Results 41 to 50 of about 48,807 (291)
Pharmaceuticals, 2022 Pentedrone and methylone can express stereoselectivity in toxicokinetic and toxicodynamic processes. Similarly, their chiral discrimination in metabolism, which was not yet evaluated, can result in different metabolic profiles and subsequent hepatotoxic ...
Bárbara Silva +7 more
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, 2014 Citation: 'enantiomer' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.E02069 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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Metabolic profiling of praziquantel enantiomers [PDF]
, 2014 Praziquantel (PZQ), prescribed as a racemic mixture, is the most readily available drug to treat schistosomiasis. In the present study, ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass ...
Idle, Jeffrey +9 more
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Cytotoxicity of enantiomers of gossypol [PDF]
British Journal of Cancer, 1986 The effect of gossypol on cell proliferation was studied using 24-well multiwell dishes. Cells were added to each well and incubated for 24 hours before the addition of different concentration of gossypol which was dissolved in dimethyl sulfoxide immediately prior to use.
A E, Joseph, S A, Matlin, P, Knox
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Review: Escitalopram—translating molecular properties into clinical benefit: reviewing the evidence in major depression [PDF]
, 2010 The majority of currently marketed drugs contain a mixture of enantiomers; however, recent evidence suggests that individual enantiomers can have pharmacological properties that differ importantly from enantiomer mixtures.
Taylor, David +2 more
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Reviews in Analytical ChemistryAlkaloid enantiomers have different physiological and pharmacological effects, and different chiral compositions have a large impact on cigarette sensory and use safety.
Si Xiaoxi +10 more
doaj +1 more source
Simultaneous Resolution of Clenbuterol Hydrochloride Enantiomers and Propranolol Hydrochloride Enantiomers using Thin-Layer Chromatography [PDF]
, 2011 Resolution of clenbuterol hydrochloride enantiomers and propranolol hydrochloride enantiomers was achieved by thin-layer chromatography using methyl-β-cyclodextrin impregnated silica gel GF254 plates.
Du Shu Huang, Jin Gang Yu
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Ketamine: A tale of two enantiomers [PDF]
Journal of Psychopharmacology, 2020 The discovery of the rapid antidepressant effects of the dissociative anaesthetic ketamine, an uncompetitive N-Methyl-D-Aspartate receptor antagonist, is arguably the most important breakthrough in depression research in the last 50 years. Ketamine remains an off-label treatment for treatment-resistant depression with factors that limit widespread use ...
Luke A Jelen +2 more
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Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells [PDF]
, 1994 A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring ...
Wiegrebe, Wolfgang +4 more
core +1 more source