Results 21 to 30 of about 1,284,834 (277)
Analysis of TCR/CD3 recycling at the immune synapse
, 2017 Engagement of the T cell antigen receptor (TCR) by specific ligand bound to the major histocompatibility complex is the primary event that leads to the assembly of the immune synapse (IS).
Patrussi, Laura +3 more
core +4 more sources
ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse [PDF]
Frontiers in Immunology, 2022 When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing.
Jesse A. Rudd-Schmidt +8 more
doaj +2 more sources
Imaging Vesicular Traffic at the Immune Synapse. [PDF]
, 2017 International audienceImmunological synapse formation is the result of a profound T cell polarization process that involves the coordinated action of the actin and microtubule cytoskeleton, as well as intracellular vesicle traffic.
del Río-Iñiguez, Iratxe +5 more
core +4 more sources
Intraflagellar transport: a new player at the immune synapse. [PDF]
Trends in Immunology, 2011 The assembly and maintenance of primary cilia, which orchestrate signaling pathways centrally implicated in cell proliferation, differentiation and migration, are ensured by multimeric protein particles in a process known as intraflagellar transport (IFT)
Silvia Rossi Paccani +7 more
core +5 more sources
Dysfunctional Immune Synapses in T Cell Immunodeficiencies
, 2021 Adaptive immune responses take place in the T cell area of secondary lymphoid organs, where, on encounter of antigen-presenting cells (APCs) bearing specific MHC-associated antigen, T lymphocytes assemble a highly organized intercellular junction ...
Patrussi, L. +7 more
core +4 more sources
Journal of Extracellular Vesicles, 2020 T-cell receptor stimulation induces the convergence of multivesicular bodies towards the microtubule-organizing centre (MTOC) and the polarization of the MTOC to the immune synapse (IS). These events lead to exosome secretion at the IS.
Ana Bello-Gamboa +10 more
doaj +2 more sources
Biophysical aspects of T lymphocyte activation at the immune synapse [PDF]
Frontiers in Immunology, 2016 T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility complex molecules (pMHC) present at the surface of antigen ...
Claire eHivroz
doaj +2 more sources
Extracellular vesicles and microvilli in the immune synapse. [PDF]
Front Immunol, 2023 T cell receptor (TCR) binding to cognate antigen on the plasma membrane of an antigen-presenting cell (APC) triggers the immune synapse (IS) formation. The IS constitutes a dedicated contact region between different cells that comprises a signaling platform where several cues evoked by TCR and accessory molecules are integrated, ultimately leading to ...
Ruiz-Navarro J, Calvo V, Izquierdo M.
europepmc +5 more sources
Frontiers in Immunology, 2021 A robust T-cell response is an important component of sustained antitumor immunity. In this respect, the avidity of TCR in the antigen-targeting of tumors is crucial for the quality of the T-cell response.
Hye-Ran Kim +11 more
doaj +1 more source
Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis
Frontiers in Cell and Developmental Biology, 2021 Transgelin-2, a small actin-binding protein, is the only transgelin family member expressed in immune cells. In T and B lymphocytes, transgelin-2 is constitutively expressed, but in antigen-presenting cells, it is significantly upregulated upon ...
Hye-Ran Kim +9 more
doaj +1 more source