Results 11 to 20 of about 490 (165)

K-10 Clay-Promoted Oxidative [3+3] Spiroannulation of Bromo-Isomerized MBH Isatin Adducts with Anthracene: A Versatile Route to Green, Orange Fluorophores and Domino Hydrogen Harvesting Method

SynOpen
Green-emissive spirooxindole fluorophores were efficiently synthesized through a K-10 clay-mediated [3+3] spiroannulation of bromine-isomerized Morita–Baylis–Hillman (MBH) adducts of isatin derivatives with anthracene.
Selvaraj Aruljothi, Thirunavukkarasu Maheswary, Vadivel Vaithiyanathan   +2 more
doaj   +2 more sources

Electrophilic aryl spiroannulation induced by diaryliodonium salts: efficient synthesis of [5,5]-spiro lactone-lactam scaffolds from α-cyanocarboxylates

Green Synthesis and Catalysis
Spirocyclic architectures represent one of the privileged three-dimensional scaffolds in pharmaceutical chemistry and drug discovery, while the new-skeletal synthesis of spiromolecules from simple starting materials remains a challenging task.
Zhiyuan Bao, Yifei Li, Ruitong Zhang, Zhengsen Yu, Chao Chen   +4 more
doaj   +2 more sources

Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides

Green Synthesis and Catalysis, 2023
Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds.
Wei-Yi Pu, Xin-Yi Chen, Lin Dong
doaj   +1 more source

Reductive Spiroannulation of Nitriles with Secondary Electrophiles [PDF]

Organic Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Matthew D, Morin, Scott D, Rychnovsky
openaire   +2 more sources

Ruthenium‐Catalyzed Decarboxylative Rearrangement of 4‐Alkenyl‐isoxazol‐5‐ones to Pyrrole Derivatives

European Journal of Organic Chemistry, Volume 2022, Issue 25, July 7, 2022., 2022
Easily accessible isoxazol‐5(4H)‐ones are useful precursors of different heterocycles. In this work, the ruthenium‐catalyzed transformation of 4‐alkenyl‐substituted isoxazol‐5‐ones to 1H‐pyrrole derivatives is reported. Abstract Easily accessible isoxazol‐5(4H)‐ones are useful precursors of heterocycles.
Letizia Molteni, Camilla Loro, Michael S. Christodoulou, Marta Papis, Francesca Foschi, Egle M. Beccalli, Gianluigi Broggini   +6 more
wiley   +1 more source

Synthesis of N-(2,8-Dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yl) Acetamide and Benzamide

Molbank, 2009
The syntheses of two new spirolactones are described. Each compound was obtained as an off-white solid in 66% yields from 4-hydroxy-3-nitrobenzaldehyde.
Guy L. Plourde, Randy R. Spaetzel
doaj   +1 more source

Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1

Molecules, 2008
The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been madeaccessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclicbenzofuranones 2 and 3, respectively.
Gunter Fischer, Birte Hernandez Alvarez, Boris Féaux de Lacroix, Anahita Hessamian-Alinejad, Manfred Braun   +4 more
doaj   +1 more source

Synthesis of 6-Methoxy-1-oxaspiro[4,5]deca-6,9-diene-8-one

Molecules, 2002
The synthesis of a new spirolactone is described. The title compound is obtained as a white solid in 46% yield from 3-(4-hydroxy-2-methoxyphenyl)propanoic acid using [Bis(trifluoroacetoxy)iodo]benzene (PIFA) as the oxidant.
Benjamin B. Fisher, Guy L. Plourde
doaj   +1 more source

Dearomatizing Spiroannulation Reagents: Direct Access to Spirocycles from Indoles and Dihalides [PDF]

Organic Letters, 2018
Unfunctionalized indoles can be directly converted into 3,3'-spirocyclic indolenines and indolines upon reaction with electrophilic dihalides in the presence of t-BuOK/BEt3. This double C-C bond forming reaction, which simultaneously generates a quaternary spirocyclic center, typically proceeds in high yield and has good functional group tolerance.
Liddon, John T R, Rossi-Ashton, James A, Taylor, Richard J K, Unsworth, William P   +3 more
openaire   +4 more sources

Strategies Toward Accessing Enantioenriched (Hetero)Benzo‐Fused 5‐ and 6‐ Membered Rings via Intermolecular Carbometalation

Angewandte Chemie International Edition, Volume 65, Issue 23, 1 June 2026.
The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans, Armaan Grewal, Xavier Abel‐Snape, Mark Lautens   +3 more
wiley   +1 more source