Results 71 to 80 of about 56,768 (286)
PharmaceuticalsBackground/Objectives: Diseases associated with inflammatory processes continue to grow steadily throughout the world. Unfortunately, prolonged use of drugs induces adverse effects ranging from hypersensitivity reactions to damage to the digestive system.
Salud Pérez-Gutiérrez +5 more
doaj +1 more source
Advanced Science, EarlyView.The C3‐symmetric conjugate TASe, which integrates benzoselenadiazole, alanine, and acylhydrazone modules, self‐assembles into a chalcogen‐/hydrogen‐bonded porous framework in the solid state and uniform chiral nanospheres in aqueous media. These assemblies protect cardiomyocytes from doxorubicin‐induced oxidative injury by scavenging intracellular ...
Jinkui Teng +11 more
wiley +1 more source
Light‐Driven Out‐of‐Equilibrium Helicity Control in a Diarylethene–Helicene Photosystem
Angewandte Chemie, EarlyView.Distinct energy landscapes of different helicities in the open and closed states of a diarylethene–helicene photoswitch enable a light‐driven energy ratchet. Helix inversion occurs selectively in the closed form, and the resulting helicity is transferred and kinetically trapped upon ring opening, generating a persistent out‐of‐equilibrium chiral state ...
Eric Sidler +3 more
wiley +2 more sources
MoleculesEssential oils from species of the genus Varronia (Boraginaceae) are recognized for their chemical diversity and biological potential; however, phytochemical information on Varronia crenata Ruiz & Pav. remains scarce, despite its wide distribution in the
Karem Cazares +4 more
doaj +1 more source
qcGEM: A Graph‐Based Molecular Representation With Quantum Chemistry Awareness
Advanced Science, EarlyView.In this work, we introduce qcGEM, a quantum‐chemistry‐aware graph‐based embedding of molecules that incorporates physical priors into molecular representation learning. Through a specially designed model architecture to adequately process quantum chemistry information as well as three‐dimensional molecular geometry, qcGEM provides a compact, physics ...
Haoyu Wang +3 more
wiley +1 more source
Angewandte Chemie, EarlyView.Here we report two nonalternant polycyclic aromatic hydrocarbons (PAH) (1 and 2), which contain two and four consecutive pentagons, respectively. Under acidic conditions, 1 and 2 dimerize to afford the axially chiral dimers AC1 and AC2. The central azulene moiety in both 2 and AC2 shows an unusually short transannular bond of 1.366 Å.
Chang Wang +3 more
wiley +2 more sources
Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids
Scientific Reports, 2018 The ability to recognize the molecular chirality of enantiomers is extremely important owing to their critical role in drug development and biochemistry.
Maryam Shahrajabian +2 more
doaj +1 more source
Physiological Reports, 2023 All currently employed pharmaceutical formulations of hydroxychloroquine (HCQ) sulfate are a racemate, consisting of equal parts mixture of two stereoisomers: R(−)HCQ and S(+)HCQ sulfates.
Piotr K. Janicki +3 more
doaj +1 more source
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley +1 more source
To Greater Twist: A Kinetically Biased π‐Radical Cascade
Angewandte Chemie, EarlyView.π‐Radical cascades enable step‐economic construction of complex polycyclic aromatic frameworks. In this work, we show that a multifurcating pathway can be kinetically steered toward a single, more distorted product. This counterintuitive “falling‐upward” outcome arises from an intrinsic mechanistic bias, revealing a broader dimension of control in π ...
Yong Yang +8 more
wiley +2 more sources