Results 21 to 30 of about 42,234 (281)

Dynamic combinatorial libraries of complexes with oligopyridine ligands [PDF]

, 2006
Chapter 1 gives a background of some achievements reached in the fields of dynamic combinatorial libraries, 2,2´-bipyridine and 2,2´:6´,2´´-terpyridine chemistry, and ferrocenes compounds in the years preceding the present work.
Brisig, Barbara
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The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

Acta Chimica Slovenica, 2017
Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj   +1 more source

Combinatorial chemistry [PDF]

Current Opinion in Chemical Biology, 1998
J A, Ellman, M A, Gallop
  +8 more sources

An overview of the cycloaddition chemistry of fulvenes and emerging applications

Beilstein Journal of Organic Chemistry, 2019
The unusual electronic properties and unique reactivity of fulvenes have interested researchers for over a century. The propensity to form dipolar structures at relatively low temperatures and to participate as various components in cycloaddition ...
Ellen Swan, Kirsten Platts, Anton Blencowe   +2 more
doaj   +1 more source

Stability Evaluation and Degradation Studies of DAC^® Hyaluronic-Polylactide Based Hydrogel by DOSY NMR Spectroscopy

Biomolecules, 2020
The stability and the degradation of polymers in physiological conditions are very important issues in biomedical applications. The copolymer of hyaluronic acid and poly-D,L-lactic acid (made available in a product called DAC®) produces a hydrogel which ...
Tatiana Guzzo, Fabio Barile, Cecilia Marras, Davide Bellini, Walter Mandaliti, Ridvan Nepravishta, Maurizio Paci, Alessandra Topai   +7 more
doaj   +1 more source

The synthesis of a small library of prospective growth hormone secretagogues [PDF]

Journal of the Serbian Chemical Society, 1999
Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues.
Pejović Vojislav, Šoškić Vukić, Joksimović Jelena   +2 more
doaj   +3 more sources

Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases

Nature Communications, 2020
Terpene cyclases catalyze the formation of diverse hydrocarbon scaffolds found in terpenoids. Here, the authors report the cryptic function of class I terpene cyclases as aromatic prenyltransferases and the universality of this cryptic feature is ...
Haibing He, Guangkai Bian, Corey J. Herbst-Gervasoni, Takahiro Mori, Stephen A. Shinsky, Anwei Hou, Xin Mu, Minjian Huang, Shu Cheng, Zixin Deng, David W. Christianson, Ikuro Abe, Tiangang Liu   +12 more
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Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production

, 2012
10.1021/co300007aACS Combinatorial Science147395 ...
Kim, Jaoon Y. H., Lee, Y., Chang, Young-Tae, Ha, H.-H., Lee, Woo Sirl, Lee, J.W., Chang, Y.-T., Bork, J.T., Lee, W.S., Vendrell, M., Ha, Hyung-Ho, Kim, J.Y.H., Lee, Y, Bork, Jacqueline T., Lee, Jae Wook, Vendrell, Marc   +15 more
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Sobre o uso de métodos quimiométricos em química combinatória The use of chemometric methods on combinatorial chemistry

Química Nova, 2000
Combinatorial chemistry has emerged as a tool to circumvent a major problem of pharmaceutical industries to discover new lead compounds. A rapid and massive evaluation of a myriad of newly synthesised compounds can be carried out. Combinatorial synthesis
Andrei Leitão, Carlos A. Montanari, Claudio L. Donnici   +2 more
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Aplicações da química combinatória no desenvolvimento de fármacos Applications of combinatorial Chemistry to drug development

Química Nova, 2001
Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead ...
Ricardo L. Araújo Dias, Arlene G. Corrêa   +1 more
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