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Combinatorial Chemistry

CHIMIA, 2000
In many areas of chemical synthesis, drug discovery, and materials research, combinatorial approaches are becoming more and more important. One of the most serious bottlenecks in this area is the chemical analysis and screening of the products ...
Renato Zenobi
doaj   +7 more sources

Structurally divergent dynamic combinatorial chemistry on racemic mixtures [PDF]

Nature Communications, 2020
Structurally divergent reactions on racemic mixtures, which produce distinct chemical species from an enantiomeric mixture, are extremely rare in the literature.
Tiberiu-M. Gianga, G. Dan Pantoș
doaj   +2 more sources

Mesofluidic devices for DNA-programmed combinatorial chemistry. [PDF]

PLoS ONE, 2012
Hybrid combinatorial chemistry strategies that use DNA as an information-carrying medium are proving to be powerful tools for molecular discovery. In order to extend these efforts, we present a highly parallel format for DNA-programmed chemical library ...
Rebecca M Weisinger, Robert J Marinelli, S Jarrett Wrenn, Pehr B Harbury   +3 more
doaj   +2 more sources

The RNA-First Fallacy: Conflating Evolutionary Ancestry with Prebiotic Primacy [PDF]

Life
The RNA-World hypothesis remains the most widely accepted framework in origins-of-life research, anchored in compelling biochemical evidence for RNA’s deep evolutionary ancestry.
Amit Kahana
doaj   +2 more sources

Introduction:  Combinatorial Chemistry [PDF]

Chemical Reviews, 1997
Jack W Szostak
exaly   +3 more sources

Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange [PDF]

Nature Communications, 2021
Andrea Canal-Martín, Ruth Perez-Fernandez   +1 more
exaly   +2 more sources

Direct C(sp3)–H allylation of 2-alkylpyridines with Morita–Baylis–Hillman carbonates via a tandem nucleophilic substitution/aza-Cope rearrangement

Beilstein Journal of Organic Chemistry, 2021
A base- and catalyst-free C(sp3)–H allylic alkylation of 2-alkylpyridines with Morita–Baylis–Hillman (MBH) carbonates is described. A plausible mechanism of the reaction might involve a tandem SN2’ type nucleophilic substitution followed by an aza-Cope ...
Siyu Wang, Lianyou Zheng, Shutao Wang, Shulin Ning, Zhuoqi Zhang, Jinbao Xiang   +5 more
doaj   +1 more source

The Effects of Combinatorial Chemistry and Technologies on Drug Discovery and Biotechnology – a Mini Review

Nova Biotechnologica et Chimica, 2014
The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto, Fassina Giorgio, Frecer Vladimir, Miertus Stanislav   +3 more
doaj   +1 more source

Expression and Purification of Glycosyltransferase DnmS from Streptomyces peucetius ATCC 27952 and Study on Catalytic Characterization of Its Reverse Glycosyltransferase Reaction

Microorganisms, 2023
Anthracyclines are an important class of natural antitumor drugs. They have a conservative aromatic tetracycline backbone that is substituted with different deoxyglucoses.
Liyan Yang, Huimin Zhou, Guiguang Chen, Hongliang Li, Dengfeng Yang, Lixia Pan   +5 more
doaj   +1 more source

Combinatorial Chemistry: A Guide for Librarians.

Issues in Science and Technology Librarianship, 2002
In the 1980s a need to synthesize many chemical compounds rapidly and inexpensively spawned a new branch of chemistry known as combinatorial chemistry.
Philip Barnett
doaj   +1 more source