Diastereoselective Spiroannulation of Phenolic Substrates: Advances Towards the Asymmetric Formation of the Manumycin m-C7N Core Skeleton [PDF]
Molecules, 2007 The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new ...
Guy L Plourde, Plourde Guy L
exaly +5 more sources
Eco-friendly K‑10 Clay-Mediated [3 + 3] Spiroannulation of Morita–Baylis–Hillman Adduct of Isatin with Anthracene: Synthesis of Green Fluorophore Compounds [PDF]
ACS Omega, 2023 An easy and simple spiroannulation of the Morita–Baylis–Hillman adduct of isatin derivatives with anthracene was achieved in moderate-to-good yields (37–75%). The spiroderivatives synthesized in this work exhibited green fluorescence properties.
Vadivel Vaithiyanathan +1 more
doaj +3 more sources
Electrooxidative palladium- and enantioselective rhodium-catalyzed [3 + 2] spiroannulations. [PDF]
Chem Sci, 2022 Despite indisputable progress in the development of electrochemical transformations, electrocatalytic annulations for the synthesis of biologically relevant three-dimensional spirocyclic compounds has as of yet not been accomplished.
Wei W, Scheremetjew A, Ackermann L.
europepmc +5 more sources
Catalytic asymmetric synthesis of (N, N)- spiroketal via Pd-catalyzed enantioconvergent aminocarbonylation and dearomative nucleophilic aza-addition [PDF]
Nature CommunicationsChiral spirocyclic skeletons have found widespread applications in asymmetric catalysis, drug discovery, and functional materials due to their rigid three-dimensional architecture and excellent stereochemical stability.
Lei Su, Shen Gao, Jiawang Liu
doaj +2 more sources
Isoindolinone Synthesis via One-Pot Type Transition Metal Catalyzed C-C Bond Forming Reactions. [PDF]
Chemistry, 2021 Isoindolinone motif can found in a large variety biologically and pharmaceutically active compounds. Due to the central role in a number of applications, the synthetic methodologies for accessing this heterocyclic skeleton have received significant attention during the past decade.
Savela R, Méndez-Gálvez C.
europepmc +2 more sources
Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed C-H Functionalization and Spiroannulation. [PDF]
Angew Chem Int Ed Engl, 2015 Chirale Cp‐Rhodium‐Komplexe vermitteln die enantioselektive Enol‐dirigierte C(sp2)‐H‐Funktionalisierung und oxidative Anellierung mit Alkinen unter Bildung von Spiroindenen mit quartären Kohlenstoff‐Stereozentren. Entscheidend für hohe ee‐Werte sind offenbar eine hohe Selektivität zwischen zwei dirigierenden Gruppen sowie die Kontrolle der ...
Reddy Chidipudi S +3 more
europepmc +2 more sources
Diastereoselective Spiroannulation of Phenolic Substrates: Synthesis of (±)-2-tert-Butyl-6-methoxy-1-oxaspiro[4,5]deca-6,9-diene-8-one [PDF]
Molecules, 2005 The synthesis of a new spiroether is described. The title compound is obtained as a diastereomeric mixture in 45% yield.
N. English, G. Plourde
doaj +2 more sources
Base-Regulated Spiroannulation: Insights into the Palladium-Catalyzed [2 + 2 + 1] Annulation of 1,2-Dihaloarenes, Alkynes, and 2‑Naphthol [PDF]
ACS OmegaJin-Feng Zhong +7 more
doaj +2 more sources
Green Synthesis and Catalysis, 2023 Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds.
Wei-Yi Pu, Xin-Yi Chen, Lin Dong
doaj +1 more source
Reductive Spiroannulation of Nitriles with Secondary Electrophiles [PDF]
Organic Letters, 2005 AbstractFor Abstract see ChemInform Abstract in Full Text.
Matthew D, Morin, Scott D, Rychnovsky
openaire +2 more sources