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Signaling amplification at the immunological synapse [PDF]
, 2009 The immunological synapse is a dynamic structure, formed between a T cell and one or more antigen-presenting cells, characterized by lipid and protein segregation, signaling compartmentalization, and bidirectional information exchange through soluble and
CONTENTO, RITA LUCIA +8 more
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Signaling and the immunological synapse
, 2010 This chapter deals with T cell activation and immunological synapses. It begins with a brief summary of T cell biology to put a discussion of immune synapses into a broader context because the study of immunological synapses addresses issues pertaining ...
Andrey S. Shaw +3 more
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, 2015 International audienceImmunological synapses are dynamically organised cell–cell interfaces formed between cells of the immune system. Different types of immunological synapses lead to distinct functional outcomes.
Jérôme Bouchet +5 more
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T cell stiffness is enhanced upon formation of immunological synapse [PDF]
eLife, 2021 T cells are activated by target cells via an intimate contact, termed immunological synapse (IS). Cellular mechanical properties, especially stiffness, are essential to regulate cell functions.
Philipp Jung +4 more
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Haematologica, 2011 Background T-cell activation relies on the assembly of the immunological synapse, a structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich syndrome protein, an actin cytoskeleton regulator, in linking immunological
Ronan Calvez +5 more
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Subdiffraction-resolution fluorescence imaging of immunological synapse formation between NK cells and A. fumigatus by expansion microscopy [PDF]
Communications Biology, 2021 Trinks et al developed a protocol that enables super-resolved visualisation of the interaction between natural killer cells and Aspergillus fumigatus hyphae by expansion microscopy.
Nora Trinks +6 more
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Cell polarisation and the immunological synapse
Current Opinion in Cell Biology, 2013 Directed secretion by immune cells requires formation of the immunological synapse at the site of cell-cell contact, concomitant with a dramatic induction of cell polarity. Recent findings provide us with insights into the various steps that are required
Griffiths, Gillian M, Angus, Karen L
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Information transfer at the immunological synapse [PDF]
Current Biology, 2000 Antigen-specific activation of T lymphocytes requires the interaction of their clonally distributed T-cell receptors with plasma membrane ligands composed of foreign peptide antigens bound to major histocompatibility complex molecules.
Germain, Ronald N +3 more
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Imaging the Human Immunological Synapse. [PDF]
Journal of Visualized Experiments, 2019 The purpose of the method is to generate an immunological synapse (IS), an example of cell-to-cell conjugation formed by an antigen-presenting cell (APC) and an effector helper T lymphocyte (Th) cell, and to record the images corresponding to the first ...
Ana Bello-Gamboa +8 more
semanticscholar +5 more sources
The immunological synapse [PDF]
Cancer Immunology Research, 2003 Udgivelsesdato: 2003-nullThe induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells.
Klemmensen, Thomas +2 more
core +7 more sources