Results 31 to 40 of about 241,841 (240)

Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation [PDF]

, 2017
Activating T cells reorganize their cortical actin to form a ramified transportation network beneath the immunological synapse.
Felce, JH, Betzig, Eric, Heddleston, JM, Eric Betzig, Liu, Tsung-Li, Chew, TL, Erlenkamper, Christoph, Dominic Waithe, Teng-Leong Chew, Fernandes, Ricardo A., Heddleston, John M, Davis, SJ, Santos, AM, Betzig, E, Clausen, Mathias P, Davis, Simon J, Jorge Bernardino de la Serna, Chang, Veronica T, Marco Fritzsche, Isabela Pedroza-Pacheco, Pedroza-Pacheco, I, Huw Colin-York, Veronica T. Chang, Tsung-li Liu, Clausen, MP, Serna, Jorge Bernardino de la, Ana M. Santos, Galiani, S, Clausen, Mathias P.; id_orcid, Ricardo A. Fernandes, Silvia Galiani, Lagerholm, BC, Pedroza-Pacheco, Isabela, Christoph Erlenkämper, Santos, Ana M, Fritzsche, Marco, James H. Felce, Lagerholm, B Christoffer, Bernardino de la Serna, Jorge, Lagerholm, B. Christoffer, Fernandes, RA, Felce, James H., Christian Eggeling, B. Christoffer Lagerholm, Waithe, D, Eggeling, C, Fernandes, Ricardo A, Colin-York, H, Fritzsche, M, Chew, Teng-Leong, Liu, TL, Mathias P. Clausen, Colin-York, Huw, Chang, VT, Erlenkämper, C, Galiani, Silvia, Felce, James H, Chang, Veronica T., John M. Heddleston, Simon J. Davis, Waithe, Dominic, Davis, Simon J., Eggeling, Christian, de la Serna, JB   +63 more
core   +1 more source

Signaling amplification at the immunological synapse [PDF]

, 2009
The immunological synapse is a dynamic structure, formed between a T cell and one or more antigen-presenting cells, characterized by lipid and protein segregation, signaling compartmentalization, and bidirectional information exchange through soluble and
CONTENTO, RITA LUCIA, MOLON, BARBARA, Barbara Molon, Rita Lucia Contento, R.L. Contento, Antonella Viola, A. Viola, B. Molon, VIOLA, ANTONELLA   +8 more
core   +1 more source

T lymphocyte myosin IIA is required for maturation of the immunological synapse

Frontiers in Immunology, 2012
The role of non-muscle myosin IIA (heavy chain encoded by the non-muscle myosin heavy chain 9 gene, Myh9) in immunological synapse formation is controversial.
Sudha eKumari, Santosha eVardhana, Michael eCammer, Silvia eCurado, Luis eSantos, Michael P Sheetz, Michael L. Dustin   +6 more
doaj   +1 more source

Immunological synapse DC-Tcells

, 2017
Immunological synapse DC ...
Leithner, Alexander F ; https://orcid.org/
core   +1 more source

Orchestration of Immunological Synapse Assembly by Vesicular Trafficking

Frontiers in Cell and Developmental Biology, 2019
Ligation of the T-cell antigen receptor (TCR) by cognate peptide bound to the Major Histocompatibility Complex on the surface of an antigen-presenting cell (APC) leads to the spatial reorganization of the TCR and accessory receptors to form a specialized
Anna Onnis, Cosima T. Baldari
doaj   +1 more source

The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection

Nature Communications, 2022
HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva, Maria Steblyanko, Leticia Kuri-Cervantes, Marcus Buggert, Michael R. Betts, Yuri Sykulev   +5 more
doaj   +1 more source

The immunological synapse: a molecular machine controlling T cell activation.

, 1999
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an
Andrey S. Shaw, Shannon K. Bromley, Cenk Sumen, Mark M. Davis, Paul M. Allen, Arash Grakoui, Michael L. Dustin   +6 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The Immunological Synapse: a Dynamic Platform for Local Signaling [PDF]

, 2010
The immunological synapse (IS) as a concept has evolved from a static view of the junction between T cells and their antigen-presenting cell partners. The entire process of IS formation and extinction is now known to entail a dynamic reorganization of ...
Krummel, Matthew F., Matthew F. Krummel, Michael D. Cahalan, Cahalan, Michael D., Krummel, MF, Cahalan, MD   +5 more
core   +3 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source