Results 31 to 40 of about 360 (157)

Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions

Advanced Synthesis &Catalysis, Volume 367, Issue 13, July 23, 2025.
Abstract Herein we present a novel one‐pot methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen
Javier Gómez‐Ayuso, Israel Carreira‐Barral, Roberto Quesada, María García‐Valverde   +3 more
wiley   +1 more source

EPR Evidence for the Origin of Nonlinear Effects in an Enantioselective Cu(II)-Catalyzed Spiroannulation

, 2019
Herein, we describe an enantioselective Cu­(II)-catalyzed spiroannulation of N-Boc-iminooxindoles with allylsilanes where a significant positive nonlinear effect (NLE) is observed.
Troy A. Stich (1332660), Annaliese K. Franz (1289460), Benjamin H. Shupe (1939126), Richard I. Sayler (1753987), R. David Britt (305724), Brittany M. Armstrong (6198716)   +5 more
core   +1 more source

Heterogeneously Catalyzed Cascade Oxidative Coupling/Dearomative Spirocyclization of Diarylamines: Facile Access to Spiroacridines

Advanced Synthesis &Catalysis, Volume 367, Issue 9, May 6, 2025.
Abstract Spirocyclic compounds, particularly spirocyclohexadienones, are important in pharmaceuticals due to their biological activity. In this study, we develop a catalytic cascade oxidative spirocyclization of diarylamines for the rapid access to highly functionalized spirocyclohexadienones. Using commercially available recyclable heterogeneous metal
Kenji Matsumoto, Naho Sato, Yoshinori Kobayashi, Kanako Date, Yasuko Okamoto, Touya Kariya, Tsukasa Hirokane, Masahiro Yoshida   +7 more
wiley   +1 more source

DMAP-Catalyzed [4+3] Spiroannulation of Pyrazolone-Derived Morita–Baylis–Hillman Carbonates with N‑(o‑Chloromethyl)aryl Amides to Forge Spiro[pyrazolone-azepine] Scaffolds

, 2023
A novel DMAP-catalyzed [4+3] spiroannulation of pyrazolone-derived Morita–Baylis–Hillman carbonates with N-(o-chloromethyl)aryl amides was developed.
Baomin Wang, Zahra Karimi, Xingfu Wei, Yue Huang (285485), Yue Huang, Zahra Karimi (4972795), Jingping Qu (556366), Jingping Qu, Xingfu Wei (9550307), Baomin Wang (174006)   +9 more
core   +1 more source

Synthesis of 3-spiroannulated hexahydro-6,8a-epoxyisoquinolines

Mendeleev Communications, 2002
The title compounds were synthesised by the intramolecular [4+2]-cycloaddition of 1-N-furfurylamino-1-allylcyclanes in the presence of acetic anhydride.
Varlamov A.V., Nikitina E.V., Zubkov F.I., Shurupova O.V., Chernyshev A.I.   +4 more
openaire   +3 more sources

From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis

ChemSusChem, Volume 17, Issue 8, April 22, 2024.
Catalysed synthetic methods, such as transition metals, organocatalysts, photocatalysts, iodine‐catalysed reaction, electrochemical reactions and green innovative methods are of great interest for the sustainable synthesis of heterocyclic compounds, important building blocks for several applications.
Carla Rizzo, Andrea Pace, Ivana Pibiri, Silvestre Buscemi, Antonio Palumbo Piccionello   +4 more
wiley   +1 more source

Aniline Derivatives from Lignin under Mild Conditions Enabled by Electrochemistry

ChemSusChem, Volume 17, Issue 3, February 8, 2024.
Electrochemical oxidation of lignin‐derived guaiacols & syringols leads to cyclohexadienone intermediates in moderate to good yields. These react with ethyl glycinate hydrochloride under mild conditions to afford lignin‐based anilines. This methodology can be incorporated to reductive catalytic fractionation processes towards selective obtention of 4 ...
Antonio A. Castillo‐Garcia, Christian Oliver Kappe, David Cantillo, Katalin Barta   +3 more
wiley   +1 more source

Cp*Co(III)-Catalyzed Dearomative [3 + 2] Spiroannulation of 2‑Alkenylphenols with Ynamides via C–H Activation

, 2019
An oxidative [3 + 2] C–H spiroannulation reaction of 2-alkenylphenols with ynamides has been developed toward the synthesis of spiro­[4,5]­decane derivatives.
Peng-Peng Lin (7355051), Qingjiang Li (404002), Xiang-Lei Han, Honggen Wang, Ji-Lin Li (3592577), Honggen Wang (1489543), Peng-Peng Lin, Qingjiang Li, Guo-Hua Ye (7239248), Ji-Lin Li, Xiang-Lei Han (1305126), Guo-Hua Ye   +11 more
core   +2 more sources

Rh(III)-Catalyzed Spiroannulation Reaction of N‑Aryl Nitrones with 2‑Diazo-1,3-indandiones: Synthesis of Spirocyclic Indole‑N‑oxides and Their 1,3-Dipolar Cycloaddition with Maleimides

, 2023
An efficient strategy for the preparation of spirocyclic indole-N-oxide compounds through a Rh(III)-catalyzed [4 + 1] spiroannulation reaction of N-aryl nitrones with 2-diazo-1,3-indandiones as C1 synthons under extremely mild conditions is presented ...
Zhaotong Wei (14761249), Xuesen Fan (808785), Yuanqing Zhu (9576890), Shenghai Guo (1490353), Ziyi Zhang (4269196)   +4 more
core   +1 more source

Asymmetric Construction of Spiro[thio­pyrano­indole-benzo­isothiazole] Scaffold via a Formal [3 + 3] Spiroannulation

, 2015
An enantioselective formal thio­[3 + 3] spiroannulation reaction of indoline-2-thiones to 1-azadienes has been developed by the use of a quinine-derived bifunctional tertiary amine-thiourea catalyst, which furnished a series of optically active spiro ...
Xing-Wang Wang (1538014), Hai-Yan Li (692428), Shao-Jie Yin (1538011), Wei-Qun Zhou (1538005), Xiang Chen (10398), Jun-Qi Zhang (1538008)   +5 more
core   +1 more source