B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction [PDF]
Frontiers in Immunology, 2022 Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction.
Romina Ulloa +12 more
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Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function [PDF]
Molecular Therapy: OncologyTargeting immune checkpoint receptors on T cells is a common cancer treatment strategy. Frequently, this is accomplished through antibodies targeting the ligand of inhibitory co-receptors.
Luke Yi Hao +10 more
doaj +7 more sources
Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes [PDF]
eLife, 2022 Immune synapse formation is a key step for lymphocyte activation. In B lymphocytes, the immune synapse controls the production of high-affinity antibodies, thereby defining the efficiency of humoral immune responses.
Judith Pineau +5 more
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INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control [PDF]
Communications Biology, 2023 The immune synapse, a highly organized structure formed at the interface between T lymphocytes and antigen-presenting cells (APCs), is essential for T cell activation and the adaptive immune response.
Tzu-Yuan Chiu +16 more
doaj +3 more sources
Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells [PDF]
Frontiers in Immunology, 2019 Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Jorge Ibañez-Vega +5 more
doaj +7 more sources
NKp46 clusters at the immune synapse and regulates NK cell polarization [PDF]
Frontiers in Immunology, 2015 Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell-surface expressed inhibitory and activating receptors.
Uzi eHadad +6 more
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Intrigue at the Immune Synapse [PDF]
Scientific American, 2006 High resolution microscopic images of immune cells contacting other cells have revealed temporary membrane structures similar to the 'synapse' connection nerve cells for communication. The investigations of these immune cell synapses focus on mechanisms that might control the configuration and how the structures modulate communication between cells ...
Davis, Daniel M.
core +6 more sources
Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response [PDF]
eLifeEndophilin A3-mediated clathrin-independent endocytosis (EndoA3-mediated CIE) contributes to the internalization of immunoglobulin-like proteins, including key immune synapse components.
Shiqiang Xu +11 more
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Complement controls the immune synapse and tumors control complement [PDF]
Journal for ImmunoTherapy of Cancer, 2020 The synapses between immune cells and their targets are 150 Å wide. They regulate immune cell responses (IRs) to cognate antigens. Here, I outline a potential mechanism for self-nonself discrimination based on the C3d and iC3b proteolytic fragments of ...
Alan Herbert
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The Immune Synapse: Past, Present, and Future [PDF]
, 2017 Immunological synapses are specialized cell-cell junctions characterized by (1) close apposition of the immune cell membrane with the membrane of another cell driven by adaptive or innate immune recognition, (2) adhesion, (3) stability, and (4) directed secretion.
Dustin, Michael L., Baldari, Cosima
openaire +5 more sources