Results 11 to 20 of about 565,531 (300)
A Ciliary View of the Immunological Synapse [PDF]
Cells, 2019 The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function.
Chiara Cassioli +2 more
exaly +11 more sources
Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both? [PDF]
Frontiers in Immunology, 2023 Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen +6 more
doaj +5 more sources
LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation [PDF]
Cells, 2023 Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high.
Huiping Shi, Bojing Shao, Shao Bojing
exaly +5 more sources
Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +2 more
exaly +5 more sources
Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies [PDF]
Nature Communications, 2023 Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune cells and act within the immunological synapse; an essential cell-to-cell interaction to direct the humoral immune response.
Sayedali Shetab Boushehri +8 more
doaj +3 more sources
The dendritic cell side of the immunological synapse [PDF]
Biomolecular Concepts, 2016 Immune responses are initiated by the interactions between antigen-presenting cells (APCs), such as dendritic cells (DCs), with responder cells, such as T cells, via a tight cellular contact interface called the immunological synapse.
Danielle R J Verboogen +2 more
exaly +3 more sources
Annual Review of Immunology, 2001 The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an ...
Shannon K Bromley +2 more
exaly +5 more sources
CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse [PDF]
Frontiers in Immunology, 2022 T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding ...
Barbara Molon +5 more
doaj +3 more sources
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Science, 1999 The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an
A Grakoui +2 more
exaly +3 more sources
Developing T cells form an immunological synapse for passage through the β-selection checkpoint. [PDF]
J Cell Biol, 2021 The β-selection checkpoint of T cell development tests whether the cell has recombined its genomic DNA to produce a functional T cell receptor β (TCRβ).
Allam AH +3 more
europepmc +3 more sources