Results 51 to 60 of about 76,481 (272)

Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells [PDF]

, 2010
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling.
Mehrabi, M, Brzostek, Joanna, Nigel J Burroughs, Stephane Oddos, Nigel J. Burroughs, Harrison, A, Van der Merwe, Philip Anton, Eissmann, P, Miloserdov, V, Maryam Mehrabi, Daniel M Davis, Koehler, Karsten, Daniel M. Davis, Gould, K, Alice Harrison, Köhler, K, Harrison Alice, Eissmann, Philipp, Oddos, S, Shiqiu Xiong, Davis, Daniel M., Köhler Karsten, Xiong, S, Burroughs, NJ, Köhler, Karsten, Cordoba, Shaun-Paul, Philipp Eissmann, Oddos, Stephane, Xiong, Shiqiu, Miloserdov, Vladimir, Gould Keith, Philip Anton van der Merwe, Davis, DM, Mehrabi, Maryam, Xiong Shiqiu, Cordoba, SP, Burroughs, Nigel J, Davis Daniel M., Miloserdov Vladimir, van der Merwe, PA, Brzostek, J, van der Merwe Philip Anton, Mehrabi Maryam, Karsten Köhler, Burroughs Nigel J., Harrison, Alice, Joanna Brzostek, Cordoba, Shaun Paul, Oddos Stephane, van der Merwe, Philip, Shaun-Paul Cordoba, Burroughs, Nigel J., Cordoba Shaun-Paul, Davis, Daniel M, Burroughs, Nigel John, Gould, Keith, Keith Gould, Vladimir Miloserdov, Eissmann Philipp, Brzostek Joanna   +59 more
core   +1 more source

Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells

Cells, 2019
The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer, Céline Hoffmann, Antoun Al Absi, Clément Thomas   +3 more
doaj   +1 more source

Chemical Composition and Inhibitory Effect of Lentinula edodes Ethanolic Extract on Experimentally Induced Atopic Dermatitis in Vitro and in Vivo

Molecules, 2016
The ethanolic extract of Lentinula edodes was partially analyzed and then characterized for its efficacy in treating atopic dermatitis. Polyphenols were determined to be the major antioxidant component in the extract (6.12 mg/g), followed by flavonoids ...
Eun-Ju Choi, Zee-Yong Park, Eun-Kyung Kim   +2 more
doaj   +1 more source

EnABLing the immune synapse

Blood, 2008
The immune synapse (IS) forms in response to antigen presentation and T-cell receptor engagement. Following stimulation, components critical for transmitting the activation signal downstream assemble and orchestrate the events required for proper T-cell response.
openaire   +3 more sources

Ecm29-Dependent Proteasome Localization Regulates Cytoskeleton Remodeling at the Immune Synapse

Frontiers in Cell and Developmental Biology, 2021
The formation of an immune synapse (IS) enables B cells to capture membrane-tethered antigens, where cortical actin cytoskeleton remodeling regulates cell spreading and depletion of F-actin at the centrosome promotes the recruitment of lysosomes to ...
Jorge Ibañez-Vega, Felipe Del Valle, Juan José Sáez, Fanny Guzman, Jheimmy Diaz, Andrea Soza, Andrea Soza, María Isabel Yuseff   +7 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

BMC Biology, 2011
Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo, Pende Daniela, Cerundolo Vincenzo, Salio Mariolina, Stinchcombe Jane C, Griffiths Gillian M   +5 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism

Cells, 2021
LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments.
Juan José Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andrés Ernesto Zucchetti   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source