Results 21 to 30 of about 76,481 (272)
Concerning immune synapses: a spatiotemporal timeline [version 1; referees: 2 approved] [PDF]
F1000Research, 2016 The term “immune synapse” was originally coined to highlight the similarities between the synaptic contacts between neurons in the central nervous system and the cognate, antigen-dependent interactions between T cells and antigen-presenting cells.
Alvaro Ortega-Carrion +1 more
doaj +3 more sources
Dysfunctional Immune Synapses in T Cell Immunodeficiencies [PDF]
, 2021 Adaptive immune responses take place in the T cell area of secondary lymphoid organs, where, on encounter of antigen-presenting cells (APCs) bearing specific MHC-associated antigen, T lymphocytes assemble a highly organized intercellular junction, referred to as the immune synapse, on which T cell activation, proliferation, and differentiation ...
Capitani, N. +3 more
openaire +4 more sources
Extracellular vesicles and microvilli in the immune synapse. [PDF]
Front Immunol, 2023 T cell receptor (TCR) binding to cognate antigen on the plasma membrane of an antigen-presenting cell (APC) triggers the immune synapse (IS) formation. The IS constitutes a dedicated contact region between different cells that comprises a signaling platform where several cues evoked by TCR and accessory molecules are integrated, ultimately leading to ...
Ruiz-Navarro J, Calvo V, Izquierdo M.
europepmc +5 more sources
Platform TCE model-based simulation of dose-to-immune-synapse-level relationship for PF-06863135 (an IgG format, 150 kDa) and AMG420 (a BiTE format, 54 kDa) in multiple myeloma patients. [PDF]
, 2022 The simulation was performed for immune synapse levels in blood, bone marrow, lymph node, spleen, and other tissue compartment at a wide range of TCE dose levels (0.001 to 1000 mg/kg/week) in the absence or presence (100 nM) of shed BCMAs in multiple ...
Tomoki Yoneyama (13104824) +4 more
core +1 more source
Frontiers in Immunology, 2021 A robust T-cell response is an important component of sustained antitumor immunity. In this respect, the avidity of TCR in the antigen-targeting of tumors is crucial for the quality of the T-cell response.
Hye-Ran Kim +11 more
doaj +1 more source
Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis
Frontiers in Cell and Developmental Biology, 2021 Transgelin-2, a small actin-binding protein, is the only transgelin family member expressed in immune cells. In T and B lymphocytes, transgelin-2 is constitutively expressed, but in antigen-presenting cells, it is significantly upregulated upon ...
Hye-Ran Kim +9 more
doaj +1 more source
B cell mechanosensing regulates ER remodeling at the immune synapse [PDF]
Frontiers in ImmunologyMaria Isabel Yuseff
exaly +2 more sources
Nanoscale restructuring of the immune synapse with an engager enhances NK cell function [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaKhodor Hazime +2 more
exaly +2 more sources
Spinophilin and the immune synapse [PDF]
The Journal of Cell Biology, 2008 Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J.
Seed, Brian, Xavier, Ramnik
openaire +2 more sources