Results 1 to 10 of about 1,158,960 (278)

Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes. [PDF]

Elife, 2022
Immune synapse formation is a key step for lymphocyte activation. In B lymphocytes, the immune synapse controls the production of high-affinity antibodies, thereby defining the efficiency of humoral immune responses.
Pineau J, Pinon L, Mesdjian O, Fattaccioli J, Lennon Duménil AM, Pierobon P.   +5 more
europepmc   +3 more sources

Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response. [PDF]

Elife
Endophilin A3-mediated clathrin-independent endocytosis (EndoA3-mediated CIE) contributes to the internalization of immunoglobulin-like proteins, including key immune synapse components.
Xu S, Buridant A, Hirsch T, Duhamel C, Ledoux B, Shafaq-Zadah M, Dransart E, Thines L, Johannes L, Van der Bruggen P, Morsomme P, Renard HF.   +11 more
europepmc   +2 more sources

INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control. [PDF]

Commun Biol, 2023
The immune synapse, a highly organized structure formed at the interface between T lymphocytes and antigen-presenting cells (APCs), is essential for T cell activation and the adaptive immune response.
Chiu TY, Lo CH, Lin YH, Lai YD, Lin SS, Fang YT, Huang WS, Huang SY, Tsai PY, Yang FH, Chong WM, Wu YC, Tsai HC, Liu YW, Hsu CL, Liao JC, Wang WJ.   +16 more
europepmc   +2 more sources

NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization

Frontiers in Immunology, 2015
Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell-surface expressed inhibitory and activating receptors.
Manish Butte, Sheri Krams
exaly   +3 more sources

Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function. [PDF]

Mol Ther Oncol
Targeting immune checkpoint receptors on T cells is a common cancer treatment strategy. Frequently, this is accomplished through antibodies targeting the ligand of inhibitory co-receptors.
Hao LY, Lerrer S, Paiola M, Moore EK, Gartshteyn Y, Song R, Goeckeritz M, Black MJ, Bukhari S, Hu X, Mor A.   +10 more
europepmc   +2 more sources

ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse. [PDF]

Front Immunol, 2022
When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing.
Rudd-Schmidt JA, Laine RF, Noori T, Brennan AJ, Voskoboinik I.   +4 more
europepmc   +2 more sources

Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse

Frontiers in Immunology, 2016
T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility complex molecules (pMHC) present at the surface of antigen ...
Michael Saitakis, Claire Hivroz
exaly   +3 more sources

Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity

Frontiers in Immunology, 2021
A robust T-cell response is an important component of sustained antitumor immunity. In this respect, the avidity of TCR in the antigen-targeting of tumors is crucial for the quality of the T-cell response.
Hye-Ran Kim, Hye-Ran Kim, Jeong-Su Park, Jeong-Su Park, Yasmin Fatima, Yasmin Fatima, Maiza Kausar, Maiza Kausar, Jin-Hwa Park, Jin-Hwa Park, Chang-Duk Jun, Chang-Duk Jun   +11 more
doaj   +1 more source

Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis

Frontiers in Cell and Developmental Biology, 2021
Transgelin-2, a small actin-binding protein, is the only transgelin family member expressed in immune cells. In T and B lymphocytes, transgelin-2 is constitutively expressed, but in antigen-presenting cells, it is significantly upregulated upon ...
Hye-Ran Kim, Hye-Ran Kim, Jeong-Su Park, Jeong-Su Park, Hatice Karabulut, Hatice Karabulut, Fatima Yasmin, Fatima Yasmin, Chang-Duk Jun, Chang-Duk Jun   +9 more
doaj   +1 more source

B cell mechanosensing regulates ER remodeling at the immune synapse [PDF]

Frontiers in Immunology
Maria Isabel Yuseff
exaly   +2 more sources