ALA‐A2 Is a Novel Anticancer Peptide Inspired by Alpha‐Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and In Vitro Experimental Validation [PDF]
Global Challenges, 2023 Anticancer peptides (ACPs) are rising as a new strategy for cancer therapy. However, traditional laboratory screening to find and identify novel ACPs from hundreds to thousands of peptides is costly and time consuming.
Tassanee Lerksuthirat +8 more
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Pharmaceuticals, 2023 Peptides, or short chains of amino-acid residues, are becoming increasingly important as active ingredients of drugs and as crucial probes and/or tools in medical, biotechnological, and pharmaceutical research.
Marko Jukič +3 more
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Analysis of Compositional Bias in a Commercial Phage Display Peptide Library by Next-Generation Sequencing [PDF]
Viruses, 2022 The principal presumption of phage display biopanning is that the naïve library contains an unbiased repertoire of peptides, and thus, the enriched variants derive from the affinity selection of an entirely random peptide pool.
Ane Beth Sloth +6 more
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Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. [PDF]
PLoS Biology, 2004 The use of peptide libraries for the identification and characterization of T cell antigen peptide epitopes and mimotopes has been hampered by the need to form complexes between the peptides and an appropriate MHC molecule in order to construct a ...
Frances Crawford +4 more
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Discovery of Surfactant-Like Peptides from a Phage-Displayed Peptide Library [PDF]
Viruses, 2020 Peptides with specific affinities for various materials have been identified in the past three decades and utilized in materials science and engineering. A peptide’s capability to specifically interact with materials is not naturally derived but screened
Toshiki Sawada +3 more
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Design of fully synthetic signal peptide library and its use for enhanced secretory production of recombinant proteins in Corynebacterium glutamicum [PDF]
Microbial Cell FactoriesBackground Corynebacterium glutamicum is an attractive host for secretory production of recombinant proteins, including high-value industrial enzymes and therapeutic proteins.
Eun Jung Jeon +3 more
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PLoS ONE, 2010 BackgroundA peptide able to transduce cardiac tissue specifically, delivering cargoes to the heart, would be of significant therapeutic potential for delivery of small molecules, proteins and nucleic acids.
Maliha Zahid +5 more
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Algorithm-supported, mass and sequence diversity-oriented random peptide library design [PDF]
Journal of Cheminformatics, 2019 Random peptide libraries that cover large search spaces are often used for the discovery of new binders, even when the target is unknown. To ensure an accurate population representation, there is a tendency to use large libraries.
Daniela Kalafatovic +3 more
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Frontiers in Immunology, 2022 Respiratory Syncytial Virus (RSV) is ubiquitous and re-infection with both subtypes (RSV/A and RSV/B) is common. The fusion (F) protein of RSV is antigenically conserved, induces neutralizing antibodies, and is a primary target of vaccine development ...
Brittani N. Blunck +11 more
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In Silico Analysis of Neutralizing Antibody Epitopes on The Hepatitis C Virus Surface Glycoproteins [PDF]
Cell Journal, 2023 Objective: Despite of antiviral drugs and successful treatment, an effective vaccine against hepatitis C virus (HCV)infection is still required. Recently, bioinformatic methods same as prediction algorithms, have greatly contributed tothe use of peptides
Raziyeh Zareh-Khoshchehreh +4 more
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