Results 11 to 20 of about 241,841 (240)
The dendritic cell side of the immunological synapse [PDF]
Biomolecular Concepts, 2016 Immune responses are initiated by the interactions between antigen-presenting cells (APCs), such as dendritic cells (DCs), with responder cells, such as T cells, via a tight cellular contact interface called the immunological synapse.
Ilse Dingjan +2 more
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CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse [PDF]
Frontiers in Immunology, 2022 T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding ...
Barbara Molon +5 more
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Kv1.3 palmitoylation regulates spatial distribution and channel removal from the immunological synapse [PDF]
Cellular and Molecular Life SciencesKv1.3 is the main voltage-gated potassium channel in T cells. At the immunological synapse (IS), it sustains Ca2⁺ signaling and facilitates T cell activation.
María Navarro-Pérez +5 more
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Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL [PDF]
eLife, 2014 T cell receptor (TCR) activation leads to a dramatic reorganisation of both membranes and receptors as the immunological synapse forms. Using a genetic model to rapidly inhibit Zap70 catalytic activity we examined synapse formation between cytotoxic T ...
Misty R Jenkins +6 more
doaj +2 more sources
Haematologica, 2011 Background T-cell activation relies on the assembly of the immunological synapse, a structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich syndrome protein, an actin cytoskeleton regulator, in linking immunological
Ronan Calvez +5 more
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HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse
Viruses, 2010 The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion.
Catarina E Hioe +2 more
exaly +3 more sources
Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells. [PDF]
PLoS ONE, 2017 Upon recognition of peptide displayed on MHC molecules, Th1 and Th2 cells form distinct immunological synapse structures. Th1 cells have a bull's eye synapse structure with TCR/ MHC-peptide interactions occurring central to a ring of adhesion molecules ...
Jennifer L Gardell, David C Parker
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Connexin-Mediated Signaling at the Immunological Synapse [PDF]
International Journal of Molecular Sciences, 2020 Flavio Salazar +2 more
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Frontiers in Cell and Developmental Biology, 2021 Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of virally infected and malignant cells. The balance between activating and inhibitory signals derived from NK surface receptors govern the NK cell immune response ...
Aviad Ben-Shmuel +3 more
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Frontiers in Immunology, 2022 Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate–adaptive immune response independently.
Jiang-Hui Meng +8 more
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