Results 41 to 50 of about 76,481 (272)
Frontiers in Immunology, 2022 Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate–adaptive immune response independently.
Jiang-Hui Meng +8 more
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Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses [PDF]
, 2011 Immune synapses formed by T and NK cells both show segregation of the integrin ICAM1 from other proteins such as CD2 (T cell) or KIR (NK cell).
Dustin, Michael L. +30 more
core +1 more source
Immune synapses: mitochondrial morphology matters [PDF]
The EMBO Journal, 2011 Proper positioning of mitochondria is critical for cellular function. Mitochondria localization close to synapses regulates signalling at neuronal and immune synapses (ISs). Vice versa, synapses influence activity, motility and the fusion/fission balance of close‐by mitochondria.
Christian, Junker, Markus, Hoth
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menchelab/hci-immune-synapse: v1 [PDF]
, 2019 Content used during manuscript ...
Vulliard Loan
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Receptor Signaling Clusters in the Immune Synapse [PDF]
Annual Review of Biophysics, 2012 Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction ...
Dustin, Michael L, Groves, Jay T
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Systems Imaging of the Immune Synapse [PDF]
, 2017 Three-dimensional live cell imaging of the interaction of T cells with antigen-presenting cells (APCs) visualizes the subcellular distributions of signaling intermediates during T cell activation at thousands of resolved positions within a cell. These information-rich maps of local protein concentrations are a valuable resource in understanding T cell ...
Wuelfing, Christoph +3 more
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Frontiers in Cellular Neuroscience, 2020 Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this
Jaichandar Subramanian +5 more
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Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton. [PDF]
Front Cell Dev Biol, 2021 Lymphocytes rearrange their shape, membrane receptors and organelles during cognate contacts with antigen-presenting cells (APCs). Activation of T cells by APCs through pMHC-TCR/CD3 interaction (peptide-major histocompatibility complex-T cell receptor/CD3 complexes) involves different steps that lead to the reorganization of the cytoskeleton and ...
Martín-Cófreces NB +2 more
europepmc +7 more sources
Lytic granule exocytosis at immune synapses: lessons from neuronal synapses
Frontiers in Immunology, 2023 Regulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules. In cytotoxic T lymphocytes (CTLs), the formation of the immunological synapse is required for the delivery ...
Chang, Hsin-Fang +4 more
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Signaling at neuro/immune synapses [PDF]
Journal of Clinical Investigation, 2012 Immunological and neural synapses share properties such as the synaptic cleft, adhesion molecules, stability, and polarity. However, the mismatch in scale has limited the utility of these comparisons. The discovery of phosphatase micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses define a common functional ...
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