Isoindolinone Synthesis via One-Pot Type Transition Metal Catalyzed C-C Bond Forming Reactions. [PDF]
Chemistry, 2021 Isoindolinone motif can found in a large variety biologically and pharmaceutically active compounds. Due to the central role in a number of applications, the synthetic methodologies for accessing this heterocyclic skeleton have received significant attention during the past decade.
Savela R, Méndez-Gálvez C.
europepmc +2 more sources
Rhodium(III)‐Catalyzed C7‐Spiroannulation of Indolines with Maleimides: Facile Access to Aza‐Spiromulticycles [PDF]
Advanced Synthesis and CatalysisChao Pi, Yangjie Wu, Xiuling Cui
exaly +2 more sources
Probing chemical space with alkaloid-inspired libraries. [PDF]
Nat Chem, 2014 Screening of small molecule libraries is an important aspect of probe and drug discovery science. Numerous authors have suggested that bioactive natural products are attractive starting points for such libraries, due to their structural complexity and ...
McLeod MC +6 more
europepmc +7 more sources
I2–PPh3 mediated spiroannulation of unsaturated β-dicarbonyl compounds. The first synthesis of (±)-negundoin A [PDF]
, 2013 An efficient and stereoselective spiroannulation of unsaturated enols is reported. Unsaturated b-dicarbonyl compounds undergo cyclization by reaction with catalytic I2–PPh3, affording the corresponding spiro enol ether derivatives, with complete regio ...
Rubén Tapia +6 more
openalex +4 more sources
Green Synthesis and Catalysis, 2023 Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds.
Wei-Yi Pu, Xin-Yi Chen, Lin Dong
doaj +1 more source
Synthesis of spirocyclic enones by rhodium-catalyzed dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes [PDF]
, 2014 The dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes proceeds with high yields and regioselectivities under Rh(III) catalysis.
Best, Daniel +3 more
core +4 more sources
Preservable Chirality in Carbocation-Mediated Spiroannulation [PDF]
SynfactsDahui Zhao, Xinhang Chang
openaire +2 more sources
Gold(I) Catalysis Applied to the Stereoselective Synthesis of Indeno[2,1-b]thiochromene Derivatives and Seleno Analogues [PDF]
, 2022 A gold(I)-catalyzed cascade reaction for the stereoselective synthesis of sulfur- or selenium-containing indeno[1,2-b]chromene derivatives from o-(alkynyl)styrenes substituted at the triple bond with a thio- or seleno-aryl group is described.
Fernández Rodríguez, Manuel A. +5 more
core +2 more sources
Remote Construction of N-Heterocycles via 1,4-Palladium Shift-Mediated Double C-H Activation [PDF]
, 2022 In the past years, Pd0-catalyzed C(sp3)-H activation provided efficient and step-economical methods to synthesize carbo- and heterocycles via direct C(sp2)-C(sp3) bond formation.
Baudoin, Olivier +2 more
core +1 more source
Synthesis of N-(2,8-Dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yl) Acetamide and Benzamide
Molbank, 2009 The syntheses of two new spirolactones are described. Each compound was obtained as an off-white solid in 66% yields from 4-hydroxy-3-nitrobenzaldehyde.
Guy L. Plourde, Randy R. Spaetzel
doaj +1 more source