Diastereoselective Spiroannulation of Phenolic Substrates: Advances Towards the Asymmetric Formation of the Manumycin m-C7N Core Skeleton [PDF]
Molecules, 2007 The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new ...
Guy L Plourde
exaly +5 more sources
Eco-friendly K‑10 Clay-Mediated [3 + 3] Spiroannulation of Morita–Baylis–Hillman Adduct of Isatin with Anthracene: Synthesis of Green Fluorophore Compounds [PDF]
ACS Omega, 2023 An easy and simple spiroannulation of the Morita–Baylis–Hillman adduct of isatin derivatives with anthracene was achieved in moderate-to-good yields (37–75%). The spiroderivatives synthesized in this work exhibited green fluorescence properties.
Vadivel Vaithiyanathan +1 more
doaj +3 more sources
Electrooxidative palladium- and enantioselective rhodium-catalyzed [3 + 2] spiroannulations. [PDF]
Chem Sci, 2022 Despite indisputable progress in the development of electrochemical transformations, electrocatalytic annulations for the synthesis of biologically relevant three-dimensional spirocyclic compounds has as of yet not been accomplished.
Wei W, Scheremetjew A, Ackermann L.
europepmc +5 more sources
Catalytic asymmetric synthesis of (N, N)- spiroketal via Pd-catalyzed enantioconvergent aminocarbonylation and dearomative nucleophilic aza-addition [PDF]
Nature CommunicationsChiral spirocyclic skeletons have found widespread applications in asymmetric catalysis, drug discovery, and functional materials due to their rigid three-dimensional architecture and excellent stereochemical stability.
Lei Su, Shen Gao, Jiawang Liu
doaj +2 more sources
Base-Regulated Spiroannulation: Insights into the Palladium-Catalyzed [2 + 2 + 1] Annulation of 1,2-Dihaloarenes, Alkynes, and 2‑Naphthol [PDF]
ACS OmegaJin-Feng Zhong +7 more
doaj +2 more sources
Green Synthesis and Catalysis, 2023 Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds.
Wei-Yi Pu, Xin-Yi Chen, Lin Dong
doaj +1 more source
Reductive Spiroannulation of Nitriles with Secondary Electrophiles [PDF]
Organic Letters, 2005 AbstractFor Abstract see ChemInform Abstract in Full Text.
Matthew D, Morin, Scott D, Rychnovsky
openaire +2 more sources
Synthesis of N-(2,8-Dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yl) Acetamide and Benzamide
Molbank, 2009 The syntheses of two new spirolactones are described. Each compound was obtained as an off-white solid in 66% yields from 4-hydroxy-3-nitrobenzaldehyde.
Guy L. Plourde, Randy R. Spaetzel
doaj +1 more source
Molecules, 2008 The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been madeaccessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclicbenzofuranones 2 and 3, respectively.
Gunter Fischer +4 more
doaj +1 more source
Molecules, 2005 The synthesis of a new spiroether is described. The title compound is obtained as a diastereomeric mixture in 45% yield.
N. English, G. Plourde
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