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The cytoskeleton and disease [PDF]

The Journal of Pathology, 2004
AbstractCytoskeletal research in recent years has revolutionized cell biology and biomedicine. The cytoskeleton spans the cytoplasm and interconnects the cell nucleus with the extracellular matrix, thereby forming a structural link between molecules involved in cell communication on the one hand, and gene expression on the other. Since the cytoskeleton
Frans C S, Ramaekers, Fred T, Bosman
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SiR-DNA/SiR–Hoechst-induced chromosome entanglement generates severe anaphase bridges and DNA damage

Life Science Alliance, 2023
Live-cell imaging-based study calls for caution when using SiR-DNA, as it induces chromosome entanglement that severely impairs sister chromatid segregation in mitosis, consequently causing DNA damage.
Girish Rajendraprasad, Sergi Rodriguez-Calado, Marin Barisic   +2 more
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CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly

Nature Communications, 2023
Accurate chromosome segregation in mitosis depends on multiprotein structures called kinetochores that are built on the centromeric region of sister chromatids and serve to capture mitotic spindle microtubules.
Susana Eibes, Girish Rajendraprasad, Claudia Guasch-Boldu, Mirela Kubat, Yulia Steblyanko, Marin Barisic   +5 more
doaj   +1 more source

Composition and function of the C1b/C1f region in the ciliary central apparatus

Scientific Reports, 2021
Motile cilia are ultrastructurally complex cell organelles with the ability to actively move. The highly conserved central apparatus of motile 9 × 2 + 2 cilia is composed of two microtubules and several large microtubule-bound projections, including the ...
Ewa Joachimiak, Anna Osinka, Hanan Farahat, Bianka Świderska, Ewa Sitkiewicz, Martyna Poprzeczko, Hanna Fabczak, Dorota Wloga   +7 more
doaj   +1 more source

Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both?

Frontiers in Immunology, 2023
Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen, Elena Ockfen, Liza Filali, Diogo Pereira Fernandes, Diogo Pereira Fernandes, Céline Hoffmann, Clément Thomas   +6 more
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Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus

Frontiers in Cell and Developmental Biology, 2023
The actin cytoskeleton plays a critical role in cancer cell invasion and metastasis; however, the coordination of its multiple functions remains unclear. Actin dynamics in the cytoplasm control the formation of invadopodia, which are membrane protrusions
Takouhie Mgrditchian, Joshua Brown-Clay, Céline Hoffmann, Tanja Müller, Liza Filali, Elena Ockfen, Xianqing Mao, Flora Moreau, Carla Pou Casellas, Tony Kaoma, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Clément Thomas   +16 more
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The Bacterial Cytoskeleton [PDF]

CBE—Life Sciences Education, 2006
One of the pleasures of teaching introductory biology courses is learning new things about old, familiar subjects … such as the differences between eukaryotes and prokaryotes. For a eukaryotic cell biologist, such learning usually entails examining how bacteria function, in ways other than how they replicate and transcribe DNA and how they synthesize ...
Yu-Ling, Shih, Lawrence, Rothfield
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C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress

Cells, 2022
ER distribution depends on microtubules, and ER homeostasis disturbance activates the unfolded protein response resulting in ER remodeling. CDK5RAP3 (C53) implicated in various signaling pathways interacts with UFM1-protein ligase 1 (UFL1), which ...
Anastasiya Klebanovych, Stanislav Vinopal, Eduarda Dráberová, Vladimíra Sládková, Tetyana Sulimenko, Vadym Sulimenko, Věra Vosecká, Libor Macůrek, Agustin Legido, Pavel Dráber   +9 more
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Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies: A Combination of Intrinsic Genomic Instability and Exocytosis Defects at the Immunological Synapse

Frontiers in Immunology, 2020
Congenital defects of the immune system called primary immunodeficiency disorders (PID) describe a group of diseases characterized by a decrease, an absence, or a malfunction of at least one part of the immune system.
Jérôme Mastio, Mezida B. Saeed, Hannah Wurzer, Max Krecke, Lisa S. Westerberg, Clément Thomas   +5 more
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The LisH Domain-Containing N-Terminal Fragment is Important for the Localization, Dimerization, and Stability of Katnal2 in Tetrahymena

Cells, 2020
Katanin-like 2 protein (Katnal2) orthologs have a tripartite domain organization. Two highly conserved regions, an N-terminal LisH (Lis-homology) domain and a C-terminal AAA catalytic domain, are separated by a less conserved linker.
Ewa Joachimiak, Ewa Waclawek, Michal Niziolek, Anna Osinka, Hanna Fabczak, Jacek Gaertig, Dorota Wloga   +6 more
doaj   +1 more source