Results 11 to 20 of about 76,481 (272)
Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse [PDF]
Nature Communications, 2019 The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti +10 more
doaj +4 more sources
Imaging Vesicular Traffic at the Immune Synapse [PDF]
, 2017 Immunological synapse formation is the result of a profound T cell polarization process that involves the coordinated action of the actin and microtubule cytoskeleton, as well as intracellular vesicle traffic. Endosomal vesicle traffic ensures the targeting of the T cell receptor (TCR) and various signaling molecules to the synapse, being necessary for
Bouchet, Jérôme +2 more
openaire +5 more sources
Analysis of TCR/CD3 Recycling at the Immune Synapse [PDF]
, 2017 Engagement of the T cell antigen receptor (TCR) by specific ligand bound to the major histocompatibility complex is the primary event that leads to the assembly of the immune synapse (IS). Central to this process is TCR clustering at the T cell-APC contact, which is achieved with the contribution of an endosomal pool that is delivered to the IS by ...
Patrussi, Laura, Baldari, Cosima
openaire +4 more sources
The cytotoxic T lymphocyte immune synapse at a glance [PDF]
Journal of Cell Science, 2016 ABSTRACT The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to facilitate focal signalling and polarised secretion in immune cells.
Dieckmann, Nele MG +4 more
openaire +5 more sources
ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse [PDF]
Frontiers in Immunology, 2022 When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing.
Jesse A. Rudd-Schmidt +8 more
doaj +2 more sources
Actomyosin-driven force patterning controls endocytosis at the immune synapse [PDF]
Nature Communications, 2019 The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin ...
Anita Kumari +12 more
doaj +2 more sources
Studying the Immune Synapse in HIV-1 Infection [PDF]
, 2017 T cells are the main cellular targets of the human immunodeficiency virus 1 (HIV-1). HIV-1 infection induces pleiotropic effects on the infected T cell that modify the T cell capacity to respond to antigen and facilitates virus replication. HIV-1 infection subverts the formation and function of the immunological synapse altering both actin cytoskeleton
del Río-Iñiguez, Iratxe +2 more
openaire +5 more sources
Intraflagellar transport: a new player at the immune synapse [PDF]
Trends in Immunology, 2011 The assembly and maintenance of primary cilia, which orchestrate signaling pathways centrally implicated in cell proliferation, differentiation and migration, are ensured by multimeric protein particles in a process known as intraflagellar transport (IFT).
Finetti, Francesca +3 more
openaire +6 more sources
Biophysical aspects of T lymphocyte activation at the immune synapse [PDF]
Frontiers in Immunology, 2016 T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility complex molecules (pMHC) present at the surface of antigen ...
Claire eHivroz
doaj +2 more sources
Journal of Extracellular Vesicles, 2020 T-cell receptor stimulation induces the convergence of multivesicular bodies towards the microtubule-organizing centre (MTOC) and the polarization of the MTOC to the immune synapse (IS). These events lead to exosome secretion at the IS.
Ana Bello-Gamboa +10 more
doaj +2 more sources