Results 31 to 40 of about 29,641 (245)
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. [PDF]
PLoS ONE, 2010 RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells,
Hee-Don Chae +4 more
doaj +1 more source
Mechanical Communication at the Immunological Synapse [PDF]
Trends in Cell Biology, 2017 T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force.
Roshni, Basu, Morgan, Huse
openaire +2 more sources
Information transfer at the immunological synapse [PDF]
Current Biology, 2000 Antigen-specific activation of T lymphocytes requires the interaction of their clonally distributed T-cell receptors with plasma membrane ligands composed of foreign peptide antigens bound to major histocompatibility complex molecules. For proliferation and differentiation to ensue, a variety of other adhesive and accessory proteins must also interact ...
Delon, Jérôme, Germain, Ronald N
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The role of the cytoskeleton at the immunological synapse [PDF]
Immunological Reviews, 2013 SummaryIt has been over 30 years since the reorganization of both the microtubule network and a ‘peculiar actin polarization’ was reported at the contact area of cytotoxic T lymphocytes interacting with target cells. Since that time, hundreds of studies have been published in an effort to elucidate the structure and function of the microtubule network ...
Ritter, Alex T +2 more
openaire +2 more sources
T lymphocyte myosin IIA is required for maturation of the immunological synapse
Frontiers in Immunology, 2012 The role of non-muscle myosin IIA (heavy chain encoded by the non-muscle myosin heavy chain 9 gene, Myh9) in immunological synapse formation is controversial.
Sudha eKumari +6 more
doaj +1 more source
Imaging the Human Immunological Synapse [PDF]
Journal of Visualized Experiments, 2019 The purpose of the method is to generate an immunological synapse (IS), an example of cell-to-cell conjugation formed by an antigen-presenting cell (APC) and an effector helper T lymphocyte (Th) cell, and to record the images corresponding to the first stages of the IS formation and the subsequent trafficking events (occurring both in the APC and in ...
Bello-Gamboa, Ana +8 more
openaire +4 more sources
Orchestration of Immunological Synapse Assembly by Vesicular Trafficking
Frontiers in Cell and Developmental Biology, 2019 Ligation of the T-cell antigen receptor (TCR) by cognate peptide bound to the Major Histocompatibility Complex on the surface of an antigen-presenting cell (APC) leads to the spatial reorganization of the TCR and accessory receptors to form a specialized
Anna Onnis, Cosima T. Baldari
doaj +1 more source
The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
Nature Communications, 2022 HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Altered actin centripetal retrograde flow in physically restricted immunological synapses.
PLoS ONE, 2010 Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu +4 more
doaj +1 more source