Results 21 to 30 of about 360 (157)
, 2022 The palladium-catalyzed divergent asymmetric synthesis of chiral spiro-furanindoline derivatives is described. The zwitterionic alkoxy π-allyl Pd(II) intermediate, generated catalytically from vinyl ethylene carbonate (VEC), could undergo ligand ...
Su Min Park (14248329) +3 more
core +1 more source
I2–PPh3 mediated spiroannulation of unsaturated b-dicarbonyl compounds. The first synthesis of (±)-negundoin A [PDF]
, 2013 An efficient and stereoselective spiroannulation of unsaturated enols is reported. Unsaturated b-dicarbonyl compounds undergo cyclization by reaction with catalytic I2–PPh3, affording the corresponding spiro enol ether derivatives, with complete regio ...
Chahboun, Rachid +6 more
core +1 more source
Electrophilic functionalisation of indoles [PDF]
, 2020 This Thesis describes efforts to develop improved methods to synthesise spirocyclic scaffolds based on indole through the development of a novel library of bis-electrophilic reagents.
Rossi-Ashton, James
core +5 more sources
Diastereoselective spiroannulation of phenolic derivatives: Effect of steric hindrance on the diastereoselectivity. [PDF]
, 2010 The objective of this study was to determine the effect, if any, that steric factors have on the oxidative spiroannulation of simple phenols bearing substituents that are increasing in size.
core +1 more source
Gold(I)-Catalyzed Ring-Expanding Spiroannulation of Cyclopropenones with Enynes
, 2016 The gold(I)-catalyzed ring-expanding spiroannulation of cyclopropenones with enynes is reported here. A molecule of water is incorporated into the products during the spiroannulation to afford spirocyclic cyclopentenones containing an alcohol ...
Takanori Matsuda (1830835) +1 more
core +1 more source
, 2022 Spiroannulation reactions are fundamental and invaluable for the synthesis of spirocyclic compounds. Presented herein are novel cascade reactions of aryl azomethine imines with cyclic diazo compounds leading to the formation of spirocyclic ...
Xinying Zhang (808783) +4 more
core +1 more source
Dearomatizing Spiroannulation Reagents: Direct Access to Spirocycles from Indoles and Dihalides [PDF]
Organic Letters, 2018 Unfunctionalized indoles can be directly converted into 3,3'-spirocyclic indolenines and indolines upon reaction with electrophilic dihalides in the presence of t-BuOK/BEt3. This double C-C bond forming reaction, which simultaneously generates a quaternary spirocyclic center, typically proceeds in high yield and has good functional group tolerance.
Liddon, John T R +3 more
openaire +4 more sources
, 2018 An N-heterocyclic carbene-catalyzed asymmetric [3 + 3] spiroannulation of β-ketothioamide was successfully developed. β-Ketothioamides exhibit an unusual reactivity to undergo a previously challenging lactamization reaction, and the desired spiro ...
Jia-Lu Zhang (3860683) +6 more
core +2 more sources
Advanced Synthesis &Catalysis, Volume 367, Issue 20, October 29, 2025.A new one‐pot, dual catalytic strategy for the synthesis of polycyclic isoquinolinone‐fused quinoxalines from commercially available N‐(2‐acetamidophenyl)benzamides and 1,3‐diynes is reported. This transformation proceeds via Rh(III)/Pd(II)‐mediated sequential NH/CH activation/annulation. Detailed mechanistic studies elucidate the reaction pathway. A
Wei‐Jung Chiu +3 more
wiley +1 more source
Green Synthesis and CatalysisSpirocyclic architectures represent one of the privileged three-dimensional scaffolds in pharmaceutical chemistry and drug discovery, while the new-skeletal synthesis of spiromolecules from simple starting materials remains a challenging task.
Zhiyuan Bao +4 more
doaj +1 more source