Results 61 to 70 of about 55,056 (232)
Matrix‐Activated Aptamer Sensors for Human Serum Analysis
Angewandte Chemie, EarlyView.The sample self‐analyzes: The predominant serum proteins, albumin and immunoglobulin G, were leveraged to activate the response of fluorescent aptamer probes within the biological matrix. The fluorescence‐anisotropy‐based sensing platform demonstrated both performance and consistency for the direct detection of small molecules in serum‐rich samples ...
Amandine Barbaroux +8 more
wiley +2 more sources
Molecules, 2016 The research into the separation of drug enantiomers is closely related to the safety and efficiency of the drugs. The aim of this study was to develop a simple and validated HPLC method to analyze cetirizine enantiomers.
Aleksandra Chmielewska +2 more
doaj +1 more source
Metabolic profiling of praziquantel enantiomers [PDF]
, 2014 Praziquantel (PZQ), prescribed as a racemic mixture, is the most readily available drug to treat schistosomiasis. In the present study, ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass ...
Idle, Jeffrey +9 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu +10 more
wiley +1 more source
Chiral Fjord‐Edged Nanographenes Constructed by Allylic‐Migration‐Mediated Cyclization
Angewandte Chemie, EarlyView.A novel allylic‐migration‐mediated cyclization strategy enables the construction of two fjord‐edged nanographenes without steric blocking groups. The resulting non‐planar molecules exhibit remarkable chiroptical properties, with an absorption dissymmetry factor surpassing those of pristine [5]helicene and previously reported fjord‐edged nanographenes ...
Zhen‐Lin Qiu +7 more
wiley +2 more sources
Review: Escitalopram—translating molecular properties into clinical benefit: reviewing the evidence in major depression [PDF]
, 2010 The majority of currently marketed drugs contain a mixture of enantiomers; however, recent evidence suggests that individual enantiomers can have pharmacological properties that differ importantly from enantiomer mixtures.
Taylor, David +2 more
core +1 more source
Advanced Intelligent Discovery, EarlyView.Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang +9 more
wiley +1 more source
PharmaceuticalsBackground/Objectives: Diseases associated with inflammatory processes continue to grow steadily throughout the world. Unfortunately, prolonged use of drugs induces adverse effects ranging from hypersensitivity reactions to damage to the digestive system.
Salud Pérez-Gutiérrez +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.Linear aromatic oligomers display intense photoluminescence (PL), circular dichroism (CD), and circularly polarized luminescence (CPL) properties upon non‐covalent encapsulation by axially‐chiral aromatic capsules under ambient aqueous conditions.
Yoshihisa Hashimoto +4 more
wiley +2 more sources
Light‐Driven Out‐of‐Equilibrium Helicity Control in a Diarylethene–Helicene Photosystem
Angewandte Chemie, EarlyView.Distinct energy landscapes of different helicities in the open and closed states of a diarylethene–helicene photoswitch enable a light‐driven energy ratchet. Helix inversion occurs selectively in the closed form, and the resulting helicity is transferred and kinetically trapped upon ring opening, generating a persistent out‐of‐equilibrium chiral state ...
Eric Sidler +3 more
wiley +2 more sources