A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity [PDF]
Nature Communications, 2018 A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes.
Erika Holzbaur +2 more
exaly +4 more sources
The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor
eLife, 2022 Dynein harnesses ATP hydrolysis to move cargo on microtubules in multiple biological contexts. Dynein meets a unique challenge in meiosis by moving chromosomes tethered to the nuclear envelope to facilitate homolog pairing essential for gametogenesis ...
Ritvija Agrawal +7 more
doaj +2 more sources
Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
Nature Communications, 2021 Mitochondria are transported along microtubules by opposing kinesin and dynein motors. Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear how TRAKs coordinate these motors. We used single-molecule imaging of cell
Adam R. Fenton +3 more
doaj +2 more sources
The cytoplasmic dynein transport machinery and its many cargoes
Nature Reviews Molecular Cell Biology, 2018 Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells. Dynein has critical roles both in interphase and during cell division.
William Redwine +2 more
exaly +2 more sources
LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes
Nature Cell Biology, 2020 Cytoplasmic dynein-1 is a molecular motor that drives nearly all minus-end-directed microtubule-based transport in human cells, performing functions that range from retrograde axonal transport to mitotic spindle assembly1,2.
John Patrick Gillies +1 more
exaly +2 more sources
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated
Cell, 2017 Summary Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules.
Kai Zhang +2 more
exaly +2 more sources
Nature Cell Biology, 2020 Dynein is a microtubule motor that transports many different cargos in various cell types and contexts. How dynein is regulated to perform these activities with spatial and temporal precision remains unclear.
Matthew Marzo +2 more
exaly +2 more sources
Human dynein–dynactin is a fast processive motor in living cells [PDF]
eLifeMinus-end directed transport along microtubules in eukaryotes is primarily mediated by cytoplasmic dynein and its cofactor dynactin. Significant advances have been made in recent years characterizing human dynein–dynactin structure and function using in ...
Vikash Verma +2 more
doaj +2 more sources
Lissencephaly-1 is a context-dependent regulator of the human dynein complex
eLife, 2017 The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach +6 more
doaj +2 more sources
Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction
eLife, 2019 Cytoplasmic dynein plays critical roles within the developing and mature nervous systems, including effecting nuclear migration, and retrograde transport of various cargos.
Matthew G Marzo +5 more
doaj +2 more sources