Results 11 to 20 of about 73,161 (247)
Concerning immune synapses: a spatiotemporal timeline [version 1; referees: 2 approved] [PDF]
F1000Research, 2016 The term “immune synapse” was originally coined to highlight the similarities between the synaptic contacts between neurons in the central nervous system and the cognate, antigen-dependent interactions between T cells and antigen-presenting cells.
Alvaro Ortega-Carrion +1 more
doaj +4 more sources
Extracellular vesicles and microvilli in the immune synapse. [PDF]
Front Immunol, 2023 T cell receptor (TCR) binding to cognate antigen on the plasma membrane of an antigen-presenting cell (APC) triggers the immune synapse (IS) formation. The IS constitutes a dedicated contact region between different cells that comprises a signaling platform where several cues evoked by TCR and accessory molecules are integrated, ultimately leading to ...
Ruiz-Navarro J, Calvo V, Izquierdo M.
europepmc +5 more sources
Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis
Frontiers in Cell and Developmental Biology, 2021 Transgelin-2, a small actin-binding protein, is the only transgelin family member expressed in immune cells. In T and B lymphocytes, transgelin-2 is constitutively expressed, but in antigen-presenting cells, it is significantly upregulated upon ...
Hye-Ran Kim +9 more
doaj +1 more source
B cell mechanosensing regulates ER remodeling at the immune synapse [PDF]
Frontiers in ImmunologyMaria-Isabel Yuseff
exaly +2 more sources
Nanoscale restructuring of the immune synapse with an engager enhances NK cell function [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaKhodor S Hazime +2 more
exaly +2 more sources
Spinophilin and the immune synapse [PDF]
The Journal of Cell Biology, 2008 Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J.
Seed, Brian, Xavier, Ramnik
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome ...
Victor Calvo, Manuel Izquierdo
doaj +1 more source
Imaging the immune synapse: three-dimensional analysis of the immune synapse
, 2023 ABSTRACT T cell receptor (TCR) stimulation of T lymphocytes by antigen bound to the major histocompatibility complex (MHC) of an antigen-presenting cell (APC), together with the interaction of accessory molecules, induces the formation of the immunological synapse (IS), the convergence of secretion vesicles towards the centrosome, and ...
Javier Ruiz-Navarro +3 more
openaire +3 more sources
Frontiers in Immunology, 2023 Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen +6 more
doaj +1 more source
A Novel Peptide-MHC Targeted Chimeric Antigen Receptor T Cell Forms a T Cell-like Immune Synapse
Biomedicines, 2021 Chimeric Antigen Receptor (CAR) T cell therapy is a promising form of adoptive cell therapy that re-engineers patient-derived T cells to express a hybrid receptor specific to a tumour-specific antigen of choice.
Stacie Shiqi Wang +6 more
doaj +1 more source