Results 1 to 10 of about 266,976 (317)

The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]

Open Biology, 2016
Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel, Hannah R. Belsham, Alexandra J. Rathbone, Bill Wickstead, Christopher Gell, Claire T. Friel   +5 more
doaj   +1 more source

Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

eLife, 2022
Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2, and -3 superfamilies against cytoplasmic dynein-1.
Allison M Gicking, Tzu-Chen Ma, Qingzhou Feng, Rui Jiang, Somayesadat Badieyan, Michael A Cianfrocco, William O Hancock   +6 more
doaj   +1 more source

TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes [PDF]

Open Biology, 2014
Chromosomal instability can arise from defects in chromosome–microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes.
Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas Levin, Joanna Clark, Viji M. Draviam   +5 more
doaj   +1 more source

Silencing TUBB3 Expression Destroys the Tegument and Flame Cells of Echinococcus multilocularis Protoscoleces

Animals, 2022
Alveolar echinococcosis (AE), caused by infection with the larvae of Echinococcus multilocularis, is a neglected tropical disease and zoonosis that causes remarkable morbidity in humans and has economic importance in the livestock industry worldwide. The
Qiqi Shi, Congshan Liu, Lele Huo, Yi Tao, Haobing Zhang   +4 more
doaj   +1 more source

SRC Kinase-Mediated Tyrosine Phosphorylation of TUBB3 Regulates Its Stability and Mitotic Spindle Dynamics in Prostate Cancer Cells

Pharmaceutics, 2022
Tubulin is an integral part of the cytoskeleton and plays a pivotal role in cellular signaling, maintenance, and division. β-tubulin is also the molecular target for taxane compounds such as docetaxel (DTX) and cabazitaxel (CTX), both first-line ...
Alan Alfano, Jin Xu, Xi Yang, Dhanraj Deshmukh, Yun Qiu   +4 more
doaj   +1 more source

Computational Prediction and Experimental Validation of the Unique Molecular Mode of Action of Scoulerine

Molecules, 2022
Scoulerine is a natural compound that is known to bind to tubulin and has anti-mitotic properties demonstrated in various cancer cells. Its molecular mode of action has not been precisely known.
Mahshad Moshari, Qian Wang, Marek Michalak, Mariusz Klobukowski, Jack Adam Tuszynski   +4 more
doaj   +1 more source

Cytotoxic T Lymphocyte Activation Signals Modulate Cytoskeletal Dynamics and Mechanical Force Generation

Frontiers in Immunology, 2022
Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing infected cells. Antigen presenting cells (APCs), such as dendritic cells, present pathogenic peptides to the T cell receptor on the CTL surface and co ...
Aashli Pathni, Altuğ Özçelikkale, Altuğ Özçelikkale, Ivan Rey-Suarez, Lei Li, Scott Davis, Nate Rogers, Zhengguo Xiao, Zhengguo Xiao, Arpita Upadhyaya, Arpita Upadhyaya, Arpita Upadhyaya   +11 more
doaj   +1 more source

In vitro reconstitution of branching microtubule nucleation

eLife, 2020
Eukaryotic cell division requires the mitotic spindle, a microtubule (MT)-based structure which accurately aligns and segregates duplicated chromosomes.
Ammarah Tariq, Lucy Green, J Charles G Jeynes, Christian Soeller, James G Wakefield   +4 more
doaj   +1 more source

O‐GlcNAcylation Regulates Centrosome Behavior and Cell Polarity to Reduce Pulmonary Fibrosis and Maintain the Epithelial Phenotype

Advanced Science, 2023
O‐GlcNAcylation functions as a cellular nutrient and stress sensor and participates in almost all cellular processes. However, it remains unclear whether O‐GlcNAcylation plays a role in the establishment and maintenance of cell polarity, because mice ...
Fan Yu, Song Yang, Hua Ni, Dai Heng, Xuemei Wu, Mulin Yang, Xinming Zhang, Yuxin Cao, Yandong Pei, Di An, Dengwen Li, Dayong Liu, Lin Liu, Leiting Pan, Quan Chen, Xueliang Zhu, Jun Zhou   +16 more
doaj   +1 more source

Tubulin Post-translational Modifications: Potential Therapeutic Approaches to Heart Failure

Frontiers in Cell and Developmental Biology, 2022
In recent decades, advancing insights into the mechanisms of cardiac dysfunction have focused on the involvement of microtubule network. A variety of tubulin post-translational modifications have been discovered to fine-tune the microtubules’ properties ...
Chang Liu, Yuwen Chen, Yao Xie, Meixiang Xiang   +3 more
doaj   +1 more source