Electrooxidative palladium- and enantioselective rhodium-catalyzed [3 + 2] spiroannulations. [PDF]
Chem Sci, 2022 Despite indisputable progress in the development of electrochemical transformations, electrocatalytic annulations for the synthesis of biologically relevant three-dimensional spirocyclic compounds has as of yet not been accomplished.
Wei W, Scheremetjew A, Ackermann L.
europepmc +6 more sources
Eco-friendly K‑10 Clay-Mediated [3 + 3] Spiroannulation of Morita–Baylis–Hillman Adduct of Isatin with Anthracene: Synthesis of Green Fluorophore Compounds [PDF]
ACS Omega, 2023 Vadivel Vaithiyanathan +1 more
doaj +3 more sources
Diastereoselective Spiroannulation of Phenolic Substrates: Advances Towards the Asymmetric Formation of the Manumycin m-C7N Core Skeleton [PDF]
Molecules, 2007 The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new ...
Thomas W. Scully +3 more
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Diastereoselective Spiroannulation of Phenolic Substrates: Synthesis of (±)-2-tert-Butyl-6-methoxy-1-oxaspiro[4,5]deca-6,9-diene-8-one [PDF]
Molecules, 2005 The synthesis of a new spiroether is described. The title compound is obtained as a diastereomeric mixture in 45% yield.
N. English, G. Plourde
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Base-Regulated Spiroannulation: Insights into the Palladium-Catalyzed [2 + 2 + 1] Annulation of 1,2-Dihaloarenes, Alkynes, and 2‑Naphthol [PDF]
ACS OmegaJin-Feng Zhong +7 more
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Rhodium-Catalyzed Enantioselective Spiroannulation of 2-Alkenylphenols with Alkynes [PDF]
Chinese Journal of Organic Chemistry, 2023 Shuli You +4 more
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Reductive Spiroannulation of Nitriles with Secondary Electrophiles [PDF]
Organic Letters, 2005 AbstractFor Abstract see ChemInform Abstract in Full Text.
Matthew D, Morin, Scott D, Rychnovsky
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Catalytic asymmetric synthesis of (N, N)- spiroketal via Pd-catalyzed enantioconvergent aminocarbonylation and dearomative nucleophilic aza-addition [PDF]
Nature CommunicationsChiral spirocyclic skeletons have found widespread applications in asymmetric catalysis, drug discovery, and functional materials due to their rigid three-dimensional architecture and excellent stereochemical stability.
Lei Su, Shen Gao, Jiawang Liu
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Dearomatizing Spiroannulation Reagents: Direct Access to Spirocycles from Indoles and Dihalides [PDF]
Organic Letters, 2018 Unfunctionalized indoles can be directly converted into 3,3'-spirocyclic indolenines and indolines upon reaction with electrophilic dihalides in the presence of t-BuOK/BEt3. This double C-C bond forming reaction, which simultaneously generates a quaternary spirocyclic center, typically proceeds in high yield and has good functional group tolerance.
Liddon, John T R +3 more
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Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols. [PDF]
Chem Sci, 2020 Tan B +6 more
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