Results 11 to 20 of about 52,207 (332)

THEIMMUNOLOGICALSYNAPSE

Annual Review of Immunology, 2001
The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Shannon K Bromley, Andrey S Shaw, Michael Dustin   +2 more
exaly   +4 more sources

A Ciliary View of the Immunological Synapse [PDF]

Cells, 2019
The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function.
Chiara Cassioli, Cosima T. Baldari
doaj   +2 more sources

T cell stiffness is enhanced upon formation of immunological synapse [PDF]

eLife, 2021
T cells are activated by target cells via an intimate contact, termed immunological synapse (IS). Cellular mechanical properties, especially stiffness, are essential to regulate cell functions.
Philipp Jung, Xiangda Zhou, Sandra Iden, Markus Bischoff, Bin Qu   +4 more
doaj   +2 more sources

Subdiffraction-resolution fluorescence imaging of immunological synapse formation between NK cells and A. fumigatus by expansion microscopy [PDF]

Communications Biology, 2021
Trinks et al developed a protocol that enables super-resolved visualisation of the interaction between natural killer cells and Aspergillus fumigatus hyphae by expansion microscopy.
Nora Trinks, Sebastian Reinhard, Matthias Drobny, Linda Heilig, Jürgen Löffler, Markus Sauer, Ulrich Terpitz   +6 more
doaj   +2 more sources

Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease [PDF]

Signal Transduction and Targeted Therapy
The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other cells.
Zheng Chao, Qi Mei, Chunguang Yang, Jing Luo, Peikun Liu, Hao Peng, Xiangdong Guo, Zhinan Yin, Le Li, Zhihua Wang   +9 more
doaj   +2 more sources

PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation. [PDF]

J Immunother Cancer
Xiong X, Wang D, Xu L, Chen S, He J, Zhang X, Fang Z, Zhang J, Li W, Zhou P.   +9 more
europepmc   +2 more sources

Comparative anatomy of phagocytic and immunological synapses [PDF]

Frontiers in Immunology, 2016
The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types.
Florence eNiedergang, Vincenzo eDi Bartolo, Andres eAlcover   +2 more
doaj   +4 more sources

The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy. [PDF]

Cell Commun Signal, 2020
Liu D, Badeti S, Dotti G, Jiang JG, Wang H, Dermody J, Soteropoulos P, Streck D, Birge RB, Liu C.   +9 more
europepmc   +3 more sources

Cell polarisation and the immunological synapse

Current Opinion in Cell Biology, 2012
Directed secretion by immune cells requires formation of the immunological synapse at the site of cell-cell contact, concomitant with a dramatic induction of cell polarity. Recent findings provide us with insights into the various steps that are required for these processes: for example, the first identification of a protein at the centrosome that ...
Karen L. Angus, Gillian M. Griffiths
openalex   +3 more sources

Cytotoxic immunological synapses [PDF]

Immunological Reviews, 2010
Summary:  One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Dustin, M, Long, E
openaire   +3 more sources