Results 21 to 30 of about 39,736 (248)

The role of motor proteins in endosomal sorting [PDF]

, 2011
Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Sylvie D Hunt, David J Stephens, Stephens, DJ   +3 more
core   +1 more source

The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation [PDF]

, 2010
Cytoplasmic dynein in filamentous fungi accumulates at microtubule plus-ends near the hyphal tip, which is important for minus-end-directed transport of early endosomes. It was hypothesized that dynein is switched on at the plus-end by cargo association.
Abenza, Juan F, Zhuang, Lei, Peñalva, Miguel Ángel, Xiang, Xin, Abenza, Juan F., Jun Zhang, Miguel A. Peñalva, Young Lee, Lee, Young, Juan F. Abenza, Xin Xiang, Lei Zhuang, Peñalva, Miguel A, Zhang, Jun   +13 more
core   +1 more source

Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]

, 2009
Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Hazel P Williams, Greensmith Linda, Francesca Achilli, Ruth Chia, Elizabeth M. C. Fisher, Hazel P. Williams, Fisher Elizabeth M. C., Achilli, F., Chia, R, Bryson, J.B., Bros-Facer, V., Greensmith, L., Bros-Facer, V, Banks, G.T., Bryson, JB, Banks, GT, Fisher, EMC, Bros-Facer Virginie, Linda Greensmith, Fisher, E.M.C., Banks Gareth T., Chia, R., Gareth T Banks, Williams, HP, Greensmith, L, Williams Hazel P., Elizabeth M C Fisher, J Barney Bryson, Gareth T. Banks, Virginie Bros-Facer, Achilli Francesca, Williams, H.P., Bryson J. Barney, Chia Ruth, J. Barney Bryson, Achilli, F   +35 more
core   +1 more source

The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly

Biology Open, 2021
Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD).
Petra zur Lage, Zhiyan Xi, Jennifer Lennon, Iain Hunter, Wai Kit Chan, Alfonso Bolado Carrancio, Alex von Kriegsheim, Andrew P. Jarman   +7 more
doaj   +1 more source

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice [PDF]

, 2005
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS remains unclear, mutations in Cu/Zn superoxide dismutase (SOD1) account for
Dairin Kieran, Martin, J, Joanne Martin, Schiavo, G, Giampietro Schiavo (107907), Dick, JRT, Greensmith, L., Joanne Martin (11260388), Bohnert, S, Hafezparast, M., Elizabeth M.C. Fisher, Fisher, EMC, Linda Greensmith, Stephanie Bohnert (16066082), Martin, J., Majid Hafezparast (4461484), Fisher, E.M.C., James R T Dick (16066085), Majid Hafezparast, Greensmith, L, Linda Greensmith (252146), Giampietro Schiavo, Kieran, D., Bohnert, S., Stephanie Bohnert, James R.T. Dick, Dairin Kieran (7953794), Dick, J.R.T., Kieran, D, Hafezparast, M, Schiavo, G., Elizabeth M C Fisher (16062626)   +31 more
core   +1 more source

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

Nature Communications, 2021
Mitochondria are transported along microtubules by opposing kinesin and dynein motors. Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear how TRAKs coordinate these motors. We used single-molecule imaging of cell
Adam R. Fenton, Cecilia R. Petruconis, Thomas A. Jongens, Erika L. F. Holzbaur   +3 more
doaj   +1 more source

Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction [PDF]

, 2013
Amanda E. Siglin is with Thomas Jefferson University, Shangjin Sun is with University of Delaware, Jeffrey K. Moore is with Washington University in Saint Louis, Sarah Tan is with UT Austin, Martin Poenie is with UT Austin, James D.
Shangjin Sun (399678), Tatyana Polenova, Lear James D., Tan Sarah, Shangjin Sun, Polenova, Tatyana, James D Lear, Martin Poenie, Lear, James D, Williams John C., Amanda E Siglin, Williams, John C, John C. Williams (262561), Cooper, John A., Siglin, Amanda E., Lear, James D., Tatyana Polenova (226142), Sun Shangjin, Williams, John C., Sarah Tan, Martin Poenie (399681), James D. Lear (399682), Siglin, Amanda E, Sarah Tan (399680), Tan, Sarah, John C Williams, Sun, Shangjin, Moore, Jeffrey K., Cooper, John A, Siglin Amanda E., John A Cooper, Amanda E. Siglin (399677), Jeffrey K Moore, Cooper John A., Polenova Tatyana, Poenie Martin, Poenie, Martin, John A. Cooper (170679), Moore Jeffrey K., Moore, Jeffrey K, Jeffrey K. Moore (399679)   +40 more
core   +2 more sources

Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells. [PDF]

PLoS ONE, 2009
BACKGROUND:Cytoplasmic dynein complex is a large multi-subunit microtubule (MT)-associated molecular motor involved in various cellular functions including organelle positioning, vesicle transport and cell division.
Takuya Kobayashi, Takashi Murayama
doaj   +1 more source

LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons

Frontiers in Molecular Neuroscience, 2022
Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein).
Jai P. Pandey, Liang Shi, Remi A. Brebion, Deanna S. Smith   +3 more
doaj   +1 more source

Regulation of chromosome congression : focus on the function of hSpindly and the kinetochore recruitment of the Ska complex [PDF]

, 2011
Mitosis is a process in which cells divide their genetic materials equally into two daughter cells. During mitosis, specialized structures called kinetochores (KTs), located at the centromeric regions of chromosomes, are captured by microtubules (MTs ...
Chan, Ying Wai
core   +1 more source