Results 21 to 30 of about 490 (165)

One‐Pot Cascade Synthesis of Isoquinolinone‐Fused Quinoxalines Through Sequential Rh(III)/Pd(II) Catalysis

Advanced Synthesis &Catalysis, Volume 367, Issue 20, October 29, 2025.
A new one‐pot, dual catalytic strategy for the synthesis of polycyclic isoquinolinone‐fused quinoxalines from commercially available N‐(2‐acetamidophenyl)benzamides and 1,3‐diynes is reported. This transformation proceeds via Rh(III)/Pd(II)‐mediated sequential NH/CH activation/annulation. Detailed mechanistic studies elucidate the reaction pathway. A
Wei‐Jung Chiu, Indrajeet J. Barve, Hung‐Sheng Hsieh, Chung‐Ming Sun   +3 more
wiley   +1 more source

Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions

Advanced Synthesis &Catalysis, Volume 367, Issue 13, July 23, 2025.
Abstract Herein we present a novel one‐pot methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen
Javier Gómez‐Ayuso, Israel Carreira‐Barral, Roberto Quesada, María García‐Valverde   +3 more
wiley   +1 more source

Heterogeneously Catalyzed Cascade Oxidative Coupling/Dearomative Spirocyclization of Diarylamines: Facile Access to Spiroacridines

Advanced Synthesis &Catalysis, Volume 367, Issue 9, May 6, 2025.
Abstract Spirocyclic compounds, particularly spirocyclohexadienones, are important in pharmaceuticals due to their biological activity. In this study, we develop a catalytic cascade oxidative spirocyclization of diarylamines for the rapid access to highly functionalized spirocyclohexadienones. Using commercially available recyclable heterogeneous metal
Kenji Matsumoto, Naho Sato, Yoshinori Kobayashi, Kanako Date, Yasuko Okamoto, Touya Kariya, Tsukasa Hirokane, Masahiro Yoshida   +7 more
wiley   +1 more source

Synthesis of 3-spiroannulated hexahydro-6,8a-epoxyisoquinolines

Mendeleev Communications, 2002
The title compounds were synthesised by the intramolecular [4+2]-cycloaddition of 1-N-furfurylamino-1-allylcyclanes in the presence of acetic anhydride.
Varlamov A.V., Nikitina E.V., Zubkov F.I., Shurupova O.V., Chernyshev A.I.   +4 more
openaire   +3 more sources

From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis

ChemSusChem, Volume 17, Issue 8, April 22, 2024.
Catalysed synthetic methods, such as transition metals, organocatalysts, photocatalysts, iodine‐catalysed reaction, electrochemical reactions and green innovative methods are of great interest for the sustainable synthesis of heterocyclic compounds, important building blocks for several applications.
Carla Rizzo, Andrea Pace, Ivana Pibiri, Silvestre Buscemi, Antonio Palumbo Piccionello   +4 more
wiley   +1 more source

Aniline Derivatives from Lignin under Mild Conditions Enabled by Electrochemistry

ChemSusChem, Volume 17, Issue 3, February 8, 2024.
Electrochemical oxidation of lignin‐derived guaiacols & syringols leads to cyclohexadienone intermediates in moderate to good yields. These react with ethyl glycinate hydrochloride under mild conditions to afford lignin‐based anilines. This methodology can be incorporated to reductive catalytic fractionation processes towards selective obtention of 4 ...
Antonio A. Castillo‐Garcia, Christian Oliver Kappe, David Cantillo, Katalin Barta   +3 more
wiley   +1 more source

Syntheses of 1,2-annulated and 1-spiroannulated carbohydrate derivatives: Recent developments

Bioorganic & Medicinal Chemistry, 2012
A variety of different strategies has been used for the 1,2-annulation and the 1-spiroannulation of further rings to monosaccharides. This short review presents some recent methods to access such structures involving radical chemistry, cycloadditions, Michael reactions and metal-catalyzed transformations.
Awan, Shahid I., Werz, Daniel B.
openaire   +3 more sources

Temperature‐Controlled Dearomative [5+1] Spiroannulation and Formal [5+2] Cyclization of Indoles with Enynones: Divergent Synthesis of Spiro‐Indolenines and Dihydrocyclohepta[b]Indolones

Advanced Synthesis & Catalysis
We developed a temperature‐controlled intermolecular dearomative [5+1] spiroannulation and [5+2] cyclization of indoles with enynones, smoothly delivering a variety of spiroindolenines and dihydrocyclohepta[b]indolones under 40 °C and 80 °C, respectively.
Bin Dong, Zhiming Li, Wei Li, Jiang Deng, Junyuan Yan, Yihan Guo, Kaikai Wang, Shan Qian, Zhouyu Wang, Xiaolong He   +9 more
semanticscholar   +1 more source

Diastereoselective Spiroannulation of Phenolic Derivatives: Effect of Steric Hindrance on the Diastereoselectivity

International Journal of Chemistry, 2011
This study was aimed at determining the effect, if any, that steric factors may have on the diastereoselectivity in the spiroannulation of simple phenols. A series of phenols bearing different size substituents ortho to the phenolic hydroxyl were synthesized and spiroannulated to the corresponding spiroethers in good to excellent yields (76-94 ...
Guy L Plourde, Lyndia M. Susag
openaire   +2 more sources

Enantioselective palladium-catalyzed C(sp²)-C(sp²) σ bond activation of cyclopropenones by merging desymmetrization and (3 + 2) spiroannulation with cyclic 1,3-diketones. [PDF]

Chem Sci, 2021
Zhou HQ, Gu XW, Zhou XH, Li L, Ye F, Yin GW, Xu Z, Xu LW.   +7 more
europepmc   +1 more source