Results 41 to 50 of about 754 (188)
Ru(II)/PEG-400: A green synthesis of indolyl-oxindoles and indolyl-cyclohexane-dione hybrids as potential antimicrobial agents [PDF]
, 2023 A green and sustainable methodology has been successfully employed for the synthesis of 3-Indolyl-3-hydroxy oxindoles and 3-indolyl-3-hydroxy-5,5-dimethylcyclohexane-1,3-dione derivatives using Ru(II)/PEG-400 as a homogeneous recyclable catalytic system ...
Kasralikar, Hanmant M +2 more
core +2 more sources
, 2015 International audienceAn exciting isatin-thiazoline hybrid molecule 2 having -C=N-N=C- linkage has been synthesized in 88% yield by the reaction of 5-fluoroisatin with N-(4-fluorophenyl)hydrazinecarbothioamide followed by condensation of the resultant ...
Ahmad, Maqbool +4 more
core +3 more sources
Spiro[1H-azulenium-1,9 '-fluorene] perchlorate. Intramolecular charge-transfer interaction between orthogonally arranged units of the azulenium cation and fluorene [PDF]
, 2008 ArticleTETRAHEDRON LETTERS.
36527 +7 more
core +1 more source
Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position [PDF]
, 2021 Pyrazolone [2,4-dihydro-3H-pyrazol-4-one] represents one of the most important five-membered nitrogen heterocycles which is present in numerous pharmaceutical drugs and molecules with biological activity.
Blay Llinares, Gonzalo +3 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans +3 more
wiley +1 more source
Total syntheses of natural products containing spirocarbocycles [PDF]
, 2015 The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral
Baxendale, I.R., Smith, L.K.
core +2 more sources
Advanced Synthesis &Catalysis, Volume 367, Issue 20, October 29, 2025.A new one‐pot, dual catalytic strategy for the synthesis of polycyclic isoquinolinone‐fused quinoxalines from commercially available N‐(2‐acetamidophenyl)benzamides and 1,3‐diynes is reported. This transformation proceeds via Rh(III)/Pd(II)‐mediated sequential NH/CH activation/annulation. Detailed mechanistic studies elucidate the reaction pathway. A
Wei‐Jung Chiu +3 more
wiley +1 more source
Synthesis of polycyclic natural products [PDF]
, 2003 Highly oxidized polycyclic natural products are abundant in nature and have diverse biological activities. Hyperforin has been identified as the sole constituent responsible for the antidepressant characteristic of St. John\u27s wort.
Nguyen, Tuan Hoang
core +5 more sources
Advanced Synthesis &Catalysis, Volume 367, Issue 13, July 23, 2025.Abstract Herein we present a novel one‐pot methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen
Javier Gómez‐Ayuso +3 more
wiley +1 more source
Applied Organometallics: Cp*Co(III)-Catalysed C-H Functionalisation as a Maturing Tool for the Synthesis of Heterocyclic Compounds [PDF]
, 2020 Heterocycle compounds are prevalent throughout the natural world and therefore it is unsurprising that they have become a key component in many pharmaceutically relevant molecules.
Hamilton , Alex +1 more
core +1 more source