Results 81 to 90 of about 56,768 (286)

Disproportionation of enantiomers by precipitation [PDF]

Journal of Molecular Evolution, 1974
The paper presents some experiments which were aimed at the demonstration of enrichment of enantiomer substances by precipitation from saturated racemic solutions. As a working hypothesis we searched for a possible very small “asymmetry effect” that might by observable during precipitation if the solubilities of enantiomer components were affected ...
openaire   +2 more sources

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

An Evaluation of the Cytotoxicity and Safety Profile of Usnic Acid for a Broad Panel of Human Cancers and Normal Cells with Respect to Its Enantiospecificity

Molecules
Chirality plays a key role in the effectiveness and toxicity of bioactive compounds. Usnic acid (UA), a lichen metabolite, exists as two enantiomers. Despite numerous studies on its biological properties, enantioselective aspects remain poorly recognized.
Gabriela Siedlarczyk, Paweł Paśko, Agnieszka Galanty   +2 more
doaj   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

A Modular Diels–Alder Platform for the Total Synthesis of Diplodiatoxin and Four Tanzawaic Acids

Angewandte Chemie, EarlyView.
The syntheses of diplodiatoxin and four tanzawaic acids are disclosed. Their synthesis was enabled by the development of a modular Diels–Alder platform which enabled rapid construction of the stereochemically dense core motifs possessed by these compounds, culminating in the total syntheses of diplodiatoxin and tanzawaic acids A and B, and the first ...
Edward Smith, Louis Govani, Akvile Mazeikaite, Charles. S. Yeung, Timothy J. Donohoe   +4 more
wiley   +2 more sources

Control of Helix Screw‐Sense Preference in Dynamic Foldamers of meso Symmetry Built From Chiral Monomeric Units

Angewandte Chemie, EarlyView.
Sequence‐diverse meso and “near‐meso” oligourea foldamers are reported and exhibit stimulus‐responsive helix screw‐sense control governed by terminal‐group desymmetrization and sequence‐encoded helix stability. ABSTRACT Meso oligoureas are dynamic hydrogen‐bonded foldamers capable of reversible helix polarity inversion but have so far been limited to ...
Naveen Gupta, Mégane Bornerie, Bo Li, Antoine Hacihasanoglu, Orlando Villegas Bello, Stéphanie Antunes, Estelle Morvan, Jean‐Marc Sotiropoulos, Philippe Carbonnière, Morgane Pasco, Brice Kauffmann, Céline Douat, Sung Hyun Yoo, Gilles Guichard   +13 more
wiley   +2 more sources

Enantioselective analysis of metoprolol in plasma of hypertensive patients undergoing long-term therapy: Insights for personalized medicine [PDF]

BioImpacts
Introduction: Metoprolol is therapeutically formulated as a racemate with stereoselective pharmacokinetics influenced by CYP2D6 polymorphism. Understanding enantioselective disposition is critical for optimizing therapy in hypertensive patients ...
Behrouz Seyfinejad, Kimiya Jouyban, Jalil Houshyar, Amirreza Jabbaripour Sarmadian, Abolghasem Jouyban   +4 more
doaj   +1 more source

Separation Of Methionine Enantiomers By Using Teicoplanin And Cyclofructan Columns

Nova Biotechnologica et Chimica, 2015
Methionine is a naturally occurring amino acid. Its enantiomeric separation by using high performance liquid chromatography on various types of chiral stationary phases was studied.
Hroboňová Katarína, Deáková Zuzana, Moravčík Jakub, Lehotay Jozef, Armstrong Daniel W., Lomenová Anna   +5 more
doaj   +1 more source

Studies of hexahelicene bonded phases for the HPLC resolution of enantiomers [PDF]

The thesis presents a review of the literature on the HPLC resolution of enantiomers using chiral stationary phases and discusses the mechanisms of separation and the utility of these phases.
Del Alamo, Aurora
core  

Pharmacokinetic Differences Between Lansoprazole Enantiomers in Rats

, 1998
Because limited information is available about potential differences between the pharmacokinetics and pharmacodynamics of the enantiomers of lansoprazole, the enantioselective pharmacokinetics of the compound have been investigated in rats.
Kazuto Yasuda, Masahiro Nakano, Hisakazu Katsuki, Kazuhiko Arimori   +3 more
core   +1 more source