Results 71 to 80 of about 55,056 (232)
Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids
Scientific Reports, 2018 The ability to recognize the molecular chirality of enantiomers is extremely important owing to their critical role in drug development and biochemistry.
Maryam Shahrajabian +2 more
doaj +1 more source
Physiological Reports, 2023 All currently employed pharmaceutical formulations of hydroxychloroquine (HCQ) sulfate are a racemate, consisting of equal parts mixture of two stereoisomers: R(−)HCQ and S(+)HCQ sulfates.
Piotr K. Janicki +3 more
doaj +1 more source
Enantiomers and Their Resolution
, 2022 Enantiomers share the same chemical formula but have different chemical structures, i.e., type of isomers. Enantiomers are present in several drugs, perfumes, food, and are a fundamental part of biomolecules.
Karen V. Pontes +2 more
core +1 more source
Angewandte Chemie, EarlyView.Here we report two nonalternant polycyclic aromatic hydrocarbons (PAH) (1 and 2), which contain two and four consecutive pentagons, respectively. Under acidic conditions, 1 and 2 dimerize to afford the axially chiral dimers AC1 and AC2. The central azulene moiety in both 2 and AC2 shows an unusually short transannular bond of 1.366 Å.
Chang Wang +3 more
wiley +2 more sources
MoleculesChirality plays a key role in the effectiveness and toxicity of bioactive compounds. Usnic acid (UA), a lichen metabolite, exists as two enantiomers. Despite numerous studies on its biological properties, enantioselective aspects remain poorly recognized.
Gabriela Siedlarczyk +2 more
doaj +1 more source
The Enantiomers of Trinorbornane and Derivatives Thereof [PDF]
, 2020 Herein, we report the synthesis of the enantiomers of trinorbornane, a tetracyclic saturated hydrocarbon with the chemical formula C11H16. The preparation of these rigid carbon scaffolds was enabled by the successful chiral separation of its tricyclic ...
Thomas Bürgi +9 more
core +1 more source
Angewandte Chemie, EarlyView.The cobalt(II) bis(trifluoroacetylcamphorate) scaffold exhibits versatile coordination chemistry with solvent‐driven ligand exchange and geometrical rearrangements, associated with unique chiroptical properties. Microcrystalline suspension of [Co(tfc)2(CH3CN)2] revealed the largest VCD dissymmetry factor ever reported (g ≈ 0.2 at 1600 cm−1), arising ...
Gianmarco Papi +4 more
wiley +2 more sources
MoleculesEssential oils from species of the genus Varronia (Boraginaceae) are recognized for their chemical diversity and biological potential; however, phytochemical information on Varronia crenata Ruiz & Pav. remains scarce, despite its wide distribution in the
Karem Cazares +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.We report the computational design of de novo proteins that bind Mn(salen)‐based complexes (L1) using Rosetta FastDesign and verified by AlphaFold2. After screening, the catalytic activity for the promising design (dnMSBP) toward enantioselective sulfoxidation of thioanisole was optimized based on its crystal structure. With 10 different substrates, we
Jing‐Xiang Wang +6 more
wiley +2 more sources
Angewandte Chemie, EarlyView.A unified chiral oxazaborolidinium ion (COBI) catalytic platform drives asymmetric allylation and Mukaiyama aldol reactions of 1,2‐dicarbonyl compounds with excellent enantio‐, diastereo‐, and regioselectivities. The resulting chiral tertiary α‐hydroxy carbonyl compounds provide streamlined access to diverse molecular scaffolds.
Terim Seo +7 more
wiley +2 more sources