Results 41 to 50 of about 1,158,960 (278)
Receptor Signaling Clusters in the Immune Synapse [PDF]
Annual Review of Biophysics, 2012 Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction ...
Dustin, Michael L, Groves, Jay T
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Frontiers in Cellular Neuroscience, 2020 Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this
Jaichandar Subramanian +5 more
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Regulation of dendritic spine morphogenesis and synapse formation by copines [PDF]
, 2006 Primary rat hippocampal culture is a well established system to study molecular mechanisms occurring during synapse formation and maturation. By closer analysis of the temporal appearance of presynaptic Bassoon and the postsynaptic proteins SynGAP, PSD ...
Galic, Milos
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Immunological synapse: An emerging target for immune regulation
, 2023 Immunological synapse is termed as a steady interface between immune cells (mainly T-lymphocyte) i.e., derived from thymus along with adhesion molecules and antigen presenting cell (APC).
Nabaneeta Smaraki*1 , Harsh Rajeshbhai Jogi1 , Sonali Sonejita Nayak2, , Ashok Chaudhary2
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Lytic granule exocytosis at immune synapses: lessons from neuronal synapses
Frontiers in Immunology, 2023 Regulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules. In cytotoxic T lymphocytes (CTLs), the formation of the immunological synapse is required for the delivery ...
Chang, Hsin-Fang +4 more
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Casein kinase 2 controls synapse organization and stability [PDF]
, 2013 Synapse remodeling is a local and dynamic process, requiring constant modifications of the neuronal network. Post-translational modifications, such as reversible phosphorylation by kinases and phosphatases, play a crucial role in synapse development and ...
Bulat, Victoria
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Identification and characterization of cell adhesion molecules controlling synapse stability [PDF]
, 2012 Neuronal circuits form the basis of a functional nervous system to process and integrate information and to react to environmental cues. The formation of functional synaptic connections between neurons is essential for the establishment of these circuits.
Enneking, Eva-Maria
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Signaling at neuro/immune synapses [PDF]
Journal of Clinical Investigation, 2012 Immunological and neural synapses share properties such as the synaptic cleft, adhesion molecules, stability, and polarity. However, the mismatch in scale has limited the utility of these comparisons. The discovery of phosphatase micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses define a common functional ...
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Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
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Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells [PDF]
, 2010 It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling.
Mehrabi, M +59 more
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