Results 21 to 30 of about 1,158,960 (278)
Intraflagellar transport: a new player at the immune synapse. [PDF]
Trends in Immunology, 2011 The assembly and maintenance of primary cilia, which orchestrate signaling pathways centrally implicated in cell proliferation, differentiation and migration, are ensured by multimeric protein particles in a process known as intraflagellar transport (IFT)
Silvia Rossi Paccani +7 more
core +5 more sources
Studying the Immune Synapse in HIV-1 Infection. [PDF]
, 2017 International audienceT cells are the main cellular targets of the human immunodeficiency virus 1 (HIV-1). HIV-1 infection induces pleiotropic effects on the infected T cell that modify the T cell capacity to respond to antigen and facilitates virus ...
del Río-Iñiguez, Iratxe +5 more
core +4 more sources
Extracellular vesicles and microvilli in the immune synapse. [PDF]
Front Immunol, 2023 T cell receptor (TCR) binding to cognate antigen on the plasma membrane of an antigen-presenting cell (APC) triggers the immune synapse (IS) formation. The IS constitutes a dedicated contact region between different cells that comprises a signaling platform where several cues evoked by TCR and accessory molecules are integrated, ultimately leading to ...
Ruiz-Navarro J, Calvo V, Izquierdo M.
europepmc +5 more sources
Spinophilin and the immune synapse [PDF]
The Journal of Cell Biology, 2008 Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J.
Seed, Brian, Xavier, Ramnik
openaire +2 more sources
Nanoscale restructuring of the immune synapse with an engager enhances NK cell function [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaKhodor Hazime +2 more
exaly +2 more sources
Frontiers in Cell and Developmental Biology, 2021 T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome ...
Victor Calvo, Manuel Izquierdo
doaj +1 more source
Imaging the immune synapse: three-dimensional analysis of the immune synapse
, 2023 ABSTRACT T cell receptor (TCR) stimulation of T lymphocytes by antigen bound to the major histocompatibility complex (MHC) of an antigen-presenting cell (APC), together with the interaction of accessory molecules, induces the formation of the immunological synapse (IS), the convergence of secretion vesicles towards the centrosome, and ...
Javier Ruiz-Navarro +3 more
openaire +3 more sources
Frontiers in Immunology, 2022 Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction.
Romina Ulloa +12 more
doaj +1 more source
Frontiers in Immunology, 2023 Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen +6 more
doaj +1 more source
, 2022 The simulation was performed for immune synapse levels in blood, bone marrow, lymph node, spleen, and other tissue compartment at a wide range of TCE dose levels (0.001 to 1000 mg/kg/week) in the absence or presence (100 nM) of shed BCMAs in multiple ...
Tomoki Yoneyama (13104824) +4 more
core +1 more source