Results 1 to 10 of about 73,161 (247)

B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction [PDF]

Frontiers in Immunology, 2022
Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction.
Romina Ulloa, Oreste Corrales, Fernanda Cabrera-Reyes, Jorge Jara-Wilde, Juan José Saez, Christopher Rivas, Jonathan Lagos, Steffen Härtel, Steffen Härtel, Clara Quiroga, Clara Quiroga, María-Isabel Yuseff, Jheimmy Diaz-Muñoz   +12 more
doaj   +4 more sources

Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function [PDF]

Molecular Therapy: Oncology
Targeting immune checkpoint receptors on T cells is a common cancer treatment strategy. Frequently, this is accomplished through antibodies targeting the ligand of inhibitory co-receptors.
Luke Yi Hao, Shalom Lerrer, Matthieu Paiola, Emily K. Moore, Yevgeniya Gartshteyn, Ruijiang Song, Michael Goeckeritz, Matilda J. Black, Shoiab Bukhari, Xizi Hu, Adam Mor   +10 more
doaj   +4 more sources

INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control [PDF]

Communications Biology, 2023
The immune synapse, a highly organized structure formed at the interface between T lymphocytes and antigen-presenting cells (APCs), is essential for T cell activation and the adaptive immune response.
Tzu-Yuan Chiu, Chien-Hui Lo, Yi-Hsuan Lin, Yun-Di Lai, Shan-Shan Lin, Ya-Tian Fang, Wei-Syun Huang, Shen-Yan Huang, Pei-Yuan Tsai, Fu-Hua Yang, Weng Man Chong, Yi-Chieh Wu, Hsing-Chen Tsai, Ya-Wen Liu, Chia-Lin Hsu, Jung-Chi Liao, Won-Jing Wang   +16 more
doaj   +2 more sources

Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response [PDF]

eLife
Endophilin A3-mediated clathrin-independent endocytosis (EndoA3-mediated CIE) contributes to the internalization of immunoglobulin-like proteins, including key immune synapse components.
Shiqiang Xu, Alix Buridant, Thibault Hirsch, Céline Duhamel, Benjamin Ledoux, Massiullah Shafaq-Zadah, Estelle Dransart, Louise Thines, Ludger Johannes, Pierre Van der Bruggen, Pierre Morsomme, Henri-François Renard   +11 more
doaj   +2 more sources

Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes [PDF]

eLife, 2022
Immune synapse formation is a key step for lymphocyte activation. In B lymphocytes, the immune synapse controls the production of high-affinity antibodies, thereby defining the efficiency of humoral immune responses.
Judith Pineau, Léa Pinon, Olivier Mesdjian, Jacques Fattaccioli, Ana-Maria Lennon Duménil, Paolo Pierobon   +5 more
doaj   +2 more sources

NKp46 clusters at the immune synapse and regulates NK cell polarization

Frontiers in Immunology, 2015
Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell-surface expressed inhibitory and activating receptors.
Uzi eHadad, Uzi eHadad, Timothy J Thauland, Olivia M Martinez, Manish J Butte, Angel ePorgador, Sheri M Krams   +6 more
doaj   +3 more sources

Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells

Frontiers in Immunology, 2019
Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Jorge Ibañez-Vega, Felipe Del Valle Batalla, Juan José Saez, Andrea Soza, Andrea Soza, Maria-Isabel Yuseff   +5 more
doaj   +3 more sources

ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse [PDF]

Frontiers in Immunology, 2022
When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing.
Jesse A. Rudd-Schmidt, Romain F. Laine, Romain F. Laine, Romain F. Laine, Tahereh Noori, Tahereh Noori, Amelia J. Brennan, Ilia Voskoboinik, Ilia Voskoboinik   +8 more
doaj   +2 more sources

Actin reorganization at the centrosomal area and the immune synapse regulates polarized secretory traffic of multivesicular bodies in T lymphocytes

Journal of Extracellular Vesicles, 2020
T-cell receptor stimulation induces the convergence of multivesicular bodies towards the microtubule-organizing centre (MTOC) and the polarization of the MTOC to the immune synapse (IS). These events lead to exosome secretion at the IS.
Ana Bello-Gamboa, Marta Velasco, Solange Moreno, Gonzalo Herranz, Roxana Ilie, Silvia Huetos, Sergio Dávila, Alicia Sánchez, Jorge Bernardino De La Serna, Víctor Calvo, Manuel Izquierdo   +10 more
doaj   +2 more sources

Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity

Frontiers in Immunology, 2021
A robust T-cell response is an important component of sustained antitumor immunity. In this respect, the avidity of TCR in the antigen-targeting of tumors is crucial for the quality of the T-cell response.
Hye-Ran Kim, Hye-Ran Kim, Jeong-Su Park, Jeong-Su Park, Yasmin Fatima, Yasmin Fatima, Maiza Kausar, Maiza Kausar, Jin-Hwa Park, Jin-Hwa Park, Chang-Duk Jun, Chang-Duk Jun   +11 more
doaj   +1 more source