Results 11 to 20 of about 360 (157)
Stereoselective N‐Heterocyclic‐Carbene‐Catalyzed Spiroannulation as an Access Towards Spirobenzofuranone‐Fused Cyclohexenones [PDF]
Advanced Synthesis &Catalysis, Volume 366, Issue 24, Page 5008-5014, December 17, 2024.Abstract In this work, we present an organocatalytic spiroannulation method that provides access to spirocyclic benzofuran‐2‐ones. The reaction proceeds via the generation of an azolium dienolate from an α‐bromo‐α,β‐unsaturated aldehyde using a chiral N‐heterocyclic carbene, followed by annulation with benzofuran‐2‐one‐derived alkenes.
Ladislav Lóška +8 more
wiley +3 more sources
Isoindolinone Synthesis via One-Pot Type Transition Metal Catalyzed C-C Bond Forming Reactions. [PDF]
Chemistry, 2021 Isoindolinone motif can found in a large variety biologically and pharmaceutically active compounds. Due to the central role in a number of applications, the synthetic methodologies for accessing this heterocyclic skeleton have received significant attention during the past decade.
Savela R, Méndez-Gálvez C.
europepmc +2 more sources
A C1-symmetric N-heterocyclic carbene catalysed oxidative spiroannulation of isatin-derived enals: highly enantioselective synthesis of spirooxindole δ-lactones. [PDF]
RSC Adv, 2018 A NHC-catalysed spiroannulation of isatin-derived enals and 1,3-dicarbonyl compounds has been developed, enabling enantioselective synthesis of synthetically important spirooxindole δ-lactones.
Lin JB +5 more
europepmc +2 more sources
SynOpenGreen-emissive spirooxindole fluorophores were efficiently synthesized through a K-10 clay-mediated [3+3] spiroannulation of bromine-isomerized Morita-Baylis-Hillman (MBH) adducts of isatin derivatives with anthracene.
Selvaraj Aruljothi +2 more
doaj +2 more sources
Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed C-H Functionalization and Spiroannulation. [PDF]
Angew Chem Int Ed Engl, 2015 Chirale Cp‐Rhodium‐Komplexe vermitteln die enantioselektive Enol‐dirigierte C(sp2)‐H‐Funktionalisierung und oxidative Anellierung mit Alkinen unter Bildung von Spiroindenen mit quartären Kohlenstoff‐Stereozentren. Entscheidend für hohe ee‐Werte sind offenbar eine hohe Selektivität zwischen zwei dirigierenden Gruppen sowie die Kontrolle der ...
Reddy Chidipudi S +3 more
europepmc +2 more sources
European Journal of Organic Chemistry, Volume 2022, Issue 25, July 7, 2022., 2022 Easily accessible isoxazol‐5(4H)‐ones are useful precursors of different heterocycles. In this work, the ruthenium‐catalyzed transformation of 4‐alkenyl‐substituted isoxazol‐5‐ones to 1H‐pyrrole derivatives is reported. Abstract Easily accessible isoxazol‐5(4H)‐ones are useful precursors of heterocycles.
Letizia Molteni +6 more
wiley +1 more source
Reductive Spiroannulation of Nitriles with Secondary Electrophiles
, 2016 The scope of reductive decyanation and spiroannulation reactions has been expanded to include secondary electrophiles for potentially useful transformations.
Matthew D. Morin (2096020) +1 more
core +2 more sources
Synthesis of 6-Methoxy-1-oxaspiro[4,5]deca-6,9-diene-8-one
Molecules, 2002 The synthesis of a new spirolactone is described. The title compound is obtained as a white solid in 46% yield from 3-(4-hydroxy-2-methoxyphenyl)propanoic acid using [Bis(trifluoroacetoxy)iodo]benzene (PIFA) as the oxidant.
Benjamin B. Fisher, Guy L. Plourde
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans +3 more
wiley +2 more sources
, 2023 A novel [4 + 1] dearomative spiroannulation of α-halo-β-naphthol and nitroolefin has been developed for the direct construction of various spiroisoxazolidines in high chemo- and diastereoselectivity.
Jingjing Liu +9 more
core +1 more source