Results 41 to 50 of about 1,284,834 (277)

Lytic granule exocytosis at immune synapses: lessons from neuronal synapses

Frontiers in Immunology, 2023
Regulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules. In cytotoxic T lymphocytes (CTLs), the formation of the immunological synapse is required for the delivery ...
Chang, Hsin-Fang, Schirra, Claudia, Pattu, Varsha, Krause, Elmar, Becherer, Ute   +4 more
openaire   +3 more sources

Signaling at neuro/immune synapses [PDF]

Journal of Clinical Investigation, 2012
Immunological and neural synapses share properties such as the synaptic cleft, adhesion molecules, stability, and polarity. However, the mismatch in scale has limited the utility of these comparisons. The discovery of phosphatase micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses define a common functional ...
openaire   +2 more sources

Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells

Cells, 2019
The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer, Céline Hoffmann, Antoun Al Absi, Clément Thomas   +3 more
doaj   +1 more source

Chemical Composition and Inhibitory Effect of Lentinula edodes Ethanolic Extract on Experimentally Induced Atopic Dermatitis in Vitro and in Vivo

Molecules, 2016
The ethanolic extract of Lentinula edodes was partially analyzed and then characterized for its efficacy in treating atopic dermatitis. Polyphenols were determined to be the major antioxidant component in the extract (6.12 mg/g), followed by flavonoids ...
Eun-Ju Choi, Zee-Yong Park, Eun-Kyung Kim   +2 more
doaj   +1 more source

F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse

, 2010
Acknowledgements This work was partly supported by EU-México FONCICYT –C002-2008-1 ALA/127249, SAF-2008-02635, INSINET 01592006 CAM, Red RECAVA RD06/0014-0030 and FIPSE 36658/07 grants. E.V.C.
Gordón-Alonso, Mónica, Vázquez, Jesús, Veiga, Esteban, Shirao, Tomoaki, Yamazaki, Hiroyuki, Román Cabrero, José, Pérez-Martínez, Manuel, Morlino, Giulia, Lamana Domínguez, Amalia, Sánchez-Madrid, Francisco, González-Amaro, Roberto, Barrero-Villar, Marta, Rey, Mercedes, Mittelbrunn, María, Calabia, Carmen, Mercedes Rey, Tomoaki Shirao, José Román Cabrero, Roberto González-Amaro, Mónica Gordón-Alonso, Esteban Veiga, Manuel Pérez-Martínez, Marta Barrero-Villar, Carmen Calabia, Francisco Sánchez-Madrid, Hiroyuki Yamazaki, María Mittelbrunn, Amalia Lamana, Giulia Morlino, Jesús Vázquez   +29 more
core   +1 more source

EnABLing the immune synapse

Blood, 2008
The immune synapse (IS) forms in response to antigen presentation and T-cell receptor engagement. Following stimulation, components critical for transmitting the activation signal downstream assemble and orchestrate the events required for proper T-cell response.
openaire   +3 more sources

Synapse Dysfunctions in Multiple Sclerosis [PDF]

, 2023
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) affecting nearly three million humans worldwide.
Schwarz, Karin, Karin Schwarz, Schmitz, Frank, Frank Schmitz   +3 more
core   +1 more source

Ecm29-Dependent Proteasome Localization Regulates Cytoskeleton Remodeling at the Immune Synapse

Frontiers in Cell and Developmental Biology, 2021
The formation of an immune synapse (IS) enables B cells to capture membrane-tethered antigens, where cortical actin cytoskeleton remodeling regulates cell spreading and depletion of F-actin at the centrosome promotes the recruitment of lysosomes to ...
Jorge Ibañez-Vega, Felipe Del Valle, Juan José Sáez, Fanny Guzman, Jheimmy Diaz, Andrea Soza, Andrea Soza, María Isabel Yuseff   +7 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

BMC Biology, 2011
Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo, Pende Daniela, Cerundolo Vincenzo, Salio Mariolina, Stinchcombe Jane C, Griffiths Gillian M   +5 more
doaj   +1 more source