Results 11 to 20 of about 1,158,960 (278)
Intrigue at the immune synapse
Scientific American, 2006 High resolution microscopic images of immune cells contacting other cells have revealed temporary membrane structures similar to the 'synapse' connection nerve cells for communication.
Davis, Daniel M.
core +14 more sources
Imaging Vesicular Traffic at the Immune Synapse. [PDF]
, 2017 International audienceImmunological synapse formation is the result of a profound T cell polarization process that involves the coordinated action of the actin and microtubule cytoskeleton, as well as intracellular vesicle traffic.
del Río-Iñiguez, Iratxe +5 more
core +4 more sources
Complement controls the immune synapse and tumors control complement
Journal for ImmunoTherapy of Cancer, 2020 The synapses between immune cells and their targets are 150 Å wide. They regulate immune cell responses (IRs) to cognate antigens. Here, I outline a potential mechanism for self-nonself discrimination based on the C3d and iC3b proteolytic fragments of ...
Alan Herbert
doaj +2 more sources
The cytotoxic T lymphocyte immune synapse at a glance. [PDF]
Journal of Cell Science, 2018 The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to facilitate focal signalling ...
Dieckmann, Nele MG +4 more
core +5 more sources
Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse [PDF]
Nature Communications, 2019 The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti +10 more
doaj +3 more sources
Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells [PDF]
Frontiers in Immunology, 2019 Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Jorge Ibañez-Vega +5 more
doaj +2 more sources
Analysis of TCR/CD3 recycling at the immune synapse
, 2017 Engagement of the T cell antigen receptor (TCR) by specific ligand bound to the major histocompatibility complex is the primary event that leads to the assembly of the immune synapse (IS).
Patrussi, Laura +3 more
core +4 more sources
Actomyosin-driven force patterning controls endocytosis at the immune synapse
Nature Communications, 2019 The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin ...
Anita Kumari +12 more
doaj +2 more sources
Concerning immune synapses: a spatiotemporal timeline [version 1; referees: 2 approved] [PDF]
F1000Research, 2016 The term “immune synapse” was originally coined to highlight the similarities between the synaptic contacts between neurons in the central nervous system and the cognate, antigen-dependent interactions between T cells and antigen-presenting cells.
Alvaro Ortega-Carrion +1 more
doaj +3 more sources
The immune synapse: Past, present, and future
, 2017 Immunological synapses are specialized cell-cell junctions characterized by (1) close apposition of the immune cell membrane with the membrane of another cell driven by adaptive or innate immune recognition, (2) adhesion, (3) stability, and (4) directed ...
Dustin, Michael L. +6 more
core +5 more sources