022
This study examined the removal and enantio‑specific fate of a suite of eleven chiral 2-arylpropionic acids (2-APAs) during biological wastewater treatment simulated in a laboratory-scale membrane bioreactor (MBR). Using pure (R)- and (S)- enantiomers in
Nguyen, Luong N, McDonald, James A, Neale, Peta A, Nguyen, Anh Q, Leusch, Frederic DL, Khan, Stuart J, Nghiem, Long D   +6 more
core   +1 more source

Diastereoisomer-Specific Biotransformation of Hexabromocyclododecanes by a Mixed Culture Containing Dehalococcoides mccartyi Strain 195

Frontiers in Microbiology, 2018
Hexabromocyclododecane (HBCD) stereoisomers may exhibit substantial differences in physicochemical, biological, and toxicological properties. However, there remains a lack of knowledge about stereoisomer-specific toxicity, metabolism, and environmental ...
Yin Zhong, Heli Wang, Heli Wang, Zhiqiang Yu, Xinhua Geng, Chengyu Chen, Dan Li, Dan Li, Xifen Zhu, Xifen Zhu, Huajun Zhen, Weilin Huang, Donna E. Fennell, Lily Y. Young, Ping’an Peng, Ping’an Peng   +15 more
doaj   +1 more source

Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration

Frontiers in Pharmacology, 2023
Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. vivax radical cure and prevention of malaria transmission. PQ is a racemic drug and
Washim Khan, Yan-Hong Wang, Narayan D. Chaurasiya, N. P. Dhammika Nanayakkara, H. M. Bandara Herath, Kerri A. Harrison, Gray Dale, Donald A. Stanford, Eric P. Dahl, James D. McChesney, Waseem Gul, Mahmoud A. ElSohly, Mahmoud A. ElSohly, Mahmoud A. ElSohly, David Jollow, Babu L. Tekwani, Larry A. Walker   +16 more
doaj   +1 more source

Cytotoxicity of enantiomers of gossypol [PDF]

British Journal of Cancer, 1986
The effect of gossypol on cell proliferation was studied using 24-well multiwell dishes. Cells were added to each well and incubated for 24 hours before the addition of different concentration of gossypol which was dissolved in dimethyl sulfoxide immediately prior to use.
A E, Joseph, S A, Matlin, P, Knox
openaire   +2 more sources

Review: Escitalopram—translating molecular properties into clinical benefit: reviewing the evidence in major depression [PDF]

, 2010
The majority of currently marketed drugs contain a mixture of enantiomers; however, recent evidence suggests that individual enantiomers can have pharmacological properties that differ importantly from enantiomer mixtures.
Taylor, David, Leonard, Brian, Taylor, David; id_orcid   +2 more
core   +1 more source

Enantiomeric separation of four pairs of alkaloids by using a C18 column tandem polysaccharide-based chiral column

Reviews in Analytical Chemistry
Alkaloid enantiomers have different physiological and pharmacological effects, and different chiral compositions have a large impact on cigarette sensory and use safety.
Si Xiaoxi, Tian Yu, Xu Shufang, Liu Chunbo, Li Zhenjie, Yang Ji, Guan Ying, Xie Yangzhou, Shi Xiaoqing, Xu Zhigang, Liu Zhihua   +10 more
doaj   +1 more source

Chemical Composition and Biological Activities of Essential Oils from Origanum vulgare Genotypes Belonging to the Carvacrol and Thymol Chemotypes

Plants, 2023
The remarkable biological activities of oregano essential oils (EOs) have recently prompted a host of studies aimed at exploring their potential innovative applications in the food and pharmaceutical industries.
Paola Zinno, Barbara Guantario, Gabriele Lombardi, Giulia Ranaldi, Alberto Finamore, Sofia Allegra, Michele Massimo Mammano, Giancarlo Fascella, Antonio Raffo, Marianna Roselli   +9 more
doaj   +1 more source