Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse [PDF]
Frontiers in Immunology, 2021 The essential microelement zinc plays immunoregulatory roles via its ability to influence signaling pathways. Zinc deficiency impairs overall immune function and resultantly increases susceptibility to infection.
Bonah Kim +7 more
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CD99-mediated immunological synapse formation potentiates CAR-T cell function [PDF]
Nature CommunicationsDespite the efficacy of chimeric antigen receptor (CAR)-T cells in selected hematological malignancies, further improvement on CAR-T designs is still desirable.
Giri Nam +19 more
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Geometrically repatterned immunological synapses uncover formation mechanisms. [PDF]
PLoS Computational Biology, 2006 The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Marc Thilo Figge, Michael Meyer-Hermann
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Orchestration of Immunological Synapse Assembly by Vesicular Trafficking
Frontiers in Cell and Developmental Biology, 2019 Ligation of the T-cell antigen receptor (TCR) by cognate peptide bound to the Major Histocompatibility Complex on the surface of an antigen-presenting cell (APC) leads to the spatial reorganization of the TCR and accessory receptors to form a specialized
Anna Onnis, Cosima T. Baldari
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Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells
Molecular Therapy, 2018 Chimeric antigen receptor (CAR)-modified T cell therapy has the potential to improve the overall survival of patients with malignancies by enhancing the effectiveness of CAR T cells.
Wei Xiong +2 more
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Multiple actin networks coordinate mechanotransduction at the immunological synapse. [PDF]
J Cell Biol, 2020 T cell activation requires force production at the immunological synapse. Blumenthal and Burkhardt describe how distinct actin structures contribute to this process, addressing canonical immunological models from a mechanobiology perspective.
Blumenthal D, Burkhardt JK.
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Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL [PDF]
eLife, 2014 T cell receptor (TCR) activation leads to a dramatic reorganisation of both membranes and receptors as the immunological synapse forms. Using a genetic model to rapidly inhibit Zap70 catalytic activity we examined synapse formation between cytotoxic T ...
Misty R Jenkins +6 more
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HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse
Viruses, 2010 The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion.
Gaia Vasiliver-Shamis +2 more
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Frontiers in Immunology, 2019 The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule in T cell activation.
Julia M. Laufer +7 more
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Kv1.3 palmitoylation regulates spatial distribution and channel removal from the immunological synapse [PDF]
Cellular and Molecular Life SciencesKv1.3 is the main voltage-gated potassium channel in T cells. At the immunological synapse (IS), it sustains Ca2⁺ signaling and facilitates T cell activation.
María Navarro-Pérez +5 more
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