INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control [PDF]
Communications Biology, 2023 The immune synapse, a highly organized structure formed at the interface between T lymphocytes and antigen-presenting cells (APCs), is essential for T cell activation and the adaptive immune response.
Tzu-Yuan Chiu +16 more
doaj +3 more sources
NKp46 clusters at the immune synapse and regulates NK cell polarization [PDF]
Frontiers in Immunology, 2015 Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell-surface expressed inhibitory and activating receptors.
Uzi eHadad +6 more
doaj +4 more sources
Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function [PDF]
Molecular Therapy: OncologyTargeting immune checkpoint receptors on T cells is a common cancer treatment strategy. Frequently, this is accomplished through antibodies targeting the ligand of inhibitory co-receptors.
Luke Yi Hao +10 more
doaj +4 more sources
Intrigue at the immune synapse
Scientific American, 2006 High resolution microscopic images of immune cells contacting other cells have revealed temporary membrane structures similar to the 'synapse' connection nerve cells for communication.
Davis, Daniel M.
core +12 more sources
Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells [PDF]
Frontiers in Immunology, 2019 Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Jorge Ibañez-Vega +5 more
doaj +4 more sources
eLife, 2022 Immune synapse formation is a key step for lymphocyte activation. In B lymphocytes, the immune synapse controls the production of high-affinity antibodies, thereby defining the efficiency of humoral immune responses.
Judith Pineau +5 more
doaj +2 more sources
Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response [PDF]
eLifeEndophilin A3-mediated clathrin-independent endocytosis (EndoA3-mediated CIE) contributes to the internalization of immunoglobulin-like proteins, including key immune synapse components.
Shiqiang Xu +11 more
doaj +2 more sources
Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse [PDF]
Nature Communications, 2019 The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti +10 more
doaj +3 more sources
The cytotoxic T lymphocyte immune synapse at a glance. [PDF]
Journal of Cell Science, 2018 The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to facilitate focal signalling ...
Dieckmann, Nele MG +4 more
core +5 more sources
Actomyosin-driven force patterning controls endocytosis at the immune synapse
Nature Communications, 2019 The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin ...
Anita Kumari +12 more
doaj +2 more sources