Results 21 to 30 of about 2,494,908 (263)
Beilstein Journal of Organic Chemistry, 2021 A base- and catalyst-free C(sp3)–H allylic alkylation of 2-alkylpyridines with Morita–Baylis–Hillman (MBH) carbonates is described. A plausible mechanism of the reaction might involve a tandem SN2’ type nucleophilic substitution followed by an aza-Cope ...
Siyu Wang +5 more
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Microorganisms, 2023 Anthracyclines are an important class of natural antitumor drugs. They have a conservative aromatic tetracycline backbone that is substituted with different deoxyglucoses.
Liyan Yang +5 more
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Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]
, 2013 Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Otto, Sijbren, +9 more
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Discovery of Antibacterial Manganese(I) Tricarbonyl Complexes through Combinatorial Chemistry [PDF]
, 2023 The continuous rise of antimicrobial resistance is a serious threat to human health and already causing hundreds of thousands of deaths each year. While natural products and synthetic organic small molecules have provided the majority of our current ...
Giorgio, Pelosi +3 more
core +2 more sources
Nova Biotechnologica et Chimica, 2014 The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial ...
Seneci Pierfausto +3 more
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Combinatorial Chemistry: A Guide for Librarians.
Issues in Science and Technology Librarianship, 2002 In the 1980s a need to synthesize many chemical compounds rapidly and inexpensively spawned a new branch of chemistry known as combinatorial chemistry.
Philip Barnett
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AlgM4: A New Salt-Activated Alginate Lyase of the PL7 Family with Endolytic Activity
Marine Drugs, 2018 Alginate lyases are a group of enzymes that catalyze the depolymerization of alginates into oligosaccharides or monosaccharides. These enzymes have been widely used for a variety of purposes, such as producing bioactive oligosaccharides, controlling the ...
Guiyuan Huang +7 more
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A semantic datagrid for combinatorial chemistry [PDF]
The 6th IEEE/ACM International Workshop on Grid Computing, 2005., 2005 The CombeChem project has designed and deployed an e-science infrastructure using a combination of grid and semantic Web technologies. In this paper we describe the datagrid element of the project, which provides a platform for sophisticated scientific queries and a rich record of experimental data and its provenance.
Kieron R. Taylor +5 more
openaire +3 more sources
Dynamic combinatorial chemistry at the phospholipid bilayer interface [PDF]
, 2010 Background: Molecular recognition at the environment provided by the phospholipid bilayer interface plays an important role in biology and is subject of intense investigation. Dynamic combinatorial chemistry is a powerful approach for exploring molecular
Otto, Sijbren, +12 more
core +6 more sources
Development of Advanced Macrosphelides: Potent Anticancer Agents
Molecules, 2015 Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography ...
Seung-Mann Paek
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