Results 31 to 40 of about 73,161 (247)
Lytic granule exocytosis at immune synapses: lessons from neuronal synapses
Frontiers in Immunology, 2023 Regulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules. In cytotoxic T lymphocytes (CTLs), the formation of the immunological synapse is required for the delivery ...
Chang, Hsin-Fang +4 more
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Signaling at neuro/immune synapses [PDF]
Journal of Clinical Investigation, 2012 Immunological and neural synapses share properties such as the synaptic cleft, adhesion molecules, stability, and polarity. However, the mismatch in scale has limited the utility of these comparisons. The discovery of phosphatase micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses define a common functional ...
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Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
doaj +1 more source
Molecules, 2016 The ethanolic extract of Lentinula edodes was partially analyzed and then characterized for its efficacy in treating atopic dermatitis. Polyphenols were determined to be the major antioxidant component in the extract (6.12 mg/g), followed by flavonoids ...
Eun-Ju Choi +2 more
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Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse
Nature Communications, 2019 The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti +10 more
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Ecm29-Dependent Proteasome Localization Regulates Cytoskeleton Remodeling at the Immune Synapse
Frontiers in Cell and Developmental Biology, 2021 The formation of an immune synapse (IS) enables B cells to capture membrane-tethered antigens, where cortical actin cytoskeleton remodeling regulates cell spreading and depletion of F-actin at the centrosome promotes the recruitment of lysosomes to ...
Jorge Ibañez-Vega +7 more
doaj +1 more source
Blood, 2008 The immune synapse (IS) forms in response to antigen presentation and T-cell receptor engagement. Following stimulation, components critical for transmitting the activation signal downstream assemble and orchestrate the events required for proper T-cell response.
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Imaging Vesicular Traffic at the Immune Synapse [PDF]
, 2017 Immunological synapse formation is the result of a profound T cell polarization process that involves the coordinated action of the actin and microtubule cytoskeleton, as well as intracellular vesicle traffic. Endosomal vesicle traffic ensures the targeting of the T cell receptor (TCR) and various signaling molecules to the synapse, being necessary for
Bouchet, Jérôme +2 more
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
BMC Biology, 2011 Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo +5 more
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