Results 31 to 40 of about 321,372 (214)
Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly
Nature Communications, 2022 Mitotic spindle assembly is not fully understood. This work reveals that kinetochores drive the coarsening of a uniform microtubule array into bundles, which promote spindle formation and chromosome segregation fidelity.
Jurica Matković +6 more
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Regulation of actin cytoskeleton via photolithographic micropatterning
Journal of Innovative Optical Health Sciences, 2023 Actin cytoskeleton plays crucial roles in various cellular functions. Extracellular matrix (ECM) can modulate cell morphology by remodeling the internal cytoskeleton.
Fulin Xing +9 more
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Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells
Molecules, 2020 Microtubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division.
Filip Borys +3 more
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Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect.
Sacnicte Ramirez-Rios +9 more
doaj +1 more source
Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma
Frontiers in Genetics, 2023 Background: Cytoskeleton-associated protein 2-like protein (CKAP2L) is thought to promote the progression of glioma, breast cancer, and ovarian cancer. However, the role of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma
Zhi Liu +6 more
doaj +1 more source
A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation [PDF]
, 2014 The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is
Blanchard, Guy B. +4 more
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DNA damage and repair: underlying mechanisms leading to microcephaly
Frontiers in Cell and Developmental Biology, 2023 DNA-damaging agents and endogenous DNA damage constantly harm genome integrity. Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in repairing lesions and preventing mutations in the basic structure of the DNA ...
Jessica Honorato Ribeiro +8 more
doaj +1 more source
The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells [PDF]
, 1997 In a previous publication (Rodriguez, M.L., M. Brignoni, and P.J.I. Salas. 1994. J. Cell Sci. 107: 3145-3151), we described the existence of a terminal web-like structure in nonbrush border cells, which comprises a specifically apical cytokeratin ...
Ana L. Viciana +14 more
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Cells, 2019 Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka +5 more
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