Results 31 to 40 of about 1,284,834 (277)
Spinophilin and the immune synapse [PDF]
The Journal of Cell Biology, 2008 Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J.
Seed, Brian, Xavier, Ramnik
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Imaging the immune synapse: three-dimensional analysis of the immune synapse
, 2023 ABSTRACT T cell receptor (TCR) stimulation of T lymphocytes by antigen bound to the major histocompatibility complex (MHC) of an antigen-presenting cell (APC), together with the interaction of accessory molecules, induces the formation of the immunological synapse (IS), the convergence of secretion vesicles towards the centrosome, and ...
Javier Ruiz-Navarro +3 more
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, 2022 The simulation was performed for immune synapse levels in blood, bone marrow, lymph node, spleen, and other tissue compartment at a wide range of TCE dose levels (0.001 to 1000 mg/kg/week) in the absence or presence (100 nM) of shed BCMAs in multiple ...
Tomoki Yoneyama (13104824) +4 more
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Concerning immune synapses: a spatiotemporal timeline [PDF]
F1000Research, 2016 The term “immune synapse” was originally coined to highlight the similarities between the synaptic contacts between neurons in the central nervous system and the cognate, antigen-dependent interactions between T cells and antigen-presenting cells. Here, instead of offering a comprehensive molecular catalogue of molecules involved in the establishment ...
Vicente-Manzanares, Miguel +1 more
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Immune synapses: mitochondrial morphology matters [PDF]
The EMBO Journal, 2011 Proper positioning of mitochondria is critical for cellular function. Mitochondria localization close to synapses regulates signalling at neuronal and immune synapses (ISs). Vice versa, synapses influence activity, motility and the fusion/fission balance of close‐by mitochondria.
Christian, Junker, Markus, Hoth
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Receptor Signaling Clusters in the Immune Synapse [PDF]
Annual Review of Biophysics, 2012 Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction ...
Dustin, Michael L, Groves, Jay T
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Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]
, 2002 Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Nigel John Burroughs +3 more
core +1 more source
Systems Imaging of the Immune Synapse [PDF]
, 2017 Three-dimensional live cell imaging of the interaction of T cells with antigen-presenting cells (APCs) visualizes the subcellular distributions of signaling intermediates during T cell activation at thousands of resolved positions within a cell. These information-rich maps of local protein concentrations are a valuable resource in understanding T cell ...
Wuelfing, Christoph +3 more
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Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton [PDF]
Frontiers in Cell and Developmental Biology, 2021 Lymphocytes rearrange their shape, membrane receptors and organelles during cognate contacts with antigen-presenting cells (APCs). Activation of T cells by APCs through pMHC-TCR/CD3 interaction (peptide-major histocompatibility complex-T cell receptor/CD3 complexes) involves different steps that lead to the reorganization of the cytoskeleton and ...
Noa Beatriz Martín-Cófreces +6 more
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Frontiers in Cellular Neuroscience, 2020 Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this
Jaichandar Subramanian +5 more
doaj +1 more source